1. Recombinant Proteins
  2. Receptor Proteins
  3. Enzyme-linked receptors
  4. Trk receptors

Trk receptors family is composed of three receptor tyrosine kinases (RTKs): TrkA, TrkB and TrkC, also called neurotrophic tyrosine receptor kinases (NTRK1-NTRK3) that function as high affinity signaling receptors for various neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or neurotrophin-4 (NTF-4). Trk receptors have an extracellular ligand-binding domain, a single transmembrane domain and a cytoplasmic part with tyrosine kinase catalytic activity. TrkA specifically binds to NGF, while TrkB interacts with both BDNF and NT-4. TrkC is the specific receptor for NT-3. Neurotrophin signaling through these receptors mediate cell survival, proliferation, the fate of neural precursors, axon and dendrite growth and patterning, and the expression and activity of functionally important proteins, such as ion channels and neurotransmitter receptors. Interestingly, p75 neurotrophin receptor (p75NTR) is coexpressed with Trk receptors in long-range projection neurons, in which it facilitates neurotrophin binding to Trk and enhances Trk activity. Unlike Trk receptors, p75NTR is a pan-neurotrophin receptor that binds all the neurotrophins. (Targeting Trk Receptor )

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity