1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor

GABA Receptor

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor Related Products (41):

Cat. No. Product Name Effect Purity
  • HY-N0219
    (+)-Bicuculline Antagonist
    (+)-Bicuculline, a convulsant alkaloid, is the antagonist of GABA.
  • HY-17354
    (R)-Baclofen Agonist
    (R)-Baclofen(STX209) is a selective GABAB receptor agonist.
  • HY-15399
    Vigabatrin Inhibitor
    Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
  • HY-B0007
    Baclofen Agonist
    Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.
  • HY-B0355
    Ginkgolide A Antagonist
    Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.
  • HY-16716
    Basmisanil Inhibitor
    Basmisanil is a highly selective GABAAα5 negative allosteric modulator.
  • HY-B0009
    Flumazenil Antagonist
    Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
  • HY-B1122
    L-Cycloserine Inhibitor
    L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.
  • HY-B0837
    Emamectin Benzoate Activator
    Emamectin Benzoate works as a chloride channel activator by binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods.
  • HY-B0696A
    Tiagabine hydrochloride Inhibitor
    Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
  • HY-11048
    NS11394 Activator
    NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
  • HY-14840
    Phenylpiracetam Activator
    Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated derivative of the nootropic drug piracetam. It is used as a stimulant nootropic drug that can be up to 30-60 times more potent than piracetam.
  • HY-B0100
    Etomidate Agonist
    Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.
  • HY-16579
    Etifoxine hydrochloride Activator
    Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors.
  • HY-14953
    AWD 131-138 Activator
    AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
  • HY-14426
    L-655708 Agonist
    L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
  • HY-B0033
    Vigabatrin Hydrochloride Inhibitor
    Vigabatrin Hcl(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
  • HY-B0546
    Procaine Inhibitor
    Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.
  • HY-B0340
    Nefiracetam Activator
    Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.
  • HY-B0546A
    Procaine hydrochloride Inhibitor
    Procaine Hydrochloride is a local anesthetic drug of the amino ester group.