1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Integrase

Cabotegravir (Synonyms: GSK-1265744; S/GSK1265744)

Cat. No.: HY-15592 Purity: 99.85%
Handling Instructions

Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM).

For research use only. We do not sell to patients.

Cabotegravir Chemical Structure

Cabotegravir Chemical Structure

CAS No. : 1051375-10-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 984 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM). IC50 value: 0.81 μM (OAT1), 0.41 μM (OAT3) [1] Target: OAT1, OAT3 Cabotegravir is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection.[2] Cabotegravir is an HIV-1 integrase inhibitor under development as a tablet for both oral lead-in therapy and long-acting (LA) injectable for intramuscular dosing.[3]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 12.67 mg/mL (31.26 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4670 mL 12.3350 mL 24.6700 mL
5 mM 0.4934 mL 2.4670 mL 4.9340 mL
10 mM 0.2467 mL 1.2335 mL 2.4670 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

405.35

Formula

C₁₉H₁₇F₂N₃O₅

CAS No.

1051375-10-0

SMILES

FC1=C(CNC(C2=CN3C(C(N([[email protected]@H](C)CO4)[[email protected]@]4([H])C3)=O)=C(O)C2=O)=O)C=CC(F)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cabotegravir
Cat. No.:
HY-15592
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Cabotegravir

Cat. No.: HY-15592