Tetrahydropapaverine hydrochloride

Name: Tetrahydropapaverine hydrochloride
Brand: MedChemExpress
SKU: HY-N0137
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0137 Purity: 99.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons.

For research use only. We do not sell to patients.

Tetrahydropapaverine hydrochloride Chemical Structure

CAS No. : 6429-04-5

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
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200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Tetrahydropapaverine hydrochloride:

(R)-Tetrahydropapaverine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons^[1]^[2].

Molecular Weight

379.88

Formula

C₂₀H₂₆ClNO₄

CAS No.

6429-04-5

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC2=C(C=C1OC)CCNC2CC3=CC=C(OC)C(OC)=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (263.24 mM)

DMSO : 50 mg/mL (131.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6324 mL	13.1621 mL	26.3241 mL
5 mM	0.5265 mL	2.6324 mL	5.2648 mL
10 mM	0.2632 mL	1.3162 mL	2.6324 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.53%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (251 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16. [Content Brief]

[2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.6324 mL	13.1621 mL	26.3241 mL	65.8103 mL
	5 mM	0.5265 mL	2.6324 mL	5.2648 mL	13.1621 mL
	10 mM	0.2632 mL	1.3162 mL	2.6324 mL	6.5810 mL
	15 mM	0.1755 mL	0.8775 mL	1.7549 mL	4.3874 mL
	20 mM	0.1316 mL	0.6581 mL	1.3162 mL	3.2905 mL
	25 mM	0.1053 mL	0.5265 mL	1.0530 mL	2.6324 mL
	30 mM	0.0877 mL	0.4387 mL	0.8775 mL	2.1937 mL
	40 mM	0.0658 mL	0.3291 mL	0.6581 mL	1.6453 mL
	50 mM	0.0526 mL	0.2632 mL	0.5265 mL	1.3162 mL
	60 mM	0.0439 mL	0.2194 mL	0.4387 mL	1.0968 mL
	80 mM	0.0329 mL	0.1645 mL	0.3291 mL	0.8226 mL
	100 mM	0.0263 mL	0.1316 mL	0.2632 mL	0.6581 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.