2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Energy Metabolism
  5. Glycolysis

Glycolysis

Glycolysis is a fundamental metabolic pathway that converts glucose into pyruvate, generating a net gain of 2 ATP molecules and 2 NADH molecules per glucose molecule. This process occurs in the cytoplasm of cells and does not require oxygen, making it anaerobic. It consists of ten enzymatic steps divided into two phases: the energy investment phase, where ATP is consumed to phosphorylate glucose, and the energy payoff phase, where ATP and NADH are produced. Glycolysis serves as a critical source of energy for cells under both aerobic and anaerobic conditions and provides intermediates for other metabolic pathways such as the pentose phosphate pathway and gluconeogenesis. Dysregulation of glycolysis is associated with various diseases, including cancer, where increased glycolytic activity supports rapid cell proliferation, and certain metabolic disorders affecting glucose metabolism.

References:

Glycolysis (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0486
    Lonidamine 50264-69-2 99.91%
    Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis.
    Lonidamine