1. Anti-infection
  2. Bacterial

Gatifloxacin (Synonyms: BMS 206584-01; PD 135432; AM-1155)

Cat. No.: HY-10581 Purity: 98.07%
Handling Instructions

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

For research use only. We do not sell to patients.

Gatifloxacin Chemical Structure

Gatifloxacin Chemical Structure

CAS No. : 112811-59-3

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1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Target: Antibacterial Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Gatifloxacin had activity equal to that of tosufloxacin and activity more potent than those of norfloxacin, ofloxacin, ciprofloxacin, and sparfloxacin against the second-step mutants (grlA gyrA; gatifloxacin MIC range, 1.56 to 3.13 microg/ml) and had the most potent activity against the third-step mutants (grlA gyrA grlA; gatifloxacin MIC range, 1.56 to 6.25 microg/ml), suggesting that gatifloxacin possesses the most potent inhibitory activity against singly mutated topo IV and singly mutated DNA gyrase among the quinolones tested [1]. Ophthalmic gatifloxacin 0.3% is at least as effective as ciprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than ciprofloxacin. Trends favored gatifloxacin in fluorescein retention scores [2]. Clinical indications: Bacterial infection FDA Approved Date: Toxicity: Hepatotoxicity; Acute pancreatitis [3]; Torsades de pointes [4]

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (2.66 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6639 mL 13.3195 mL 26.6390 mL
5 mM 0.5328 mL 2.6639 mL 5.3278 mL
10 mM 0.2664 mL 1.3319 mL 2.6639 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

375.39

Formula

C₁₉H₂₂FN₃O₄

CAS No.

112811-59-3

SMILES

CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Gatifloxacin
Cat. No.:
HY-10581
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Gatifloxacin

Cat. No.: HY-10581