Cytidine Deaminase
CDA
Cytidine deaminase (CDA) is an enzyme involved in pyrimidine salvaging, it catalyzes the irreversible hydrolytic deamination of Cytidine and deoxycytidine to Uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. The recycling activity of CDA within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies, such as gemcitabine. Thus, CDA overexpression is often associated with lower systemic, chemotherapy-related, adverse effects but also with resistance to treatment. Considering the increasing interest of CDA in cancer chemoresistance, the aims of this review are to describe CDA structure, regulation of expression, and activity, and to report the therapeutic strategies based on CDA expression that recently emerged for tumor treatment.
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Cytidine Deaminase Related Products (13)
Related Products (13)
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Zebularine
0 ImagesZebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a Ki of 0.95 μM.
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Tetrahydrouridine
0 ImagesSynonyms: THU; NSC-112907
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Cedazuridine
0 ImagesSynonyms: E7727
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Ibacitabine
0 ImagesSynonyms: 5-Iodo-2'-deoxycytidineIbacitabine (5-Iodo-2'-deoxycytidine) is a nucleoside analog that serves as a substrate for cytidine deaminase, with antiviral and antitumor activities. Ibacitabine is preferentially phosphorylated and activated by kinases specifically induced by herpesviruses, thereby being converted into its active form (IdUTP) and incorporated into viral DNA in infected cells. Ibacitabine can be used in the research of herpes simplex virus infection and herpetic keratitis.
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5'-Deoxy-5-fluorocytidine
0 ImagesSynonyms: 5-Fluoro-5'-deoxycytidine5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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5'-Deoxy-5-fluorocytidine (Standard)
0 ImagesSynonyms: 5-Fluoro-5'-deoxycytidine (Standard)5'-Deoxy-5-fluorocytidine (Standard) is the analytical standard of 5'-Deoxy-5-fluorocytidine (HY-W009538). This product is intended for research and analytical applications. 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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Tetrahydrouridine-d3
0 ImagesCat. No.: HY-15345ASSynonyms: THU-d3; NSC-112907-d3
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5'-Deoxy-5-fluorocytidine-13C5
0 ImagesCat. No.: HY-W009538S1Synonyms: 5-Fluoro-5'-deoxycytidine-13C55'-Deoxy-5-fluorocytidine-13C5 is the 13C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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Cedazuridine hydrochloride
0 ImagesCat. No.: HY-109081ASynonyms: E7727 hydrochloride
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5'-Deoxy-5-fluorocytidine-d3
0 ImagesCat. No.: HY-W009538SSynonyms: 5-Fluoro-5'-deoxycytidine-d35'-Deoxy-5-fluorocytidine-d3 is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
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Tetrahydrouridine (Standard)
0 ImagesCat. No.: HY-15345ARCAS No.: 18771-50-1Synonyms: THU (Standard); NSC-112907 (Standard)Tetrahydrouridine (Standard) is the analytical standard of Tetrahydrouridine. This product is intended for research and analytical applications. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
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Cedazuridine (Standard)
0 ImagesSynonyms: E7727 (Standard)Cedazuridine (Standard) is the analytical standard of Cedazuridine. This product is intended for research and analytical applications. Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research.
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