1. Recombinant Proteins
  2. Immune Checkpoint Proteins CAR-T related Proteins
  3. Inhibitory Checkpoint Molecules
  4. B7-H3

B7 homolog 3 (B7-H3, also named CD276) is a type I transmembrane protein that belongs to the B7-CD28 family. It is conserved in mice and humans, with ~88% amino acid identity. B7-H3 is widely expressed in both lymphoid and nonlymphoid organs at the transcriptional level, but the expression of B7-H3 protein is more restricted to cell types such as activated dendritic cells (DCs), monocytes, T cells, B cells, and NK cells. B7-H3 acts as a co-stimulatory/co-inhibitory immunoregulatory molecule in the immune system. As a co-stimulatory molecule, B7-H3 stimulates the T cell response and IFN-γ production. Several current studies reported that B7-H3 potently inhibits T cell proliferation and IFN-γ, IL-2, IL-10, and IL-13 production. The receptor for B7-H3 has not yet been identified and it may explain the intricate immunomodulatory activity of B7-H3. More importantly, B7-H3 plays an important role in tumor immune evasion and metastasis. It is commonly overexpressed in multiple malignancies including melanoma, NSCLC, prostate, pancreatic, ovarian, and CRC.

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