2. Anti-infection
  3. HIV Reverse Transcriptase
  4. Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate  (Synonyms: GS-7340 hemifumarate)

Cat. No.: HY-15232B Purity: 99.45%
COA Handling Instructions

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

For research use only. We do not sell to patients.

Tenofovir alafenamide hemifumarate Chemical Structure

Tenofovir alafenamide hemifumarate Chemical Structure

CAS No. : 1392275-56-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 59 In-stock
Solid
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10 mg USD 70 In-stock
50 mg USD 140 In-stock
100 mg USD 190 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Tenofovir alafenamide hemifumarate:

Tenofovir alafenamide hemifumarate Related Antibodies

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Description

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

IC50 & Target

HIV-1

 

HIV-2

 

In Vitro

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tenofovir alafenamide hemifumarate Related Antibodies
In Vivo

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

534.50

Appearance

Solid

Formula

C21H29N6O5P.1/2 C4H4O4
CAS No.
SMILES

O=C(O)/C=C/C(O)=O.NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O.[0.5]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (93.55 mM; Need ultrasonic)

H2O : 20 mg/mL (37.42 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8709 mL 9.3545 mL 18.7091 mL
5 mM 0.3742 mL 1.8709 mL 3.7418 mL
10 mM 0.1871 mL 0.9355 mL 1.8709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 4.55 mg/mL (8.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (4.68 mM); Clear solution; Need warming

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.70%

COA (259 KB) HNMR (196 KB) RP-HPLC (201 KB)

Handling Instructions (2659 KB)
References
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Tenofovir alafenamide hemifumarate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tenofovir alafenamide hemifumarate1392275-56-7GS-7340 hemifumarateHIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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