Cat. No.: HY-L136

Coagulation and Anti-coagulation Compound Library

85 Cited Publications

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Based on 85 publication(s) in Google Scholar

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 1,502 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (85)
Documentation
Composition

Description & Advantages

• A unique collection of 1,502 Coagulation and Anti-coagulation related compounds for high throughput screening (HTS) and high content screening (HCS).

• A useful tool to screen new inhibitors of coagulation and anti-coagulation.

• Target diverse, medicinally active and cell permeable.

• Bioactivity and safety confirmed by preclinical research and clinical trials.

• More detailed compound information with structure, IC50, and other chemical & biological data.

• High purity and quality validated by NMR and LC/MS.

Product Details

Formulation

A collection of 1,502 Coagulation and Anti-coagulation related compounds supplied as pre-dissolved Solutions or Solid

Solution: 1,453 compounds supplied in 10 mM solution, 40 compounds supplied in 2 mM solution, 9 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice