1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3K Inhibitors

PI3K Inhibitors

PI3Kα

PI3Kβ

PI3Kγ

PI3Kδ

PI3KC2α

PI3KC2β

PI3KC2γ

Vps34

PI3K

PI3KC3

p120γ

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PI3K Inhibitors, Activators & Modulators
Product Name PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ Purity
3-Methyladenine    
PtdIns3Kγ, IC50: 60 μM (Cell Assay)
       
Vps34, IC50: 25 μM (Cell Assay)
      99.91%
LY294002
p110α, IC50: 0.5 μM
p110β, IC50: 0.97 μM
 
p110δ, IC50: 0.57 μM
              99.95%
Quercetin  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 3 μM
PI3Kδ, IC50: 2.4 μM
              98.06%
Alpelisib
p110α, IC50: 5 nM
p110α-H1047R, IC50: 4 nM
p110α-E545K, IC50: 4 nM
p110β, IC50: 1200 nM
p110γ, IC50: 250 nM
p110δ, IC50: 290 nM
              99.95%
740 Y-P                
PI3K
    99.67%
Wortmannin                
PI3K, IC50: 3 nM
    99.86%
AZD-7648    
PI3Kγ, IC50: 1.37 μM
                99.86%
Buparlisib
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.90%
Copanlisib
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              99.50%
Dactolisib
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.94%
Inavolisib
PI3Kα, IC50: 0.038 nM
                    99.85%
Idelalisib
p110α, IC50: 820 nM
p110β, IC50: 565 nM
p110γ, IC50: 89 nM
p110δ, IC50: 2.5 nM
     
hVps34, IC50: 978 nM
      99.78%
Pictilisib
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.80%
SAR405              
Vps34, IC50: 1.2 nM
Vps34, Kd: 1.5 nM
      98.99%
Duvelisib
p110α, IC50: 1602 nM
p110β, IC50: 85 nM
p110γ, IC50: 27.4 nM
p110δ, IC50: 2.5 nM
              99.88%
Eganelisib
PI3Kα, IC50: 3.2 μM
PI3Kβ, IC50: 3.5 μM
PI3Kγ, IC50: 16 nM
                99.69%
YM-201636
p110α, IC50: 3.3 μM
                    98.06%
α-Linolenic acid                
PI3K
    99.56%
Omipalisib
p110α, Ki: 0.019 nM
p110α-H1047R, Ki: 0.009 nM
p110α-E545K, Ki: 0.008 nM
p110α-E542K, Ki: 0.008 nM
p110β, Ki: 0.13 nM
p110γ, Ki: 0.06 nM
p110δ, Ki: 0.024 nM
              99.93%
Recilisib                
PI3K
    99.14%
PI-103
p110α, IC50: 8 nM
p110β, IC50: 88 nM
p110γ, IC50: 150 nM
p110δ, IC50: 48 nM
PI3KC2α, IC50: 1 μM
PI3KC2β, IC50: 26 nM
 
hsVPS34, IC50: 2.3 μM
      98.93%
Taselisib
PI3Kα, Ki: 0.29 nM
PI3Kβ, Ki: 9.1 nM
PI3Kγ, Ki: 0.97 nM
PI3Kδ, Ki: 0.12 nM
              99.86%
Isorhamnetin                
PI3-K
    99.95%
Fimepinostat
PI3Kα, IC50: 19 nM
PI3Kβ, IC50: 54 nM
PI3Kγ, IC50: 311 nM
PI3Kδ, IC50: 39 nM
              99.95%
Vps34-IN-1              
Vps34, IC50: 25 nM
      99.56%
Copanlisib dihydrochloride
PI3Kα, IC50: 0.5 nM
PI3Kβ, IC50: 3.7 nM
PI3Kγ, IC50: 6.4 nM
PI3Kδ, IC50: 0.7 nM
              99.55%
Umbralisib
PI3Kα, Kd: >10000 nM
PI3Kβ, Kd: >10000 nM
PI3Kγ, Kd: 1400 nM
PI3Kδ, EC50: 22.2 nM
PI3Kδ, Kd: 6.2 nM
              98.69%
GSK2636771  
PI3Kβ, Ki: 0.89 nM
PI3Kβ, IC50: 5.2 nM
                  99.83%
hSMG-1 inhibitor 11j
PI3Kα, IC50: 92 nM
 
PI3Kγ, IC50: 60 nM
                99.81%
Quercetin dihydrate  
PI3Kβ, IC50: 5.4 μM
PI3Kγ, IC50: 2.4 μM
PI3Kδ, IC50: 3.0 μM
             
