2. Membrane Transporter/Ion Channel Anti-infection Metabolic Enzyme/Protease
  3. OAT HIV HIV Integrase
  4. Cabotegravir sodium

Cabotegravir sodium  (Synonyms: GSK-1265744 sodium; S/GSK1265744 sodium)

Cat. No.: HY-15592A Purity: 99.87%
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Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS.

For research use only. We do not sell to patients.

CAS No. : 1051375-13-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Cabotegravir sodium:

Cabotegravir sodium Related Antibodies

Top Publications Citing Use of Products

    Cabotegravir sodium purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2025 Jul 15:jiaf362.  [Abstract]

    Cabotegravir (CAB, 5.0mg/kg, administered via oral gavage daily). The viability rate is depicted.

    Cabotegravir sodium purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2025 Jul 15:jiaf362.  [Abstract]

    Cabotegravir (CAB, 5.0mg/kg, administered via oral gavage daily). Dam litter size and percent increase in maternal weight normalized to litter size.

    Cabotegravir sodium purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2025 Jul 15:jiaf362.  [Abstract]

    Cabotegravir (CAB, 5.0 mg/kg, gavage once daily). Representative SSEA3 + flow plot of DTG dose response in CA1S hESCs compared with the fluorescence minus 1 (FMO) and 0.1% DMSO controls; vertical line denotes SSEA-3 positivity.

    Cabotegravir sodium purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2022 Nov 28;226(11):1992-2001.  [Abstract]

    Exposure to bictegravir (BIC)-, Cabotegravir (CAB, 5.0 mg/kg, gavage once daily)-, and dolutegravir (DTG)-containing combination antiretroviral therapy (cART) results in loss of pluripotency markers. SSEA-3+ and TRA-1-60+ expression normalized to corresponding 0.1% dimethyl sulfoxide (DMSO) vehicle controls (dashed lines), after exposure to no treatment (culture media without 0.1% DMSO, Ø), or 1× Cmax (unless indicated) cART regimens, in CA1S (left, n = 5) and H9 (right, n = 6, with an additional n = 4 at 0.5× Cmax) cells, respectively. Data collected via flow cytometry.

    Cabotegravir sodium purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2022 Nov 28;226(11):1992-2001.  [Abstract]

    Bictegravir (BIC), Cabotegravir (CAB, 5.0 mg/kg, gavage once daily), and dolutegravir (DTG) human embryonic stem cell (hESC) toxicity and differentiation occur in a dose-dependent manner. Live cell count, viability, apoptosis normalized to 0.1% dimethyl sulfoxide (DMSO) control in CA1S (left, n = 3) and H9 (right, n = 6) hESCs treated with 5 (4 in H9) different integrase strand transfer inhibitors at various doses for 3.5 days.

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    • Purity & Documentation

    • References

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    Description

    Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS[1][2].

    IC50 & Target

    IC50: 2.5 nM (HIVADA)[1]
    IC50: 0.41 μM (OAT3), 0.81 μM (OAT1)[2]
    In Vitro

    Cabotegravir (GSK-1265744) inhibits the HIV-1 integrase catalyzed strand transfer reaction with an IC50 of 3.0 nM in vitro. The antiviral EC50 against HIV-1 Ba-L is 0.22 nM and that against NL432 is 0.34 nM in PBMCs, 0.57 nM using CellTiter-Glo and 1.3 nM using MTT in MT-4, and 0.5 nM in the PHIV assay, which uses a pseudotyped self-inactivating virus[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cabotegravir sodium Related Antibodies

    Cell Viability Assay[3]

    Cell Line: MT-4 cells
    Concentration: 0-32 nM
    Incubation Time: 4 or 5 days
    Result: Showed antiviral activity with an EC50 of 1.3 nM.
    In Vivo

    The half-life of Cabotegravir is up to 54 days in mice[1].
    Cabotegravir (25 or 50 mg/kg; i.v.; single dose or twice) protects Macaques against intravenous challenge with SIVmac251[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    427.33

    Formula

    C19H16F2N3NaO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    FC1=C(CNC(C2=CN3C(C(N([C@@H](C)CO4)[C@@]4([H])C3)=O)=C(O[Na])C2=O)=O)C=CC(F)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 6.25 mg/mL (14.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3401 mL 11.7006 mL 23.4011 mL
    5 mM 0.4680 mL 2.3401 mL 4.6802 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.87%

    SDS (398 KB)

    COA (253 KB) HNMR (143 KB) LCMS (93 KB) Others (338 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3401 mL 11.7006 mL 23.4011 mL 58.5028 mL
    5 mM 0.4680 mL 2.3401 mL 4.6802 mL 11.7006 mL
    10 mM 0.2340 mL 1.1701 mL 2.3401 mL 5.8503 mL
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    Cabotegravir sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cabotegravir1051375-13-3GSK-1265744S/GSK1265744GSK1265744GSK 1265744OATHIVHIV IntegraseOrganic anion transporterHuman immunodeficiency virusantiretroviralAIDSUGT1A1Inhibitorinhibitorinhibit

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