MMP-3
MMP-3 (stromelysin-1) is a broadly reactive matrixin that digests proteoglycans, fibronectin, laminin and type IV collagen, and, most importantly, acts as a physiological activator of other zymogens including pro-MMP-1, pro-MMP-8 and pro-MMP-9, thereby initiating proteolytic cascades in inflamed tissue. It is produced mainly by fibroblasts, chondrocytes and synovial cells and is strongly induced by IL-1 and TNF-alpha. The promoter 5A/6A polymorphism influences transcriptional output and has been linked to coronary artery disease and aneurysm formation. Because of its central position in cartilage catabolism, MMP-3 is regarded as both a marker and a candidate target in rheumatoid arthritis and osteoarthritis research.
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MMP-3 Recombinant Proteins (2)
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Inhibitors & Agonists (58)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