ZSTK474
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 44 nM
PI3Kγ, IC50: 49 nM
PI3Kδ, IC50: 4.6 nM
              99.88%
Autophinib              
Vps34, IC50: 19 nM
      99.56%
TGX-221  
p110β, IC50: 8.5 nM
 
p110δ, IC50: 211 nM
              99.74%
Gedatolisib
PI3Kα, IC50: 0.4 nM
PI3Kα-H1047R, IC50: 0.6 nM
PI3Kα-E545K, IC50: 0.6 nM
PI3Kβ, IC50: 6 nM
PI3Kγ, IC50: 5.4 nM
PI3Kδ, IC50: 6 nM
              99.68%
PF-04691502
PI3Kα, Ki: 1.8 nM
PI3Kβ, Ki: 2.1 nM
PI3Kγ, Ki: 1.9 nM
PI3Kδ, Ki: 1.6 nM
              99.91%
Vps34-PIK-III
PI(3)Kα, IC50: 3.96 μM
 
PI(3)Kγ, IC50: 3.04 μM
PI(3)Kδ, IC50: 1.2 μM
     
Vps34, IC50: 18 nM
      99.02%
AZD8186
PI3Kα, IC50: 35 nM
PI3Kβ, IC50: 4 nM
PI3Kγ, IC50: 675 nM
PI3Kδ, IC50: 12 nM
              99.97%
PIK-90
p110α, IC50: 11 nM
p110β, IC50: 350 nM
p110γ, IC50: 18 nM
p110δ, IC50: 58 nM
PI3KC2α, IC50: 47 nM
PI3KC2β, IC50: 64 nM
 
hsVPS34, IC50: 830 nM
      99.70%
Samotolisib
PI3Kα, IC50: 6.07 nM
PI3Kβ, IC50: 77.6 nM
PI3Kγ, IC50: 23.8 nM
PI3Kδ, IC50: 38 nM
              99.42%
PIK-93
p110α, IC50: 39 nM
p110β, IC50: 590 nM
p110γ, IC50: 16 nM
p110δ, IC50: 120 nM
PI3KC2α, IC50: 16 μM
PI3KC2β, IC50: 140 nM
 
hsVPS34, IC50: 320 nM
      99.81%
AZD 6482
PI3Kα, IC50: 136 nM
PI3Kβ, IC50: 0.69 nM
PI3Kγ, IC50: 47.8 nM
PI3Kδ, IC50: 13.6 nM
 
PI3K-C2β, IC50: 54.1 nM
 
hVps34, IC50: 3390 nM
      99.56%
Esculetin                
PI3K
    99.59%
AS-605240
PI3Kα, IC50: 60 nM
PI3Kβ, IC50: 270 nM
PI3Kγ, IC50: 8 nM
PI3Kγ, Ki: 7.8 nM
PI3Kδ, IC50: 300 nM
              98.51%
Voxtalisib
p110α, IC50: 39 nM
p110β, IC50: 113 nM
p110γ, IC50: 9 nM
p110δ, IC50: 43 nM
              98.81%
PIK-75 hydrochloride
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
      99.72%
Dihydrocapsaicin                
PI3K
    99.86%
CNX-1351
PI3Kα, IC50: 6.8 nM
PI3Kβ, IC50: 166 nM
PI3Kγ, IC50: 3020 nM
PI3Kδ, IC50: 240.3 nM
              99.88%
1,3-Dicaffeoylquinic acid                
PI3K
    98.85%
Apitolisib
PI3Kα, IC50: 5 nM
PI3Kβ, IC50: 27 nM
PI3Kγ, IC50: 14 nM
PI3Kδ, IC50: 7 nM
              99.65%
Dactolisib Tosylate
p110α, IC50: 4 nM
p110α-H1047R, IC50: 4.6 nM
p110α-E545K, IC50: 5.7 nM
p110β, IC50: 75 nM
p110γ, IC50: 5 nM
p110δ, IC50: 7 nM
              99.87%
Parsaclisib      
PI3Kδ, IC50: 1 nM
              99.31%
Bimiralisib
PI3Kα, IC50: 33 nM
PI3Kα-H1047R, IC50: 36 nM
PI3Kα-E545K, IC50: 136 nM
PI3Kα-E542K, IC50: 63 nM
PI3Kβ, IC50: 661 nM
PI3Kγ, IC50: 708 nM
PI3Kδ, IC50: 451 nM
     
