70-51-9
70-51-9
Chemical Structure
Deferoxamine
Synonym(s): Deferoxamine B; Deferriferrioxamine B; Deferrioxamine
- CAS No.: 70-51-9
- Formula:C25H48N6O8
- Molecular Weight:560.68
IUPAC Name: N1-(5-aminopentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide
InChIKey: UBQYURCVBFRUQT-UHFFFAOYSA-N
SMILES: O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O
Biological Activity: Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Deferoxamine | 99.57% | Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19. | ||||||||||||||||||||
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Deferoxamine (Standard) | 96.37% | Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19. | ||||||||||||||||||||
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Schizokinen | Schizokinen is an orally active iron chelator that chelates ferric iron and ferrous iron via hydroxamate groups, while also chelating cadmium and binding copper for detoxification; Schizokinen reduces labile iron levels, decreases reactive oxygen species, and scavenges free radicals, and it also binds gallium with high affinity. Schizokinen is selectively taken up by bacteria (bacterial), with higher uptake levels in Gram-positive bacteria and negligible uptake in fungi, and its uptake is upregulated under iron-starvation conditions, making it useful for research related to iron overload and bacterial infections. | |||||||||||||||||||||
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AMXT-1501 | 99.81% | AMXT-1501 is a Bacterial agent and polyamine transport system inhibitor. AMXT-1501 targets membrane phospholipids and exhibits antibacterial activity against a variety of Gram-positive and Gram-negative multidrug-resistant bacteria. AMXT-1501 inhibits capsular biosynthesis in Streptococcus pneumoniae. AMXT-1501 targets ornithine decarboxylase and polyamines to inhibit the proliferation of neuroblastoma cells. AMXT-1501 in combination with DFMO (HY-B0744) induces Apoptosis in neuroblastoma cells. AMXT-1501 is applicable to research related to multidrug-resistant bacterial infections, pneumococcal infections, Streptococcus pneumoniae infections, and neuroblastoma. | ||||||||||||||||||||
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AMXT-1501 tetrahydrochloride | 99.77% | AMXT-1501 tetrahydrochloride is a Bacterial agent and polyamine transport system inhibitor. AMXT-1501 tetrahydrochloride targets membrane phospholipids and exhibits antibacterial activity against a variety of Gram-positive and Gram-negative multidrug-resistant bacteria. AMXT-1501 tetrahydrochloride inhibits capsular biosynthesis in Streptococcus pneumoniae. AMXT-1501 tetrahydrochloride targets ornithine decarboxylase and polyamines to inhibit the proliferation of neuroblastoma cells. AMXT-1501 tetrahydrochloride in combination with DFMO (HY-B0744) induces Apoptosis in neuroblastoma cells. AMXT-1501 tetrahydrochloride is applicable to research related to multidrug-resistant bacterial infections, pneumococcal infections, Streptococcus pneumoniae infections, and neuroblastoma. | ||||||||||||||||||||
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Mal-Deferoxamine | 95.0% | Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields. | ||||||||||||||||||||
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GABA-palmitamide | 98.54% | GABA-palmitamide is a GABA-responsive compound. GABA-palmitamide exhibits a dose-dependent bidirectional regulatory effect on the stereotyped behavior induced by Apomorphine (HY-12723): high doses inhibit motor behavior, while low doses enhance stereotyped behaviors in the oral cavity. GABA-palmitamide can be used in research on behavior regulation. | ||||||||||||||||||||
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Desferrioxamine T1 | Desferrioxamine T1 is an agent that binds iron and aluminium. | |||||||||||||||||||||
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Deferoxamine mesylate (Standard) | 99.47% | Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19. | ||||||||||||||||||||
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Arthrobactin | Arthrobactin is a ferric ionophore that can be produced by Arthrobacter pascens. | |||||||||||||||||||||
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PAMAM Dendrimer G0.0 amine (20% in methanol) | PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems. | |||||||||||||||||||||
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Magnesium ionophore III | 98.05% | Magnesium ionophore III (ETH 4030) is an ionophore that has the activity of regulating the intracellular magnesium concentration. Magnesium ionophore III can promote the permeability of cell membranes to magnesium ions and enhance cell functions and metabolic activities. Magnesium ionophore III is also used to study the importance of magnesium ions in biological processes and its effects on cell physiology. | ||||||||||||||||||||
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References
- [1]. Duscher D, et al. Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e. [Content Brief]
- [2]. Dongiovanni P, et al. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol. 2008 Mar;172(3):738-47. [Content Brief]
- [3]. Wang G, et al. In vitro assessment of deferoxamine on mesenchymal stromal cells from tumor and bone marrow. Environ Toxicol Pharmacol. 2017 Jan;49:58-64. [Content Brief]
- [4]. Wu Y, et al. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochem Int. 2010 Oct;57(3):198-205. [Content Brief]
- [5]. Bellotti D, et al. Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator. Molecules. 2021 May 28;26(11):3255. [Content Brief]
