2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Energy Metabolism

Energy Metabolism

Disorders of energy metabolism are characterized by dysregulation in the processing and utilization of energy substrates, impacting essential physiological processes such as enzyme synthesis and hormonal control of energy homeostasis. These disturbances are closely linked to metabolic conditions including type 2 diabetes mellitus and polycystic ovary syndrome, with affected tissues primarily involving skeletal muscle and lung.

 

Energy Metabolism (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112537
    D-Glucose 6-phosphate 56-73-5 99.90%
    D-Glucose 6-phosphate is a key central node metabolite in glucose metabolism. It serves as the initiating metabolite for glycolysis and the pentose phosphate pathway, as well as a substrate for glycogen synthesis. D-Glucose 6-phosphate acts as a metabolic stress signal, which activates the mTOR pathway to promote protein synthesis, especially when phosphoglucose isomerase (PGI) is inhibited, thereby participating in cardiac remodeling processes. D-Glucose 6-phosphate can be used in research related to non-insulin-dependent diabetes mellitus and heart failure.
    D-Glucose 6-phosphate
  • HY-B0486
    Lonidamine 50264-69-2 99.91%
    Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis.
    Lonidamine
  • HY-175128
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate sodium
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate (8-AET-GTP) is a GTP (HY-113225) derivative. GTP is the energy substrate for protein synthesis and gluconeogenesis.
    8-(2-Aminoethylthio)guanosine-5'-O-triphosphate sodium
  • HY-N0886R
    Aloin B (Standard) 28371-16-6
    Aloin B (Isobarbaloin) (Standard) is the analytical standard of Aloin B. This product is intended for research and analytical applications. Aloin B is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation.
    Aloin B (Standard)
  • HY-W782567
    5-Amino-6-(5-phospho-D-ribitylamino)uracil 71491-01-5
    5-Amino-6-(5-phospho-D-ribitylamino)uracil is a substance that enhances oxidative phosphorylation or mitochondrial respiration. 5-Amino-6-(5-phospho-D-ribitylamino)uracil can enhance mitochondrial oxidative function. 5-Amino-6-(5-phospho-D-ribitylamino)uracil can be used in the research of cancer.
    5-Amino-6-(5-phospho-D-ribitylamino)uracil