Vps34, IC50: 6486 nM
      99.80%
GO-203 TFA                
PI3K
    99.28%
PI3K-IN-1                
PI3K
    99.93%
TG100-115    
PI3Kγ, IC50: 83 nM
PI3Kδ, IC50: 235 nM
              99.01%
Sonolisib
p110α, IC50: 0.1 nM
   
p110δ, IC50: 2.9 nM
           
p120γ, IC50: 1 nM
99.00%
hSMG-1 inhibitor 11e
PI3Kα, IC50: 61 nM
 
PI3Kγ, IC50: 92 nM
                99.18%
Serabelisib
p110α, IC50: 15 nM
p110β, IC50: 4500 nM
p110γ, IC50: 1900 nM
p110δ, IC50: 13900 nM
              99.21%
AS-252424
PI3Kα, IC50: 935 nM
PI3Kβ, IC50: 20 μM
PI3Kγ, IC50: 30 nM
PI3Kδ, IC50: 20 μM
              99.71%
IC-87114  
PI3Kβ, IC50: 75 μM
PI3Kγ, IC50: 29 μM
PI3Kδ, IC50: 0.5 μM
              99.83%
VS-5584
PI3Kα, IC50: 16 nM
PI3Kβ, IC50: 68 nM
PI3Kγ, IC50: 25 nM
PI3Kδ, IC50: 42 nM
     
Vps34, IC50: 7470 nM
      99.14%
Nemiralisib
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kγ, pIC50: 5.2
PI3Kδ, pKi: 9.9
              99.80%
BGT226 maleate
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
PI3Kγ, IC50: 38 nM
                99.87%
Sophocarpine                
PI3K
    98.63%
PI3K/AKT-IN-1    
PI3Kγ, IC50: 6.99 μM
PI3Kδ, IC50: 4.01 μM
              99.62%
GSK1059615
PI3Kα, IC50: 0.4 nM
PI3Kβ, IC50: 0.6 nM
PI3Kγ, IC50: 2 nM
PI3Kδ, IC50: 5 nM
              ≥99.0%
Linperlisib      
PI3Kδ, IC50: 6.4 nM
              99.51%
Leniolisib
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kγ, IC50: 2.57 μM
PI3Kδ, IC50: 11 nM
              99.19%
Flupentixol dihydrochloride
PI3Kα, IC50: 127 nM
                    99.73%
PKI-402
PI3Kα, IC50: 2 nM
PI3Kα-H1047R, IC50: 3 nM
PI3Kα-E545K, IC50: 3 nM
PI3Kβ, IC50: 7 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 14 nM
              98.43%
A66
p110α, IC50: 32 nM
p110α E545K, IC50: 30 nM
p110α H1047R, IC50: 43 nM
 
p110γ, IC50: 3480 nM
   
PI3K-C2β, IC50: 462 nM
          99.68%
KU-0060648
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 0.5 nM
PI3Kγ, IC50: 0.594 μM
PI3Kδ, IC50: 0.1 nM
              99.39%
AMG319
PI3Kα, IC50: 33 μM
PI3Kβ, IC50: 2.7 μM
PI3Kγ, IC50: 850 nM
PI3Kδ, IC50: 18 nM
              98.27%
Zandelisib      
PI3Kδ, IC50: 3.5 nM
              99.90%
Tenalisib    
PI3Kγ, IC50: 33 nM
PI3Kδ, IC50: 25 nM
              98.83%
AZD3458
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kγ, pIC50: 9.1
PI3Kδ, pIC50: 6.5
PI3KC2α, pIC50: 5
PI3KC2β, pIC50: 7.5
PI3KC2γ, pIC50: 5.5
   
PI3KC3, pIC50: 5.1
  99.82%
GDC-0326
PI3Kα, Ki: 0.2 nM
PI3Kβ, Ki: 26.6 nM
PI3Kγ, Ki: 10.2 nM
PI3Kδ, Ki: 4 nM
              99.92%
PI-103 Hydrochloride
p110α, IC50: 2 nM
p110β, IC50: 3 nM
p110γ, IC50: 15 nM
p110δ, IC50: 3 nM
              98.00%
PI4KIIIbeta-IN-9
PI3Kα, IC50: 2 μM
 
PI3Kγ, IC50: 1046 nM
PI3Kδ, IC50: 152 nM
   
PI3KC2γ, IC50: 1 μM
        99.01%
PQR530
PI3Kα, Kd: 0.84 nM
PI3Kβ, Kd: 6.1 nM
PI3Kγ, Kd: 10 nM
PI3Kδ, Kd: 11 nM
 
