1. Anti-infection
  2. HIV
    Reverse Transcriptase

GS-7340 (Synonyms: Tenofovir alafenamide)

Cat. No.: HY-15232 Purity: 99.81%
Data Sheet SDS Handling Instructions

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

For research use only. We do not sell to patients.
GS-7340 Chemical Structure

GS-7340 Chemical Structure

CAS No. : 379270-37-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $110 In-stock
50 mg $330 In-stock
100 mg $500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of GS-7340:

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  • Purity & Documentation

  • References

Description

GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. IC50 value: Target: NRTI; HIV reverse transcriptase inhibitor GS-7340 reduces first-pass clearance to be an effective oral prodrug, its permeability and stability were characterized in vitro and detailed pharmacokinetic studies were completed in dogs. GS-7340 showed concentration-dependent permeability through monolayers of caco-2 cells and dose-dependent oral bioavailability in dogs, increasing from 1.7% at 2 mg/kg to 24.7% at 20 mg/kg, suggesting saturable intestinal efflux transport [1]. Significant reductions in plasma HIV-1 RNA from baseline to day 11 were observed for all TAF dose groups compared with placebo (P < 0.01), with a median decrease of 1.08-1.73 log10 copies per milliliter, including a dose-response relationship for viral load decrease up to 25 mg [2].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0988 mL 10.4938 mL 20.9877 mL
5 mM 0.4198 mL 2.0988 mL 4.1975 mL
10 mM 0.2099 mL 1.0494 mL 2.0988 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

476.47

Formula

C₂₁H₂₉N₆O₅P

CAS No.

379270-37-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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GS-7340
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HY-15232
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