Pseudouridine 5'-triphosphate trisodium solution (100 mM)
Based on 1 publication(s) in Google Scholar
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection.
For research use only. We do not sell to patients.
- Purity: 98.0%
- Formula: C9H12N2Na3O15P3
- Molecular Weight:550.09
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pseudouridine 5'-triphosphate trisodium solution (100 mM)
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Biological Activity
Pseudouridine 5'-triphosphate (1 mM) trisodium solution (100 mM) supports full transcription elongation of vaccinia virus early genes in vitro but dramatically inhibits VTF-dependent transcription termination, reducing termination efficiency to 25% in the bead-bound G21(TER29)A78 template system[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Molecular Weight 550.09
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Formula C9H12N2Na3O15P3
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Color Colorless to light yellow
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SMILES
O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O
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Synonyms
Pseudo-UTP trisodium solution (100 mM)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. [Abstract]2023 May 23;42(6):112550. PMID: 37224018
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shanmugasundaram M, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016;35(7):356-362. [Content Brief]
[2]. Mohamed MR, et al. Effect of UTP sugar and base modifications on vaccinia virus early gene transcription. Virology. 2006;349(2):359-370. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pseudouridine 5'-triphosphate trisodium solution (100 mM) Related Classifications
HY-141567A Related Classifications
Powered by Bioz
- Pseudouridine 5'-triphosphate trisodium solution (100 mM)
- Pseudo-UTP trisodium solution (100 mM)
- DNA/RNA Synthesis
- vaccinia virus early gene transcription
- mRNA
- signal-dependent transcription termination
- transcription elongation
- vaccinia virus infection
- Pseudouridine 5'-triphosphate
- uracil base-modified UTP derivative
- modified ribonucleoside triphosphate
- innate immune responses
- mammalian cells
- Inhibitor
- inhibitor
- inhibit