PI3KC2β, Kd: 100 nM
          99.98%
BGT226
PI3Kα, IC50: 4 nM
PI3Kβ, IC50: 63 nM
PI3Kγ, IC50: 38 nM
                99.51%
HS-173
PI3Kα, IC50: 0.8 nM
                    99.04%
PI3K-IN-30
PI3Kα, IC50: 5.1 nM
PI3Kβ, IC50: 136 nM
PI3Kγ, IC50: 30.7 nM
PI3Kδ, IC50: 8.9 nM
              98.21%
AMG 511
PI3Kα, Ki: 4 nM
PI3Kβ, Ki: 6 nM
PI3Kγ, Ki: 1 nM
PI3Kδ, Ki: 2 nM
              99.38%
Deoxyshikonin                
PI3K
    99.96%
AZD-8835
PI3Kα, IC50: 6.2 nM
PI3Kα-E545K, IC50: 6 nM
PI3Kα-H1047R, IC50: 5.8 nM
PI3Kβ, IC50: 431 nM
PI3Kγ, IC50: 90 nM
PI3Kδ, IC50: 5.7 nM
              98.63%
CZC24832  
PI3Kβ, IC50: 1.1 μM
PI3Kγ, IC50: 27 nM
PI3Kδ, IC50: 8.194 μM
              99.35%
GNE-317                
PI3K
    99.14%
Pilaralisib
PI3Kα, IC50: 39 nM
PI3Kβ, IC50: 383 nM
PI3Kγ, IC50: 23 nM
PI3Kδ, IC50: 36 nM
     
Vps34, IC50: 6974 nM
      99.69%
BAY1082439
PI3Kα
PI3Kβ
 
PI3Kδ
              98.02%
SAR-260301
PI3Kα, IC50: 1539 nM
PI3Kβ, IC50: 23 nM
PI3Kγ, IC50: 10000 nM
PI3Kδ, IC50: 468 nM
   
PI3KC2γ, IC50: 3812 nM
Vps34, IC50: 183 nM
      99.37%
alpha-Bisabolol                
PI3K
   
4-Methylbenzylidene camphor                
PI3K
    99.87%
PI-3065
p110α, IC50: 910 nM
p110β, IC50: 600 nM
 
p110δ, IC50: 5 nM
              98.97%
Vps34-IN-2              
Vps34, IC50: 2 nM
      99.81%
Acalisib
p110α, IC50: 5441 nM
p110β, IC50: 3377 nM
p110γ, IC50: 1389 nM
p110δ, IC50: 12.7 nM
     
hVps34, IC50: 12682 nM
      99.98%
IITZ-01    
PI3Kγ, IC50: 2.62 μM
                99.05%
SF2523
PI3Kα, IC50: 34 nM
 
PI3Kγ, IC50: 158 nM
                98.25%
CGS 15943    
p110γ, IC50: 1.1 μM
p110δ, IC50: 8.47 μM
              99.96%
AZ2
PI3Kα, pIC50: 5.1
PI3Kβ, pIC50: 4.5
PI3Kγ, pIC50: 9.3
PI3Kδ, pIC50: 6.6
              99.38%
Buparlisib Hydrochloride
p110α, IC50: 52 nM
p110α-H1047R, IC50: 58 nM
p110α-E545K, IC50: 99 nM
p110β, IC50: 166 nM
p110γ, IC50: 262 nM
p110δ, IC50: 116 nM
     
Vps34, IC50: 2.4 μM
      99.88%
MTX-211                
PI3K
    ≥98.0%
PF-06843195
PI3Kα, IC50: 18 nM (in Rat1 fibroblasts)
PI3Kα, Ki: 0.018 nM
PI3Kβ, IC50: 360 nM (in Rat1 fibroblasts)
 
PI3Kδ, IC50: 160 nM (in Rat1 fibroblasts)
PI3Kδ, Ki: 0.28 nM
              99.06%
CAY10505    
PI3Kγ, IC50: 30 nM (Neurons)
                99.75%
Pictilisib dimethanesulfonate
p110α, IC50: 3 nM
p110α-H1047R, IC50: 3 nM
p110α-E545K, IC50: 3 nM
p110β, IC50: 33 nM
p110γ, IC50: 75 nM
p110δ, IC50: 3 nM
              99.70%
ETP-45658
PI3Kα, IC50: 22.0 nM
PI3Kβ, IC50: 129.0 nM
PI3Kγ, IC50: 717.3 nM
PI3Kδ, IC50: 39.8 nM
              98.05%
Izorlisib
PI3Kα, IC50: 14 nM
PI3Kα-H1047R, IC50: 5.6 nM
PI3Kα-E545K, IC50: 6.7 nM
PI3Kα-E542K, IC50: 6.7 nM
PI3Kβ, IC50: 120 nM
PI3Kγ, IC50: 36 nM
PI3Kδ, IC50: 500 nM
 
PI3KC2β, IC50: 5.3 μM
          98.93%
Duvelisib (R enantiomer)                
PI3K
   
