1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR Related Products (42):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987 Agonist 99.70%
    PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-N2332A
    Methyllycaconitine citrate Antagonist >98.0%
    Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR).
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
  • HY-14564A
    GTS-21 dihydrochloride Agonist 99.76%
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
  • HY-W008350
    (+)-Sparteine Inhibitor >98.0%
    (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
  • HY-114269
    (-)-(S)-B-973B Agonist 99.93%
    (-)-(S)-B-973B is a potent allosteric agonism and positive allosteric modulation (ago-PAM) for α7 nAChR, with antinociceptive activity.
  • HY-N0175
    Cytisinicline Agonist >98.0%
    Cytisinicline (Cytisine) is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation.
  • HY-14774
    Monepantel Agonist 99.43%
    Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
  • HY-B0569
    Hexamethonium Bromide Antagonist >98.0%
    Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.
  • HY-14316A
    Tebanicline hydrochloride Modulator 98.00%
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.
  • HY-11013
    ZSET1446 Agonist 98.03%
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
  • HY-15430A
    Encenicline hydrochloride Agonist 98.20%
    Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
  • HY-B0429
    Pancuronium dibromide Antagonist >98.0%
    Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.
  • HY-17555
    Meclofenoxate hydrochloride Inhibitor
    Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
  • HY-12152
    PNU-120596 Agonist 98.15%
    PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.
  • HY-107675
    Desformylflustrabromine hydrochloride Agonist 99.77%
    Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
  • HY-B0979
    Lobeline hydrochloride Agonist 99.97%
    Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
  • HY-10019
    Varenicline Agonist 99.98%
    Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  • HY-B1532
    Anabasine Agonist 98.71%
    Anabasine is a nicotinic receptor agonist.
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