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Cedazuridine hydrochloride  (Synonyms: E7727 hydrochloride)

Cat. No.: HY-109081A
Handling Instructions

Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research.

For research use only. We do not sell to patients.

Cedazuridine hydrochloride Chemical Structure

Cedazuridine hydrochloride Chemical Structure

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Description

Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research[1].

IC50 & Target

IC50: 0.4 μM (CDA)[1]

In Vitro

Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
Dosage: 3 mg/kg
Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
Animal Model: NSGS male mice[2]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.
Clinical Trial
Molecular Weight

304.68

Formula

C9H15ClF2N2O5

SMILES

[H]Cl.FC1([C@H](N(CC[C@@H](O)N2)C2=O)O[C@H](CO)[C@H]1O)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Cedazuridine hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cedazuridine hydrochloride
Cat. No.:
HY-109081A
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