2. Anti-infection
  3. HIV Reverse Transcriptase
  4. Tenofovir alafenamide

Tenofovir alafenamide  (Synonyms: GS-7340)

Cat. No.: HY-15232 Purity: 99.02%
COA Handling Instructions

Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

For research use only. We do not sell to patients.

Tenofovir alafenamide Chemical Structure

Tenofovir alafenamide Chemical Structure

CAS No. : 379270-37-8

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 77 In-stock
50 mg USD 154 In-stock
100 mg USD 209 In-stock
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500 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Tenofovir alafenamide:

Tenofovir alafenamide Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

IC50 & Target

HIV-1

 

HIV-2

 

In Vitro

Tenofovir alafenamide (GS-7340) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tenofovir alafenamide Related Antibodies
In Vivo

Tenofovir alafenamide (GS-7340) hemifumarate is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

476.47

Appearance

Solid

Formula

C21H29N6O5P
CAS No.
SMILES

NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (65.06 mM)

H2O : 6.67 mg/mL (14.00 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0988 mL 10.4938 mL 20.9877 mL
5 mM 0.4198 mL 2.0988 mL 4.1975 mL
10 mM 0.2099 mL 1.0494 mL 2.0988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 40 mg/mL (83.95 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.37 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.37 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.92%

COA (252 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References
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Tenofovir alafenamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tenofovir alafenamide379270-37-8GS-7340GS7340GS 7340HIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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