1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme of serotonin (5-hydroxytryptamine) synthesis. TPH catalyzes the rate-limiting step in 5-HT biosynthesis. TPH exists as two isoforms, TPH1 and TPH2, which are encoded on two independent genes. TPH1 is mainly synthesized by enterochromaffin cells in the gut, whereas TPH2 is produced by serotonergic neurons in the central nervous system and by enteric neurons in the gut. TPH1 is the primary form and expresses earlier in neural development.

Tryptophan Hydroxylase Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-B1368
    Fenclonine Inhibitor
    Fenclonine is a potent and irreversible inhibitor of tryptophan (Trp) hydroxylase, the rate-limiting enzyme in serotonin biosynthesis.
  • HY-13055B
    Telotristat Inhibitor 98.91%
    Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM.
  • HY-13055A
    Telotristat ethyl Inhibitor 99.68%
    Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-15849A
    LP-533401 hydrochloride Inhibitor 98.09%
    LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
  • HY-13055
    Telotristat etiprate Inhibitor
    Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-101456
    PCPA methyl ester hydrochloride Inhibitor
    PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.
  • HY-19572
    ACT-678689 Inhibitor
    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
  • HY-13041
    LX-1031 Inhibitor 99.58%
    LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
  • HY-23460
    p-Ethynylphenylalanine Inhibitor 98.25%
    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.
  • HY-15849
    LP-533401 Inhibitor ≥98.0%
    LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
  • HY-23460A
    p-Ethynylphenylalanine hydrochloride Inhibitor 99.42%
    p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM.
Isoform Specific Products

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