Seletalisib      
PI3Kδ, IC50: 12 nM
              98.88%
TG 100713
PI3Kα, IC50: 165 nM
PI3Kβ, IC50: 215 nM
PI3Kγ, IC50: 50 nM
PI3Kδ, IC50: 24 nM
              99.49%
YH-306                
PI3K
    98.01%
Brevianamide F
PI3Kα, IC50: 4.8 μM
                    99.30%
NSC781406
PI3Kα, IC50: 2 nM
PI3Kβ, IC50: 9.4 nM
PI3Kγ, IC50: 2.7 nM
PI3Kδ, IC50: 14 nM
              99.97%
Roginolisib
PI3Kα, IC50: 18500 nM
PI3Kβ, IC50: 2850 nM
 
PI3Kδ, IC50: 145 nM
              99.89%
Risovalisib
PI3Kα, IC50: 5.9 nM
PI3Kβ, IC50: 598 nM
PI3Kγ, IC50: 225 nM
PI3Kδ, IC50: 78.7 nM
              99.39%
PI3K-IN-31
PI3Kα, IC50: 3.7 nM
PI3Kβ, IC50: 74 nM
PI3Kγ, IC50: 14.6 nM
PI3Kδ, IC50: 9.9 nM
              99.55%
PI-828
p110α, IC50: 173 nM
                    99.09%
Glaucocalyxin A                
PI3K
    99.39%
PIK-294
p110α, IC50: 10 μM
p110β, IC50: 490 nM
p110γ, IC50: 160 nM
p110δ, IC50: 10 nM
              99.90%
SRX3207
PI3Kα, IC50: 861 nM
 
PI3Kγ, IC50: 11100 nM
PI3Kδ, IC50: 1280 nM
              98.50%
AZD8154    
PI3Kγ
                99.69%
PKI-179
PI3Kα, IC50: 8 nM
PI3Kβ, IC50: 24 nM
PI3Kγ, IC50: 74 nM
PI3Kδ, IC50: 77 nM
              ≥98.0%
WYE-687
PI3K alpha, IC50: 81 nM
 
PI3K gamma, IC50: 3.11 μM
                98.10%
PI3K/mTOR Inhibitor-4
PI3Kα, IC50: 0.63 nM
PI3Kβ, IC50: 94.54 nM
PI3Kγ, IC50: 22 nM
PI3Kδ, IC50: 9.2 nM
             
NVP-BAG956
PI3Kα, IC50: 56 nM
PI3Kβ, IC50: 446 nM
PI3Kγ, IC50: 117 nM
PI3Kδ, IC50: 35 nM
              99.12%
GNE-493
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 12 nM
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 16 nM
              98.33%
Leniolisib phosphate
PI3Kα, IC50: 280 nM
PI3Kβ, IC50: 480 nM
PI3Kγ, IC50: 2.57 nM
PI3Kδ, IC50: 11 nM
              99.10%
PI3K/mTOR Inhibitor-2
PI3Kα, IC50: 3.4 nM
PI3Kβ, IC50: 34 nM
PI3Kγ, IC50: 1 nM
PI3Kδ, IC50: 16 nM
              98.25%
PF-04979064
PI3Kα, Ki: 0.13 nM
 
PI3Kγ, Ki: 0.111 nM
PI3Kδ, Ki: 0.122 nM
              99.83%
AS-604850
PI3Kα, IC50: 4.5 μM
 
PI3Kγ, IC50: 0.25 μM
PI3Kγ, Ki: 0.18 μM
                99.95%
Hederacolchiside A1                
PI3K
    99.69%
PI3Kα-IN-9
PI3Kα, IC50: 4.4 nM
PI3Kβ, IC50: 153 nM
PI3Kγ, IC50: 128 nM
PI3Kδ, IC50: 146 nM
              99.17%
Arnicolide D                
PI3K
    99.20%
CAL-130 Hydrochloride
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
              98.74%
Umbralisib hydrochloride
PI3Kα, Kd: >10000 nM
PI3Kβ, Kd: >10000 nM
PI3Kγ, Kd: 1400 nM
PI3Kδ, EC50: 22.2 nM
PI3Kδ, Kd: 6.2 nM
              98.98%
CYH33 methanesulfonate
PI3Kα, IC50: 5.9 nM
PI3Kβ, IC50: 598 nM
PI3Kγ, IC50: 225 nM
PI3Kδ, IC50: 78.7 nM
             
