2. Apoptosis PI3K/Akt/mTOR Neuronal Signaling GPCR/G Protein Membrane Transporter/Ion Channel
  3. Apoptosis PI3K Akt mTOR Adrenergic Receptor GABA Receptor Beta-secretase Bcl-2 Family
  4. Scoulerine hydrochloride

Scoulerine hydrochloride  (Synonyms: (-)-Scoulerine hydrochloride; Discretamine hydrochloride)

Cat. No.: HY-N1255A
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Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine hydrochloride mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine hydrochloride effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine hydrochloride also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine hydrochloride is applicable to research related to leukemia, ovarian cancer, and colorectal cancer.

For research use only. We do not sell to patients.

Scoulerine hydrochloride

Scoulerine hydrochloride Chemical Structure

CAS No. : 51486-68-1

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Scoulerine hydrochloride Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

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α adrenergic receptor β adrenergic receptor

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BACE1 BACE2

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Description

Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine hydrochloride mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine hydrochloride effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine hydrochloride also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine hydrochloride is applicable to research related to leukemia, ovarian cancer, and colorectal cancer[1][2][3].

IC50 & Target[1][2]

mTOR

 

Bak

 

BACE1

 

Alpha-1D adrenergic receptor

 

In Vitro

Scoulerine (1-50 μM; 72 h) exhibits antiproliferative activity against human lung cancer A549 cells, ovarian cancer A2780 cells, breast cancer SK-BR-3 cells, and MCF-7 cells. Low concentrations (1 μM, 5 μM) exert little effect or cause slight delay on cell proliferation, while high concentrations (10 μM, 20 μM, 50 μM) significantly inhibit cell proliferation[2].
Scoulerine (2.5-20 μM; 24 h) induces apoptosis in Jurkat and MOLT-4 leukemia cells, with dose-dependent increases in both early and late apoptosis rates, and DNA fragmentation can be detected via TUNEL assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Scoulerine hydrochloride Related Antibodies

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: Jurkat, MOLT-4, Raji, HL-60, U-937, HEL 92.1.7, A549, A2780, SK-BR-3, MCF-7
Concentration: 1 μM, 5 μM, 10 μM, 15 μM, 20 μM, 50 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Reduced the viability and proliferation of leukemic cells in a dose-dependent manner within 24 h, and the reduction was more pronounced at 48 h.
For adherent cell lines, low concentrations (1 μM, 5 μM) had no significant effect or slightly delayed proliferation, while high concentrations (10 μM, 20 μM, 50 μM) exerted a potent antiproliferative effect over 72 h.
The IC50 values of scoulerine against human leukemic cells ranged from 2.7 to 6.5 μM as determined by XTT assay.
IC50 values: 2.7 ± 0.1 μM (Jurkat), 4.2 ± 0.2 μM (HL-60), 4.7 ± 0.2 μM (MOLT-4), 4.8 ± 0.3 μM (U-937), 6.3 ± 0.8 μM (HEL 92.1.7), 6.5 ± 0.7 μM (Raji).

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[2]

Cell Line: A549
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 h
Result: Disrupted the microtubule structure at 10 μM and 20 μM, leading to dense aggregation of microtubules around cell nuclei and reduced density at the cell periphery.
At 5 μM, the tubulin network remained almost intact similar to the control cells.
Molecular Weight

363.84

Formula

C19H22ClNO4
CAS No.
SMILES

OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[C@]24[H])C4=C1.Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Scoulerine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scoulerine51486-68-1(-)-ScoulerineDiscretamineApoptosisPI3KAktmTORAdrenergic ReceptorGABA ReceptorBeta-secretaseBcl-2 FamilyPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinBeta ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBACEβ-SecretasePI3K/Akt/mTOR axisepithelial-mesenchymal transitioncolorectal cancer cellsα1D-adrenoreceptorBACE1GABA receptorsovarian cancer mouse modelsPlasmodium falciparumleukemic cellsovarian cancer xenograft mouse modelsInhibitorinhibitorinhibit

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