1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor

GABA Receptor

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor Related Products (42):

Cat. No. Product Name Effect Purity
  • HY-N0219
    (+)-Bicuculline Antagonist 99.92%
    (+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.
  • HY-15399
    Vigabatrin Inhibitor >98.0%
    Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
  • HY-17354
    (R)-Baclofen Agonist
    (R)-Baclofen(STX209) is a selective GABAB receptor agonist.
  • HY-11048
    NS11394 Activator
    NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
  • HY-B0799
    Dihydroergotoxine mesylate Modulator >98.0%
    Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.
  • HY-16716
    Basmisanil Inhibitor 99.65%
    Basmisanil is a highly selective GABAAα5 negative allosteric modulator.
  • HY-100140
    Pipequaline Agonist 98.61%
    Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
  • HY-B0007
    Baclofen Agonist 99.44%
    Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.
  • HY-B0100
    Etomidate Agonist 99.21%
    Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.
  • HY-B0355
    Ginkgolide A Antagonist >98.0%
    Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
  • HY-B0009
    Flumazenil Antagonist
    Flumazenil(Ro 15-1788) is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors.
  • HY-B1122
    L-Cycloserine Inhibitor
    L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.
  • HY-19371
    Lorediplon Modulator
    Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep.
  • HY-B0837
    Emamectin Benzoate Activator
    Emamectin Benzoate works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods.
  • HY-B0696A
    Tiagabine hydrochloride Inhibitor 98.20%
    Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
  • HY-B1833
    Afloqualone Agonist >98.0%
    Afloqualone is a agonist of GABA receptor .
  • HY-14840
    Phenylpiracetam Activator 99.90%
    Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated derivative of the nootropic drug piracetam. It is used as a stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.
  • HY-B0340
    Nefiracetam Activator
    Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.
  • HY-B1242
    Pentylenetetrazol Antagonist 99.80%
    Pentylenetetrazol is a GABA(A) receptor antagonist, kindles model of epilepsy.
  • HY-14953
    AWD 131-138 Activator 99.13%
    AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.