Signaling Pathway

nAChR

nAChR

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Nicotinic acetylcholine receptors, or nAChRs, are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels and do not use second messengers. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor—the muscarinic acetylcholine receptor (mAChR)—the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR Inhibitors & Modulators (29)

Product Name Catalog No. Brief Description
A-867744

HY-12149

A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X.

Acetylcholine chloride

HY-B0282

Acetylcholine is a neurotransmitter that can induce the opening of calcium channels.

Adiphenine hydrochloride

HY-B0379A

Adiphenine HCl is a nicotinic receptor inhibitor, used as an antispasmodic drug.

Aniracetam

HY-10932

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.

Atracurium besylate

HY-B0292A

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.

Carbamoylcholine chloride

HY-B1208

Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.

Catharanthine

HY-N0252

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.

Cisatracurium besylate

HY-13596

Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.

Decamethonium Bromide

HY-B0570

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Dinotefuran

HY-B0827

Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.

EVP-6124

HY-15430

EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.

EVP-6124 hydrochloride

HY-15430A

EVP-6124 Hcl is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

GTS-21 dihydrochloride

HY-14564A

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.

Hexamethonium Bromide

HY-B0569

Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.

L-Nicotine

HY-B0638

L-Nicotine is the prototype of nicotinic acetylcholine receptor agonists; natural isomer.

Lobeline hydrochloride

HY-B0979

Lobeline  hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

Methscopolamine bromide

HY-B0344

Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker.

Monepantel

HY-14774

Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

Pancuronium dibromide

HY-B0429

Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.

PNU-120596

HY-12152

PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.