3'-O-Me-m7G(5')ppp(5')A solution (100 mM)
Based on 1 Customer Validation
3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100 mM), anti-reverse cap analog, has a special RNA cap structure. 3'-O-Me-m7G(5')ppp(5')A solution (100 mM) improves mRNA translation efficiency and stability, reduces translational inhibition by proteins such as IFIT1, and enables stronger and longer-lasting expression of the target protein. The RNA cap structure is a common feature of mRNAs in some RNA viruses and eukaryotes, and it serves as a signal for translation initiation.
For research use only. We do not sell to patients.
- Purity: 99.38%
- Formula: C22H37N12O17P3
- Molecular Weight:834.52
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Storage:
Solution, -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
ARCA?capped mRNA purified by HPLC has minimal impact on the metabolic activity of mesenchymal stem cells and does not trigger a significant innate immune response, making it the preferred cap structure for in vitro engineering of MSCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Molecular Weight 834.52
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Formula C22H37N12O17P3
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Color Colorless to light yellow
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SMILES
O[C@@H]1[C@H](OC)[C@@H](COP(OP(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)([O-])=O)([O-])=O)([O-])=O)O[C@H]1N5C(N=C(N)NC6=O)=C6[N+](C)=C5.[NH4+].[NH4+]
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Synonyms
ARCA cap solution (100 mM)
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Shipping
Shipping with dry ice.
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Storage
Solution, -20°C, 1 year
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hadas Y, et al. Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy. Mol Ther Methods Clin Dev. 2019 Jul 30;14:300-305. [Content Brief]
[2]. Andrzejewska A, et al. Mesenchymal stem cell engineering by ARCA analog-capped mRNA. Mol Ther Nucleic Acids. 2023;33:454-468. Published 2023 Jul 17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3'-O-Me-m7G(5')ppp(5')A solution (100 mM) Related Classifications
HY-153108 Related Classifications
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