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Results for "

Myc

" in MCE Product Catalog:

By Targets:	c-Myc (38) Akt (1) Antibiotic (1) Apoptosis (19) Autophagy (12) Bacterial (2) Bcl-2 Family (1) Casein Kinase (3) Caspase (3) CDK (8) DNA/RNA Synthesis (1) DYRK (1) Early 2 Factor (E2F) (1) Endogenous Metabolite (1) Epigenetic Reader Domain (19) Eukaryotic Initiation Factor (eIF) (10) Fatty Acid Synthase (FASN) (1) Fungal (1) FXR (1) GSK-3 (2) Histone Acetyltransferase (4) Histone Methyltransferase (3) JNK (1) KLF (1) MEK (2) NAMPT (2) Notch (1) p38 MAPK (3) PARP (1) Phosphatase (2) PPAR (1) PROTACs (4) Sirtuin (2) STAT (2) Topoisomerase (1) Wnt (2) β-catenin (3)
By Research Areas:	Cancer (100) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (5) Metabolic Disease (1)

By Targets:

c-Myc (38)

Akt (1)

Antibiotic (1)

Apoptosis (19)

Autophagy (12)

Bacterial (2)

Bcl-2 Family (1)

Casein Kinase (3)

Caspase (3)

CDK (8)

DNA/RNA Synthesis (1)

DYRK (1)

Early 2 Factor (E2F) (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (19)

Eukaryotic Initiation Factor (eIF) (10)

Fatty Acid Synthase (FASN) (1)

Fungal (1)

FXR (1)

GSK-3 (2)

Histone Acetyltransferase (4)

Histone Methyltransferase (3)

JNK (1)

KLF (1)

MEK (2)

NAMPT (2)

Notch (1)

p38 MAPK (3)

PARP (1)

Phosphatase (2)

PPAR (1)

PROTACs (4)

Sirtuin (2)

STAT (2)

Topoisomerase (1)

Wnt (2)

β-catenin (3)

By Research Areas:

Cancer (100)

Cardiovascular Disease (2)

Infection (6)

Inflammation/Immunology (5)

Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

MCE Kits

Natural
Products

145

Recombinant Proteins

Antibodies

Targets Recommended: c-Myc

Cat. No.	Product Name	Target	Research Areas

HY-141666

MYC-IN-2
c-Myc Cancer

MYC-IN-2 is a MYC protein-protein inhibitor. MYC-IN-2 can be used for the research of cancer.

MYC-IN-2	c-Myc	Cancer
MYC-IN-2 is a MYC protein-protein inhibitor. MYC-IN-2 can be used for the research of cancer.

HY-100669

Mycro 3	c-Myc Autophagy	Cancer
Mycro 3 is an orally active, potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer.

HY-125636

Mycro1	Others	Cancer
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation.

HY-126979

Mycro2	Others	Cancer
Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation.

HY-124675

MYCMI-6 NSC354961	c-Myc Apoptosis	Cancer
MYCMI-6 (NSC354961) is a potent and selective endogenous *MYC:MAX* protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a K_d of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC₅₀<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis.

HY-129600

MYCi361 NUCC-0196361	c-Myc	Cancer
MYCi361 (NUCC-0196361) is a *MYC* inhibitor with the K_d of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy.

HY-148836

*c-Myc* inhibitor 6**	c-Myc	Cancer Infection Cardiovascular Disease
c-Myc inhibitor 6 (compound A102) is a *c-Myc* inhibitor. c-Myc inhibitor 6 decreases cancer cell viability and degrades c-Myc protein. c-Myc inhibitor 6 can be used for the research of c-Myc imbalance, such as cancer, cardiovascular diseases, and viral infection.

HY-148838

*c-Myc* inhibitor 8**	c-Myc	Cancer
c-Myc inhibitor 8 (compound 56) is a *c-Myc* inhibitor. c-Myc inhibitor 8 effectively inhibits cell viability of a variety of cancer cells. c-Myc inhibitor 8 inhibits human prostate and lung cancer growth in mouse models. c-Myc inhibitor 8 can be used for cancer research.

HY-148837

*c-Myc* inhibitor 7**	c-Myc Casein Kinase	Cancer Infection Cardiovascular Disease
c-Myc inhibitor 7 is a *c-Myc* inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades *c-MYC, CK1α, GSPT1* and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection.

HY-148839

*c-Myc* inhibitor 9**	c-Myc	Cancer
c-Myc inhibitor 9 (compound 332) is a *c-Myc* inhibitor with an logEC₅₀ of ≥6. c-Myc inhibitor 9 inhibits tumor growth in nude mouse models. c-Myc inhibitor 9 can be used for cancer research.

HY-139885

c-Myc inhibitor 4
c-Myc Cancer

c-Myc inhibitor 4 is a potent, orally bioavailable c-MYC-reducing compound.

*c-Myc* inhibitor 4**	c-Myc	Cancer
c-Myc inhibitor 4 is a potent, orally bioavailable *c-MYC-reducing* compound.

HY-145843

*c-Myc* inhibitor 5**	c-Myc	Cancer
c-Myc inhibitor 5 (DA3) is a fluorescent, long chain-bridged bispurine that selectively targets the *c-MYC* G-quadruplex (K_D** of 16 μM). c-Myc inhibitor 5 shows inhibition on c-MYC expression rather than other G4-driven oncogenes.

HY-101280

LB-60-OF61
NAMPT Cancer

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.

LB-60-OF61	NAMPT	Cancer
LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.

HY-101280A

LB-60-OF61 hydrochloride	NAMPT	Cancer
LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.

HY-N10790

RA-V	Wnt c-Myc Notch	Cancer
RA-V is a cyclic hexapeptide. RA-V has activity against *Wnt, Myc* and Notch with IC₅₀** values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.

