1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Topoisomerase
    Antibiotic
  3. Gatifloxacin mesylate

Gatifloxacin mesylate (Synonyms: AM-1155 mesylate; BMS-206584 mesylate; PD135432 mesylate)

Cat. No.: HY-10581B
Handling Instructions

Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin mesylate can be used to treat bacterial conjunctivitis in vivo.

For research use only. We do not sell to patients.

Gatifloxacin mesylate Chemical Structure

Gatifloxacin mesylate Chemical Structure

CAS No. : 316819-28-0

Size Price Stock
500 mg USD 50 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Other In-stock Forms of Gatifloxacin mesylate:

Other Forms of Gatifloxacin mesylate:

Top Publications Citing Use of Products

Publications Citing Use of MCE Gatifloxacin mesylate

View All Topoisomerase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin mesylate can be used to treat bacterial conjunctivitis in vivo.

IC50 & Target

Topoisomerase II

36.7 μM (IC50)

In Vitro

Gatifloxacin mesylate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC50 values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively[1].
Gatifloxacin mesylate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively[1].
Gatifloxacin mesylate exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin mesylate displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935[2].
Gatifloxacin mesylate has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml)[2].
Gatifloxacin mesylate (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin mesylate, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Gatifloxacin mesylate (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice with Nocardia brasiliensis in the right hind footpad.
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 3 times a day; 30 days
Result: Reduced the production of lesions in mice.
Clinical Trial
Molecular Weight

471.50

Formula

C₂₀H₂₆FN₃O₇S

CAS No.

316819-28-0

SMILES

CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1.O=S(C)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GatifloxacinAM-1155BMS-206584PD135432AM1155AM 1155BMS206584BMS 206584PD 135432PD-135432BacterialTopoisomeraseAntibioticE. coliPseudomonas aeruginosaMicrococcus luteusS. aureushypoglycemiahyperglycemiadiabeticactinomycetomaN. brasiliensisbacterialconjunctivitisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Gatifloxacin mesylate
Cat. No.:
HY-10581B
Quantity:
MCE Japan Authorized Agent: