TrkC Protein, Human (HEK293, His)

TrkC Protein, a receptor tyrosine kinase, crucially contributes to nervous system and potential heart development. Upon NTF3/neurotrophin-3 binding, TrkC undergoes autophosphorylation, activating pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways regulate cell survival and differentiation, emphasizing TrkC's pivotal role in essential cellular processes during development. TrkC Protein, Human (HEK293, His) is the recombinant human-derived TrkC protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkC Protein, Human (HEK293, His) is 428 a.a., with molecular weight of 80-90 kDa.

TrkC Protein, a receptor tyrosine kinase, plays a crucial role in nervous system and potential heart development. Upon binding to its ligand NTF3/neurotrophin-3, TrkC undergoes autophosphorylation, initiating various signaling pathways such as the phosphatidylinositol 3-kinase/AKT and the MAPK pathways. These pathways are instrumental in regulating cell survival and differentiation, highlighting the pivotal role of TrkC in orchestrating essential cellular processes during development.

Imobilized human Trkc-His at 10 μg/mL (100 μl/well )can bind biotinylated human NT3, The EC₅₀ of biotinylated human NT3 is 0.03-0.07 μg/mL.

Human

HEK293

C-His

Q16288 (M1-D428)

4916  [NCBI]

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of Lyophilized from sterile PBS, pH 7.4, 5% Trehalose.5% Manitol, 0.01% Tween-80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.