MASP-2
MASP-2 (mannose-binding lectin-associated serine protease 2) is the key enzymatic effector of the lectin complement pathway, encoded by the MASP2 gene. When mannose-binding lectin or ficolins engage microbial surfaces, MASP-2, activated through autoactivation and transactivation by MASP-1, cleaves C4 and C2 to assemble the C3 convertase C4b2a. Unlike MASP-1, MASP-2 is largely dedicated to complement and circulates bound to its pattern-recognition partners in a proenzyme state. Hereditary MASP2 deficiency, while rare, causes a profound lectin-pathway defect that manifests as recurrent infections, particularly in early childhood; polymorphisms in MASP2 have also been linked to various inflammatory and thrombotic disorders, prompting development of targeted MASP-2 inhibitors.
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MASP-2 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
