1. Apoptosis
  2. c-Myc

c-Myc

c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

c-Myc Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-12702
    10058-F4 Inhibitor
    10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression.
  • HY-19735
    KJ Pyr 9 Inhibitor
    KJ Pyr 9 is a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kr?hnke pyridine library. The Kd of KJ-Pyr-9 for MYC in vitro is 6.5 (plusmn) 1.0 nM, as determined by backscattering interferometry.
  • HY-100015
    Mivebresib Inhibitor
    Mivebresib, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo.
  • HY-N0822
    Shikonin Inhibitor
    Shikonin is an inhibitor of TMEM16A chloride channel with IC50 value of 6.5 uM.
  • HY-100996
    10074-G5 Inhibitor
    10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.