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Trk receptors family is composed of three receptor tyrosine kinases (RTKs): TrkA, TrkB and TrkC, also called neurotrophic tyrosine receptor kinases (NTRK1-NTRK3) that function as high affinity signaling receptors for various neurotrophins, including nerve
High affinity nerve growth factor receptor;
Trk-A; NTRK1; MTC; TRK
Human
HEK293
Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.
The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-hFc, C-His, C-10*His labeled tag. The total length of TrkB Protein, Human (HEK293, His-Fc) is 399 a.a., with molecular weight of 95-130 kDa.
TrkC Protein, a receptor tyrosine kinase, crucially contributes to nervous system and potential heart development. Upon NTF3/neurotrophin-3 binding, TrkC undergoes autophosphorylation, activating pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways regulate cell survival and differentiation, emphasizing TrkC's pivotal role in essential cellular processes during development. TrkC Protein, Human (HEK293, His) is the recombinant human-derived TrkC protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkC Protein, Human (HEK293, His) is 428 a.a., with molecular weight of 80-90 kDa.
TrkA Protein, Human (HEK293) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death.
High affinity nerve growth factor receptor;
Trk-A; NTRK1; MTC; TRK
Rat
HEK293
The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, His) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rat (HEK293, His) is 386 a.a., with molecular weight of ~70-95 kDa.
TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, His) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Canine (HEK293, His) is 399 a.a., with molecular weight of ~60-78 kDa.
TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, His) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Rat (HEK293, His) is 398 a.a., with molecular weight of ~67 kDa.
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
Mouse
HEK293
TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-His, C-8*His labeled tag. The total length of TrkA Protein, Mouse (HEK293, His) is 387 a.a., with molecular weight of ~55-125 kDa.
TrkB, a pivotal receptor tyrosine kinase, orchestrates diverse neuronal processes in the central and peripheral nervous systems. Serving as a receptor for BDNF and NTF4, it modulates survival through NTF3. Upon ligand binding, TrkB undergoes activation, initiating downstream cascades. It recruits effectors like SHC1, FRS2, SH2B1, SH2B2, and PLCG1, regulating pathways for differentiation, growth, survival, and synaptic plasticity. TrkB's role in learning involves short-term synaptic function, long-term potentiation, and PLCG1-mediated suppression of anoikis. Additionally, it contributes to neurotrophin-dependent calcium signaling in glial cells. TrkB Protein, Rat (HEK293, C-His) is the recombinant rat-derived TrkB protein, expressed by HEK293, with C-6*His labeled tag. The total length of TrkB Protein, Rat (HEK293, C-His) is 398 a.a., with molecular weight of ~62-85 kDa.
The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TrkB Protein, Human (HEK293, His) is 399 a.a., with molecular weight of 60-105 kDa.
TrkC Protein, a receptor tyrosine kinase, is vital in nervous system and potential heart development. Upon binding its ligand NTF3/neurotrophin-3, TrkC undergoes autophosphorylation, activating key signaling pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways intricately govern cell survival and differentiation, underscoring TrkC's pivotal role in orchestrating fundamental processes during development. TrkC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TrkC Protein, Mouse (HEK293, His) is 398 a.a., with molecular weight of 80-110 kDa.
TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (398a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (398a.a, HEK293, His) is 398 a.a., with molecular weight of 60-90 kDa.
High affinity nerve growth factor receptor;
Trk-A; NTRK1; MTC; TRK
Human
HEK293
TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. TrkA Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkA protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkA Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of 85-95 kDa.
TrkC Protein, a receptor tyrosine kinase, crucially contributes to nervous system and potential heart development. Upon NTF3/neurotrophin-3 binding, TrkC undergoes autophosphorylation, activating pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways regulate cell survival and differentiation, emphasizing TrkC's pivotal role in essential cellular processes during development. TrkC Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkC protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkC Protein, Human (HEK293, His-Fc) is 428 a.a., with molecular weight of 110-120 kDa.
TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (429a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (429a.a, HEK293, His) is 429 a.a., with molecular weight of 75-85 kDa.
High affinity nerve growth factor receptor;
Trk-A; NTRK1; MTC; TRK
Canine
HEK293
TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, His) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Canine (HEK293, His) is 126 a.a., with molecular weight of 27-33 kDa.
High affinity nerve growth factor receptor;
Trk-A; NTRK1; MTC; TRK
Rat
HEK293
The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Rat (HEK293, Fc) is 418 a.a., with molecular weight of 92-102 kDa.
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
Canine
HEK293
TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of TrkA Protein, Canine (HEK293, Fc) is 126 a.a., with molecular weight of 55-61 kDa.
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
Mouse
HEK293
TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Mouse (HEK293, Fc) is 420 a.a., with molecular weight of ~116 kDa.
TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkB Protein, Rat (HEK293, Fc) is 429 a.a., with molecular weight of ~120 kDa.