Parsaclisib hydrochloride      
PI3Kδ, IC50: 1 nM
              98.74%
Roginolisib hemifumarate      
PI3Kδ, IC50: 145 nM
              99.95%
Vulolisib
PI3Kα, IC50: 0.2 nM
PI3Kβ, IC50: 168 nM
PI3Kγ, IC50: 90 nM
PI3Kδ, IC50: 49 nM
              99.60%
IPI-3063
p110α, IC50: 1170 nM
p110β, IC50: 1508 nM
p110γ, IC50: 2187 nM
p110δ, IC50: 2.5 nM
              99.22%
Sophocarpine monohydrate                
PI3K
    99.15%
AQX-016A                
PI3K
    98.00%
PKI-179 hydrochloride
PI3Kα, IC50: 8 nM
PI3Kβ, IC50: 24 nM
PI3Kγ, IC50: 74 nM
PI3Kδ, IC50: 77 nM
              98.11%
BEBT-908
PI3Kα, IC50: 0.1 μM
                    99.14%
PIK-293
PI3Kα, IC50: 100 μM
PI3Kβ, IC50: 10 μM
PI3Kγ, IC50: 25 μM
PI3Kδ, IC50: 0.24 μM
              99.41%
PI4K-IN-1
PI3Kα, pIC50: 4.0
PI3Kβ, pIC50: <3.7
PI3Kγ, pIC50: 5.0
PI3Kδ, pIC50: <4.1
             
GSK-F1                
PI3KA, pIC50: 5.8
PI3KB, pIC50: 5.9
PI3KG, pIC50: 5.9
PI3KD, pIC50: 6.4
   
GNE-477
PI3Kα, IC50: 4 nM
                    98.70%
GNE-490
PI3Kα, IC50: 3.5 nM
PI3Kβ, IC50: 25 nM
PI3Kγ, IC50: 15 nM
PI3Kδ, IC50: 5.2 nM
             
Pilaralisib analogue
PI3K-alpha
                    99.67%
PI3K/mTOR Inhibitor-11
PI3Kα, IC50: 3.5 nM
   
PI3Kδ, IC50: 4.6 nM
              98.74%
LX2343                
PI3K, IC50: 15.99 μM
    99.80%
PI3Kα-IN-4
PI3Kα, IC50: 1.8 nM
                    99.83%
(S)-PI3Kα-IN-4
PI3Kα, IC50: 2.3 nM
                    99.79%
PARP/PI3K-IN-1
PI3Kα, pIC50: 8.25
PI3Kβ, pIC50: 6.54
PI3Kγ, pIC50: 6.08
PI3Kδ, pIC50: 8.13
              99.43%
NVS-PI3-4    
PI3Kγ
                99.74%
TASP0415914    
PI3Kγ, IC50: 29 nM
                99.37%
PF-4989216
PI3Kα, Ki: 0.6 nM
                    99.69%
Polygalasaponin F                
PI3K
    99.74%
AS-041164
PI3Kα, IC50: 240 nM
PI3Kβ, IC50: 1.4 μM
PI3Kγ, IC50: 70 nM
PI3Kδ, IC50: 1.7 μM
              99.32%
Gilmelisib
p110α, IC50: <1 nM
                    99.62%
ETP-46321
p110α, Ki: 2.3 nM
PI3Kα-H1047R, Ki: 2.33 nM
PI3Kα-E545K, Ki: 1.77 nM
PI3Kα-E542K, Ki: 1.89 nM
p110β, Ki: 170 nM
p110γ, Ki: 179 nM
p110δ, Ki: 14.2 nM
              99.65%
NVP-QAV-572                
PI3K, IC50: 10 nM
    98.05%
GS-9901      
PI3Kδ, IC50: 1 nM
             
Umbralisib tosylate
PI3Kα, Kd: >10000 nM
PI3Kβ, Kd: >10000 nM
PI3Kγ, Kd: 1400 nM
PI3Kδ, Kd: 6.2 nM
             
Nemiralisib hydrochloride
PI3Kα, pIC50: 5.3
PI3Kβ, pIC50: 5.8
PI3Kγ, pIC50: 5.2
PI3Kδ, pKi: 9.9
             
Umbralisib sulfate
PI3Kα, Kd: >10000
PI3Kβ, Kd: >10000
PI3Kγ, Kd: 1400
PI3Kδ, Kd: 6.2
             
PI3K/HDAC-IN-1
PI3Kα, IC50: 42 nM
PI3Kβ, IC50: 101 nM
PI3Kγ, IC50: 67 nM
PI3Kδ, IC50: 8.1 nM
             
PI3K/mTOR Inhibitor-1
PI3Kα, IC50: 20 nM
PI3Kβ, IC50: 376 nM
PI3Kγ, IC50: 204 nM
PI3Kδ, IC50: 46 nM
             
IHMT-PI3Kδ-372      
PI3Kδ, IC50: 14 nM
              99.75%
PI3K-IN-6
PI3Kα, IC50: 850 nM
PI3Kβ, IC50: 7.8 nM
 
PI3Kδ, IC50: 5.3 nM
             
PI3Kδ-IN-8
PI3Kα, IC50: 377.2 nM
PI3Kβ, IC50: 241.6 nM
PI3Kγ, IC50: 17.9 nM
PI3Kδ, IC50: 3.3 nM
             
