PHA-543613 hydrochloride
PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. PHA-543613 hydrochloride affects sensory gating and memory in an in vivo model of schizophrenia.
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- CAS No.: 1586767-92-1
- Formule: C15H18ClN3O2
- Masse moléculaire:307.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Chemical Information
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CAS No. 1586767-92-1
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Masse moléculaire 307.78
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Formule C15H18ClN3O2
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SMILES
O=C(C1=CC2=C(OC=C2)C=N1)N[C@H]3CN4CCC3CC4.[H]Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Faghih R, et al. Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2008 Feb 28;51(4):701-12. [Content Brief]
[2]. Wishka DG, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PHA-543613 hydrochloride Related Classifications
HY-105670A Related Classifications
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