2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. B7-H4

B7-H4

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B7-H4 (also known as B7-S1, B7x and VCTN1), a member of the CD28/B7 family, is a transmembrane protein and a T-cell immune co-inhibitory molecule. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine secretion, and cell cycle of T cells. B7-H4 is limited expressed in normal peripheral tissues, whereas it is abnormally expressed in inflammation, autoimmune diseases and tumors, such as breast carcinomas. The amino acid sequence of human B7-H4 is highly conserved with approximately 87% amino acid identity to mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78073
    B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi)

    B7H4; B7-H4; B7S1; B7h.5; B7x; FLJ22418; VTCN1; PRO1291

    		Human HEK293
    The B7-H4 protein acts as a negative regulator, inhibiting T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived B7-H4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi) is 230 a.a., with molecular weight of 60-70 kDa.
  • HY-P7640
    B7-H4 Protein, Human (HEK293, Fc)

    rHuB7-H4, C-Fc; B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1

    		Human HEK293
    B7-H4 Protein, Human (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.
  • HY-P74394
    B7-H4 Protein, Mouse (HEK293, His)

    V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

    		Mouse HEK293
    The B7-H4 protein acts as a negative regulator and inhibits T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. Significant significance can be observed when expressed on tumor macrophages, cooperating with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Mouse (HEK293, His) is 228 a.a., with molecular weight of ~26.6 kDa.
  • HY-P7641
    B7-H4 Protein, Mouse (HEK293, Fc)

    rMuB7-H4, C-Fc; V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; Protein B7S1; B7-H4;

    		Mouse HEK293
    B7-H4 Protein, Mouse (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.
  • HY-P7642
    B7-H4 Protein, Rhesus macaque (HEK293, His)

    rRhB7-H4, His; B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1

    		Rhesus Macaque HEK293
    B7-H4 Protein, Rhesus macaque (HEK293, His) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.
  • HY-P72341
    B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    B7S1; B7x; Vtcn1; B7h.5; B7S1VCTN1; B7XPRO1291; FLJ22418; Protein B7S1; T cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1

    		Human HEK293
    The B7-H4 protein acts as a negative regulator, inhibiting T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived B7-H4 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 230 a.a., with molecular weight of 70-95 kDa.
  • HY-P78390
    B7-H4 Protein, Human (HEK293, His-Avi)

    B7H4; B7-H4; B7S1; B7h.5; B7x; FLJ22418; VTCN1; PRO1291

    		Human HEK293
    B7-H4 protein acts as a negative regulator, inhibiting T-cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it collaborates with regulatory T-cells to suppress tumor-associated antigen-specific T-cell immunity. B7-H4's involvement extends to promoting epithelial cell transformation, showcasing its multifaceted role in modulating immune responses and processes linked to tumor development. B7-H4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived B7-H4 protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of B7-H4 Protein, Human (HEK293, His-Avi) is 230 a.a., with molecular weight of 52-68 kDa.
  • HY-P74395
    B7-H4 Protein, Human (HEK293, His)

    V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

    		Human HEK293
    The B7-H4 protein acts as a negative regulator, inhibiting T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Human (HEK293, His) is the recombinant human-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Human (HEK293, His) is 230 a.a., with molecular weight of 43-48 kDa.
  • HY-P77541
    B7-H4 Protein, Human (Biotinylated, HEK293, His)

    V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

    		Human HEK293
    The B7-H4 protein acts as a negative regulator, inhibiting T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Human (Biotinylated, HEK293, His) is 230 a.a., with molecular weight of ~26.8 KDa.
  • HY-P74393
    B7-H4 Protein, Mouse (sf9, His)

    V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

    		Mouse Sf9 insect cells
    The B7-H4 protein acts as a negative regulator and inhibits T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. Significant significance can be observed when expressed on tumor macrophages, cooperating with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Mouse (sf9, His) is the recombinant mouse-derived B7-H4 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of B7-H4 Protein, Mouse (sf9, His) is 228 a.a., with molecular weight of ~26.6 kDa.
  • HY-P75485
    B7-H4 Protein, Rat (HEK293, His)

    V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4

    		Rat HEK293
    The B7-H4 protein acts as a negative regulator, inhibiting T cell activation, proliferation, cytokine production, and cytotoxicity. When expressed on tumor macrophages, it cooperates with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity and create an immunosuppressive microenvironment. B7-H4 Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Rat (HEK293, His) is 228 a.a., with molecular weight of ~26.6 kDa.
  • HY-P7643
    B7-H4 Protein, Rhesus macaque (HEK293, Fc)

    rRhB7-H4, C-Fc; B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1

    		Rhesus Macaque HEK293
    B7-H4 Protein, Rhesus macaque (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.
Cat. No. Product Name Effect Purity