FD223
PI3Kα, IC50: 51 nM
PI3Kβ, IC50: 29 nM
PI3Kγ, IC50: 37 nM
PI3Kδ, IC50: 1 nM
              98.68%
PI3Kγ inhibitor 2    
PI3Kγ, Ki: 4 nM
               
PI3Kdelta inhibitor 1      
PI3Kδ, IC50: 1.3 nM
             
LAS191954      
PI3Kδ, IC50: 2.6 nM
             
PI3K-IN-9      
PI3Kδ
             
CHMFL-PI3KD-317
PI3Kα, IC50: 62.6 nM
PI3Kβ, IC50: 284 nM
PI3Kγ, IC50: 202.7 nM
PI3Kδ, IC50: 6 nM
 
PIK3C2B, IC50: 882.3 nM
 
Vps34, IC50: 1801.7 nM
      98.04%
PI3Kγ inhibitor 4
PI3Kα, IC50: 300 nM
 
PI3Kγ, IC50: 40 nM
               
PI3K-IN-2
PI3Kα, IC50: 13 nM
PI3Kβ, IC50: 7.1 nM
PI3Kγ, IC50: 8.6 nM
PI3Kδ, IC50: 190 nM
             
PI3Kα-IN-6
PI3Kα
                   
PI3K-IN-37
PI3Kα, IC50: 6 nM
PI3Kβ, IC50: 8 nM
 
PI3Kδ, IC50: 4 nM
             
PI3K/mTOR Inhibitor-9
PI3Kα, IC50: 6.6 μM
PI3Kβ, IC50: >10 μM
PI3Kγ, IC50: 6.6 μM
PI3Kδ, IC50: 0.8 μM
             
PI3K-IN-33
PI3Kα, IC50: 11.73 μM
PI3Kβ, IC50: 6.09 μM
 
PI3Kδ, IC50: 11.18 μM
             
PI3K-IN-22
PI3Kα, IC50: 0.9 nM
                   
PI3Kδ-IN-10      
PI3Kδ, IC50: 2 nM
             
SN32976
PI3Kα, IC50: 15.1 nM
PI3Kβ, IC50: 461 nM
PI3Kγ, IC50: 110 nM
PI3Kδ, IC50: 134 nM
             
ATM Inhibitor-3                
PI3K
   
PI3Kδ-IN-11      
PI3Kδ, IC50: 27.5 nM
             
PI3K-IN-38
p110α, IC50: 0.541 μM
                   
NVP-CLR457
PI3Kα, IC50: 12 ± 1.5 nM
PI3Kβ, IC50: 8.3 ± 1.0 nM
PI3Kγ, IC50: 230 ± 31 nM
PI3Kδ, IC50: 8.3 ± 2.0 nM
             
TGX-155  
PI3Kβ
                 
PI3K-IN-34
PI3Kα, IC50: 8.43 μM
PI3Kβ, IC50: 15.84 μM
 
PI3Kδ, IC50: 30.62 μM
             
ATM Inhibitor-4                
PI3K
   
PI3K/HDAC-IN-2
PI3Kα, IC50: 226 nM
PI3Kβ, IC50: 279 nM
PI3Kγ, IC50: 467 nM
PI3Kδ, IC50: 29 nM
             
PI3K/mTOR Inhibitor-3                
PI3K
   
PI3Kα-IN-5
PI3Kα, IC50: 0.7 nM
                   
WYE-687 dihydrochloride
PI3K alpha, IC50: 81 nM
 
PI3K gamma, IC50: 3.11 μM
                ≥98.0%
PP30    
p110γ, IC50: 0.68 μM
p110δ, IC50: 0.99 μM
             
PI3Kα-IN-13
PI3Kα
                   
CHMFL-PI4K-127
PI3Kα, IC50: 191 ± 36 nM
PI3Kβ, IC50: 392 ± 27 nM
PI3Kγ, IC50: 324 ± 19 nM
PI3Kδ, IC50: 104 ± 3 nM
     
Vps34, IC50: 681 ± 25 nM
     
GSK2292767      
PI3Kδ, pIC50: 10.1
             
PI3K/mTOR Inhibitor-12
PI3Kα, IC50: 0.06 nM
                   
Umbralisib R-enantiomer      
PI3Kδ
              99.52%
COX-2/PI3K-IN-2                
PI3K, IC50: 2.78 nM
   
MEK/PI3K-IN-2
PI3Kα, IC50: 107 ± 21 nM
PI3Kβ, IC50: 3880 ± 725 nM
PI3Kγ, IC50: 2567 ± 364 nM
PI3Kδ, IC50: 137 ± 7 nM
             
