Pseudouridine 5'-triphosphate trisodium solution (100 mM)  (Synonyms: Pseudo-UTP trisodium solution (100 mM))

Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection^[1][2].

Pseudouridine 5'-triphosphate (1 mM) trisodium solution (100 mM) supports full transcription elongation of vaccinia virus early genes in vitro but dramatically inhibits VTF-dependent transcription termination, reducing termination efficiency to 25% in the bead-bound G21(TER29)A78 template system^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

550.09

C₉H₁₂N₂Na₃O₁₅P₃

Liquid

Colorless to light yellow

O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Shanmugasundaram M, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016;35(7):356-362.  [Content Brief]

  [2]. Mohamed MR, et al. Effect of UTP sugar and base modifications on vaccinia virus early gene transcription. Virology. 2006;349(2):359-370.