1. Oligonucleotides
  2. Cap Analogs

Cap Analogs

The “cap” structure (m7G[5']ppp[5']N, where N is any nucleotide) is present at the 5-end of eukaryotic mRNA molecules synthesized by RNA polymerase II. It typically consists of a 7-methylguanosine moiety attached via a 5-5 triphosphate bridge to the 5-terminal nucleoside of the RNA strand. The distinct cap structure plays a vital role in providing resistance to 5′‐exonuclease that helps to protect the mRNA from speedy degradation by 5′‐exonuclease activity. It has participated in numerous aspects of mRNA metabolism such as intracellular transport, splicing, subcellular localization, initiation of RNA, translation, and mRNA turnover. The use of the synthetic dinucleotide analog m7G[5']ppp[5']G has been the most common method for in vitro synthesis of 5-capped mRNAs. The presence of cap structure confers mRNA stability and enables efficient translation.

Cap Analogs (5):

Cat. No. Product Name CAS No. Purity Chemical Structure