ATR-IN-15                
PI3K, IC50: 5131 nM
   
PH14
PI3Kα, IC50: 20.3 nM
                   
PI3Kδ/γ-IN-3    
PI3Kγ, IC50: 16 nM
PI3Kδ, IC50: 1 nM
             
FD274
PI3Kα, IC50: 0.65 nM
PI3Kβ, IC50: 1.57 nM
PI3Kγ, IC50: 0.42 nM
PI3Kδ, IC50: 0.65 nM
             
PI3Kα-IN-7
PI3Kα
PI3Kβ
                 
PI3K-IN-35
PI3Kα, IC50: 13.98 μM
PI3Kβ, IC50: 7.22 μM
 
PI3Kδ, IC50: 10.94 μM
             
α-Linolenic acid (Standard)                
PI3K
   
PI3Kα-IN-11
PI3Kα
                   
PI3Kγ inhibitor 7
PI3Kα, IC50: 4768 nM
PI3Kβ, IC50: 878.1 nM
PI3Kγ, IC50: 3.42 nM
PI3Kδ, IC50: 355.2 nM
             
MEK/PI3K-IN-1
PI3Kα, IC50: 130 ± 13 nM
PI3Kβ, IC50: 1537 ± 188 nM
PI3Kγ, IC50: 2745 ± 485 nM
PI3Kδ, IC50: 236 ± 29 nM
             
PI3K/mTOR Inhibitor-8
PI3Kα, IC50: 0.46 nM
                   
Flupentixol
PI3Kα, IC50: 127 nM
                   
IHMT-PI3K-455
PI3Kα, IC50: 6.717 μM
PI3Kβ, IC50: 42.04 nM
PI3Kγ, IC50: 7.1 nM
PI3Kδ, IC50: 0.57 nM
             
Isorhamnetin (Standard)                
PI3-K
   
PI3Kδ-IN-12
PI3Kα, pKi: 6.7
PI3Kβ, pKi: 6.4
PI3Kγ, pKi: 6.5
PI3Kδ, pIC50: 5.8
PI3Kδ, pKi: 8.0
             
PIK-75
p110α, IC50: 5.8 nM
p110β, IC50: 1.3 μM
p110γ, IC50: 76 nM
p110δ, IC50: 510 nM
PI3KC2α, IC50: 10 μM
PI3KC2β, IC50: 1 μM
 
hsVPS34, IC50: 2.6 μM
     
PI3K/mTOR Inhibitor-14                
PI3K, IC50: 171.4 nM
   
PI3Kδ-IN-18      
PI3Kδ, IC50: 0.1 nM
             
PI3Kα-IN-14
PI3Kα, IC50: 0.14 nM
PI3Kβ, IC50: 25.89 nM
PI3Kγ, IC50: 2.45 nM
PI3Kδ, IC50: 5.69 nM
             
CXJ-2                
PI3K
   
COX-2/PI3K-IN-1                
PI3K, IC50: 1.14 nM
   
PI3Kδ/γ-IN-2    
PI3Kγ, IC50: 4.3 nM
PI3Kδ, IC50: 1 nM
             
PI3K-IN-10                
PI3K
   
PI3Kα-IN-8
PI3Kα, IC50: 0.012 μM
PI3Kβ, IC50: 0.21 μM
PI3Kγ, IC50: 0.18 μM
PI3Kδ, IC50: 0.11 μM
             
PI3K/VEGFR2-IN-1                
PI3K, IC50: 2.21 μM
   
Topoisomerase I/II inhibitor 3                
PI3K
   
mTOR inhibitor-13
PI3Kα, IC50: 119 nM
                   
PI3Kγ inhibitor 1
PI3Kα, IC50: 10 μM
PI3Kβ, IC50: 10 μM
PI3Kγ, IC50: 100 nM
PI3Kδ, IC50: 100 nM
             
CAL-130 Racemate      
PI3Kδ
             
PI3Kδ-IN-15
p110α, IC50: 152 nM
p110β, IC50: 145 nM
p110γ, IC50: 15.3 nM
p110δ, IC50: 0.5 nM
             
ON 146040
PI3Kα, IC50: 14 nM
PI3Kβ, IC50: 3 μM
PI3Kγ, IC50: 1 μM
PI3Kδ, IC50: 20 nM
             
CAL-130
p110α, IC50: 115 nM
p110β, IC50: 56 nM
p110γ, IC50: 6.1 nM
p110δ, IC50: 1.3 nM
             
PI3kδ inhibitor 1      
PI3Kδ, IC50: 3.8 nM
             
PI3Kα/mTOR-IN-1
PI3Kα, Ki: 12.5 nM
PI3Kα, IC50: 7 nM (Cell Assay)