Chelators
Chelating Agents
Chelators are chemical compounds that form stable ring-like structures with metal ions through multidentate coordination, exemplified by agents like EDTA and DTPA. By effectively sequestering metal ions, they are widely utilized in fields such as disease treatment, heavy metal detoxification, positron emission tomography (PET), and magnetic resonance imaging (MRI).
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Chelators Verwandte Produkte (174)
Verwandte Produkte (174)
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Deferoxamine mesylate
0 ImagesDeferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.
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Deferoxamine
0 ImagesSynonyms: Deferoxamine B; Deferriferrioxamine B; DeferrioxamineDeferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.
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DOTA-NHS-ester
0 ImagesArt. -Nr.: HY-128890CAS. Nr.: 170908-81-3DOTA-NHS-ester is a bifunctional reagent containing a DOTA chelating group and an NHS ester. DOTA-NHS-ester can be conjugated to proteins/antibodies/HSA via primary amino groups for radiolabeling with radiometals, and when combined with 16-amino-1-hexadecanethiol hydrochloride, it enables the construction of self-assembled monolayers on gold surfaces for lectin microarrays. DOTA-NHS-ester can be used to prepare DOTA-HSA-Z (HER2:342) imaging probes, as well as to construct Trop2-targeted radiotherapeutic and diagnostic probes for pancreatic cancer.
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Deferasirox
0 ImagesSynonyms: ICL 670Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.
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DOTA-tri(t-butyl ester)
0 ImagesDOTA-tri(t-butyl ester) belongs to the DOTA class of chelating agents. DOTA-tri(t-butyl ester) is a key raw material for synthesizing nanospherical magnetic resonance imaging (MRI) contrast agents, which are used in MR angiography and tumor angiogenesis imaging.
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Maleimide-DOTA
0 ImagesSynonyms: Maleimido-mono-amide-DOTAMaleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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NOTA-NHS ester
0 ImagesArt. -Nr.: HY-W087028CAS. Nr.: 1338231-09-6NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 (HY-P4810) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[18F]. The uptake of Al[18F]NOTA-T140 in tumors is correlated with the expression level of CXCR4. Al[18F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling.
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8-Hydroxyquinoline
0 Images8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice.
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Clioquinol
0 ImagesSynonyms: Iodochlorohydroxyquinoline; IodochlorhydroxyquinClioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic. Clioquinol is a chelator that binds to Zn2+ and Cu2+ with a greater affinity than it binds to Ca2+ and Mg2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease.
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p-SCN-Bn-DOTA
0 Imagesp-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunoresearch of tumor.
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CIL56
0 ImagesCIL56 is a potent and selective ferroptosis inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).
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Maleimide-NOTA
0 ImagesMaleimide-NOTA is a chelate. Maleimide-NOTA can be site-specifically coupled to the hPD-L1 nanobody bearing the Cys-tag. Maleimide-NOTA can specifically conjugate to A20FMDV2 (HY-P1654). The [68Ga]Ac-CG6 formed by the conjugation of 68Ga radiolabeled Maleimide-NOTA with A20FMDV2 can be used for PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma.
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BAPTA tetrasodium
0 ImagesBAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
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DOTAGA-anhydride
0 ImagesDOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging.
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DOTA-PEG5-azide
0 ImagesDOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Pyridoxal isonicotinoyl hydrazone
0 ImagesPyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia).
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DOTA-tris(tBu)ester NHS ester
0 ImagesDOTA-tris(tBu)ester NHS ester is a bifunctional precursor to a DOTA-based chelating agent. DOTA-tris(tBu)ester NHS ester can be used to label primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, and upon deprotection forms stable complexes with metal ions for applications in molecular imaging.
