1. Anti-infection
    Metabolic Enzyme/Protease
  2. HIV
    HIV Integrase
  3. Cabotegravir

Cabotegravir (Synonyms: GSK-1265744; S/GSK1265744)

Cat. No.: HY-15592 Purity: 98.04%
Handling Instructions

Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection.

For research use only. We do not sell to patients.

Cabotegravir Chemical Structure

Cabotegravir Chemical Structure

CAS No. : 1051375-10-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 105 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM). IC50 value: 0.81 μM (OAT1), 0.41 μM (OAT3) [1] Target: OAT1, OAT3 Cabotegravir is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection.[2] Cabotegravir is an HIV-1 integrase inhibitor under development as a tablet for both oral lead-in therapy and long-acting (LA) injectable for intramuscular dosing.[3]

Clinical Trial
Molecular Weight

405.35

Formula

C₁₉H₁₇F₂N₃O₅

CAS No.
SMILES

FC1=C(CNC(C2=CN3C(C(N([[email protected]@H](C)CO4)[[email protected]@]4([H])C3)=O)=C(O)C2=O)=O)C=CC(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (41.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4670 mL 12.3350 mL 24.6700 mL
5 mM 0.4934 mL 2.4670 mL 4.9340 mL
10 mM 0.2467 mL 1.2335 mL 2.4670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

CabotegravirGSK-1265744 S/GSK1265744GSK1265744GSK 1265744HIVHIV IntegraseHuman immunodeficiency virusInhibitorinhibitorinhibit

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Product Name:
Cabotegravir
Cat. No.:
HY-15592
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