1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Tryptophan Hydroxylase

Tryptophan Hydroxylase

Tryptophan hydroxylase (TPH) is a rate-limiting enzyme of serotonin (5-hydroxytryptamine) synthesis. TPH catalyzes the rate-limiting step in 5-HT biosynthesis. TPH exists as two isoforms, TPH1 and TPH2, which are encoded on two independent genes. TPH1 is mainly synthesized by enterochromaffin cells in the gut, whereas TPH2 is produced by serotonergic neurons in the central nervous system and by enteric neurons in the gut. TPH1 is the primary form and expresses earlier in neural development.

Tryptophan Hydroxylase Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-13055B
    Telotristat Inhibitor 99.46%
    Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM.
  • HY-B1368
    Fenclonine Inhibitor 99.10%
    Fenclonine is a pharmaceutical intermediate.
  • HY-13055A
    Telotristat ethyl Inhibitor 99.68%
    Telotristat ethyl (LX1606) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-13041
    LX-1031 Inhibitor 99.55%
    LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
  • HY-13055
    Telotristat etiprate Inhibitor 99.77%
    Telotristat etiprate (LX1606 Hippurate) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-23460
    4-Ethynyl-L-phenylalanine Inhibitor
    4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
  • HY-19572
    ACT-678689 Inhibitor
    ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
  • HY-15849
    LP-533401 Inhibitor >98.0%
    LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
  • HY-15849A
    LP-533401 hydrochloride Inhibitor 98.09%
    LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
  • HY-101124
    Rodatristat ethyl Inhibitor
    Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).
  • HY-120083
    Rodatristat Inhibitor
    Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.
Isoform Specific Products

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