Sodium citrate dihydrate, meets USP testing specifications
Based on 13 publication(s) in Google Scholar
Sodium citrate (Trisodium citrate) dihydrate, meets USP testing specifications is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 6132-04-3
- Formula: C6H9Na3O9
- Molecular Weight:294.10
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0322
Cholesterol (from animal)
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HY-112764
mPEG2000-DMG
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HY-N1428A
Citric acid monohydrate
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HY-B1610
Sodium citrate dihydrate
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HY-W040193
DSPC
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HY-B1610I
Sodium citrate dihydrate, for molecular biology
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HY-N1428
Citric acid
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HY-B1779
Sucrose
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HY-B1610ER
Sodium citrate dihydrate, meets USP testing specifications (Standard)
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HY-B1610H
Sodium citrate dihydrate, United States Pharmacopeia (USP) Reference Standard
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HY-B1610R
Sodium citrate dihydrate (Standard)
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HY-D0857
HEPES
Publications Citing Use of MedChemExpress (MCE) Sodium citrate dihydrate, meets USP testing specifications
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cancer. 2025 Oct 2;24(1):238. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102621. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Food Res Int. 2026 Feb 6.
- Regen Biomater. 2024 Aug 22:11:rbae098. [Abstract]
- Life Sci. 2024 Jun 15:347:122682. [Abstract]
- BMC Complement Med Ther. 2026 Apr 2;26(1):177. [Abstract]
- Insect Biochem Mol Biol. 2023 Jun:157:103958. [Abstract]
- Bone. 2025 Apr:193:117411. [Abstract]
- J Sep Sci. 2025 Nov;48(11):e70312. [Abstract]
- New J Chem. 03 Aug 2022.
Biological Activity
Sodium citrate dihydrate (100 μM) can enhance the inhibition effect of Rosemary acid (RA) on Vibrio bacterial[1].
Sodium citrate dihydrate (5-20 mM, 24-48 h) induces apoptosis of human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC-803
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Concentration:1.25, 2.5, 5, 10,15, 20, 30, 40, 60 mM
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Incubation Time:24, 48 h
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Result:Decreased cell viability in a dose-and time-dependent manner.
The IC50 value is 10.08 mM after 48 h.
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Cell Line:MGC-803
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Concentration:5, 10, 20 mM
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Incubation Time:24 h
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Result:Decreased the mRNA and protein expressions of anti-apoptotic Bcl-2 and Survivin.
Increased the mRNA and protein expression level of proapoptotic Bax, caspase-3 and Cyt-c.
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Cell Line:MGC-803
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Concentration:5, 10, 20 mM
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Incubation Time:24, 48 h
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Result:Induced cell apoptosis in a dose-and time-dependent manner.
Increased the G2/M phase arrest.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adenine-Induced Chronic Renal Failure Rat Model[3]
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Dosage:216, 746 mg/kg
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Administration:i.g.
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Result:Decreased the expression of renal fibrosis-related proteins TGF-β1 and CIV.
Decreased the expression of PERK, ATF6 and CHOP.
Chemical Information
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CAS No. 6132-04-3
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Appearance Solid
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Molecular Weight 294.10
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Formula C6H9Na3O9
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Color White to off-white
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SMILES
O=C(CC(C(O[Na])=O)(O)CC(O[Na])=O)O[Na].O.O
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Synonyms
Trisodium citrate dihydrate, meets USP testing specifications
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cancer
Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization. [Abstract]2025 Oct 2;24(1):238. PMID: 41039575 -
Cell Rep Med
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer. [Abstract]2026 Feb 17;7(2):102621. PMID: 41707647 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
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Regen Biomater
Polyzwitterion-grafted decellularized bovine intercostal arteries as new substitutes of small-diameter arteries for vascular regeneration. [Abstract]2024 Aug 22:11:rbae098. PMID: 39224131 -
Life Sci
Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]2024 Jun 15:347:122682. PMID: 38702025 -
BMC Complement Med Ther
Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. [Abstract]2026 Apr 2;26(1):177. PMID: 41923057 -
Insect Biochem Mol Biol
Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast. [Abstract]2023 Jun:157:103958. PMID: 37182814 -
Bone
The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS. [Abstract]2025 Apr:193:117411. PMID: 39884488 -
J Sep Sci
Cell Metabolomics Reveals the Hepatotoxic Mechanism of Copper in Normal Rat Liver Cells Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. [Abstract]2025 Nov;48(11):e70312. PMID: 41172059 -
Solvent & Solubility
H2O : 125 mg/mL (425.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Lu P, et al. Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake. Int J Mol Sci. 2021 Dec 1;22(23):13010. [Content Brief]
[2]. Guo X,et al. 3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway. Biochem Biophys Res Commun. 2016 Jun 17;475(1):37-43. [Content Brief]
[3]. Ou Y, et al. Sodium Citrate Inhibits Endoplasmic Reticulum Stress in Rats with Adenine-Induced Chronic Renal Failure. Am J Nephrol. 2015;42(1):14-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4002 mL | 17.0010 mL | 34.0020 mL | 85.0051 mL |
| 5 mM | 0.6800 mL | 3.4002 mL | 6.8004 mL | 17.0010 mL | |
| 10 mM | 0.3400 mL | 1.7001 mL | 3.4002 mL | 8.5005 mL | |
| 15 mM | 0.2267 mL | 1.1334 mL | 2.2668 mL | 5.6670 mL | |
| 20 mM | 0.1700 mL | 0.8501 mL | 1.7001 mL | 4.2503 mL | |
| 25 mM | 0.1360 mL | 0.6800 mL | 1.3601 mL | 3.4002 mL | |
| 30 mM | 0.1133 mL | 0.5667 mL | 1.1334 mL | 2.8335 mL | |
| 40 mM | 0.0850 mL | 0.4250 mL | 0.8501 mL | 2.1251 mL | |
| 50 mM | 0.0680 mL | 0.3400 mL | 0.6800 mL | 1.7001 mL | |
| 60 mM | 0.0567 mL | 0.2834 mL | 0.5667 mL | 1.4168 mL | |
| 80 mM | 0.0425 mL | 0.2125 mL | 0.4250 mL | 1.0626 mL | |
| 100 mM | 0.0340 mL | 0.1700 mL | 0.3400 mL | 0.8501 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium citrate dihydrate, meets USP testing specifications Related Classifications
HY-B1610E Related Classifications
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