Signaling Pathway

GABA Receptor

GABA Receptor

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The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor Inhibitors & Modulators (37)

Product Name Catalog No. Brief Description
(+)-Bicuculline

HY-N0219

(+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.

(R)-Baclofen

HY-17354

(R)-Baclofen(STX209) is a selective GABAB receptor agonist.

(R)-Baclofen hydrochloride

HY-17354A

(R)-Baclofen hydrochloride is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.

Acamprosate calcium

HY-17030

Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.

Afloqualone

HY-B1833

Afloqualone is a agonist of GABA  receptor .

alpha-Asarone

HY-N0700

Alpha-Asarone is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.

AWD 131-138

HY-14953

AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

Baclofen

HY-B0007

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.

Basmisanil

HY-16716

Basmisanil is a highly selective GABAAα5 negative allosteric modulator.

Bemegride

HY-B1326

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.

Dihydroergotoxine mesylate

HY-B0799

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.

Emamectin Benzoate

HY-B0837

Emamectin Benzoate works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods.

Etifoxine

HY-16579A

Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons.

Etifoxine hydrochloride

HY-16579

Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons.

Etomidate

HY-B0100

Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Etomidate hydrochloride

HY-B0100A

Etomidate Hcl(R16659 Hcl) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.

Flumazenil

HY-B0009

Flumazenil(Ro 15-1788) is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors.

Ginkgolide A

HY-B0355

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.

Indiplon

HY-18995

Indiplon is a potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively).

L-655708

HY-14426

L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).