1. Apoptosis
    Autophagy
  2. c-Myc
    Autophagy
  3. Mycro 3

Mycro 3 

Cat. No.: HY-100669 Purity: 99.33%
Handling Instructions

Mycro 3 is a potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer.

For research use only. We do not sell to patients.

Mycro 3 Chemical Structure

Mycro 3 Chemical Structure

CAS No. : 944547-46-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 223 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 192 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
25 mg USD 672 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Mycro 3 is a potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc[1]. Mycro 3 could be used for the research of pancreatic cancer[2].

IC50 & Target

Myc-MAX dimerization[1]

In Vitro

Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA[1]. Mycro 3 exhibits an excellent specificity with IC50s of 0.25 and 9.0 µM for cells with intact Myc alleles and Myc-null cells, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Moribund Pdx1-cre/KRAS* mice bearing pancreatic ductal adenocarcinoma (PDA)[2]
Dosage: 100 mg/kg
Administration: Oral administration; daily for two months
Result: Increased survival time.
Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.
Molecular Weight

526.88

Formula

C₂₄H₁₇ClF₂N₆O₄

CAS No.

944547-46-0

SMILES

O=C(C1=C(NC(C2=NN3C(C(F)(Cl)F)=CC(C4=CC=CO4)=NC3=C2)=O)N(C5=CC=CC=C5)N=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8980 mL 9.4898 mL 18.9797 mL
5 mM 0.3796 mL 1.8980 mL 3.7959 mL
10 mM 0.1898 mL 0.9490 mL 1.8980 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (4.74 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

Mycro 3Mycro3Mycro-3c-MycAutophagyMycMAXdimerizationpancreaticPancreaticductaladenocarcinomaPDAInhibitorinhibitorinhibit

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Mycro 3
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