HY-134582

dCBP-1	PROTACs Epigenetic Reader Domain	Cancer
dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression.

HY-139330

MGH-CP1	Apoptosis	Cancer
MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC₅₀s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion.

HY-134761

EN4	c-Myc	Cancer
EN4 is a covalent ligand that targets cysteine 171 (C171) of *MYC. EN4 is selective for c-MYC* over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.

HY-133121

WDR5-IN-1	Histone Methyltransferase Apoptosis	Cancer
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a K_d of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC₅₀ of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines.

HY-12702

10058-F4
c-Myc Autophagy Cancer

10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

10058-F4	c-Myc Autophagy	Cancer
10058-F4 is a *c-Myc* inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

HY-143235

BRD4 Inhibitor-15	Epigenetic Reader Domain Apoptosis Bcl-2 Family Caspase c-Myc	Cancer
BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC₅₀ of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the *c-Myc* level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research.

HY-122683

sAJM589
c-Myc Cancer

sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC₅₀ of 1.8 μM.
HY-134975

NY2267
c-Myc Cancer

NY2267 is a disruptor of Myc-Max interaction, with an IC₅₀ of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.

sAJM589	c-Myc	Cancer
sAJM589 is a *Myc* inhibitor which potently disrupts the Myc-Max heterodimer with an IC₅₀ of 1.8 μM.

NY2267	c-Myc	Cancer
NY2267 is a disruptor of Myc-Max interaction, with an IC₅₀ of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.

HY-144878

VPC-70619	c-Myc	Cancer
VPC-70619 is a potent, orally active *N-Myc* inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration.

HY-12703

KSI-3716	c-Myc Autophagy	Cancer
KSI-3716 is a potent *c-Myc* inhibitor that blocks c-MYC/MAX binding to target gene promoters. KSI-3716 is an effective intravesical chemotherapy agent for bladder cancer.

HY-147973

IZTZ-1	c-Myc Apoptosis	Cancer
IZTZ-1, an imidazole-benzothiazole conjugate, is a *c-MYC* G4 ligand. IZTZ-1 is able to downregulate the c-MYC** expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research.

HY-147291

VPC-70063	c-Myc PARP Apoptosis	Cancer
VPC-70063 is a potent *Myc-Max* inhibitor with an IC₅₀ value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer.

HY-19735

KJ Pyr 9
c-Myc Autophagy Cancer

KJ Pyr 9 is an inhibitor of MYC with a K_d of 6.5 nM in in vitro assay.
HY-124129

10074-A4
c-Myc Cancer

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc_370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects.

KJ Pyr 9	c-Myc Autophagy	Cancer
KJ Pyr 9 is an inhibitor of *MYC* with a K_d of 6.5 nM in in vitro assay.

10074-A4	c-Myc	Cancer
10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc_370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects.

HY-N6747

Stauprimide	c-Myc Autophagy	Cancer
Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription.

HY-111411

IZCZ-3
c-Myc Autophagy Cancer

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.
HY-100996

10074-G5
c-Myc Autophagy Cancer

10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC₅₀ of 146 μM.
HY-103038

ML327
c-Myc Autophagy Cancer

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

IZCZ-3	c-Myc Autophagy	Cancer
IZCZ-3 is a potent *c-MYC* transcription** inhibitor with antitumor activity.

10074-G5	c-Myc Autophagy	Cancer
10074-G5 is an inhibitor of *c-Myc-Max* dimerization with an IC₅₀ of 146 μM.

ML327	c-Myc Autophagy	Cancer
ML327 is a blocker of *MYC* which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

HY-135691

hnRNPK-IN-1	c-Myc Apoptosis	Cancer
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with K_d values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities.

HY-124811

IRES-C11	c-Myc	Cancer
IRES-C11 is a spectfic *c-MYC* internal ribosome entry site (IRES)** translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes.

HY-114189

GW284543
UNC10225170
MEK Cancer

GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

GW284543 UNC10225170	MEK	Cancer
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

HY-114189A

GW284543 hydrochloride UNC10225170 hydrochloride	MEK	Cancer
GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

HY-153356

MRT-2359	Others	Cancer
MRT-2359 is an orally active and potent degrader of GSPT1 with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs).

HY-112929

DT-061
Phosphatase Cancer

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

DT-061	Phosphatase	Cancer
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

HY-N2068

Didymin	Apoptosis	Cancer
Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma.

HY-121418

Lusianthridin	c-Myc	Cancer
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

HY-136938

NEO2734 EP31670	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC₅₀ values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.

HY-151471

Anticancer agent 84	c-Myc	Cancer
Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer.

HY-80013A

THZ1 Hydrochloride	CDK	Cancer
THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC₅₀ of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.

HY-80013

THZ1	CDK	Cancer
THZ1 is a selective and potent covalent CDK7 inhibitor with an IC₅₀ of 3.2 nM. THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.

HY-13250

Silvestrol aglycone	Others	Cancer
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC₅₀s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity.

HY-114208

BI-9321	Histone Methyltransferase	Cancer
BI-9321 is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a K_d value of 166 nM. BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC₅₀ of 1.2 μM in U2OS cells.

HY-114208A

BI-9321 trihydrochloride	Histone Methyltransferase	Cancer
BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a K_d value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC₅₀ of 1.2 μM in U2OS cells.

HY-147261

B026	Histone Acetyltransferase	Cancer
B026 is a selective, potent, orally active p300/CBP histone acetyltransferase (HAT) inhibitor with IC₅₀ values of 1.8 nM and 9.5 nM for p300 and CBP enzyme, respectively. B026 has anticancer activity for androgen receptor-positive (AR+) prostate cancer cell lines.

HY-104072

BRD4-IN-3	Epigenetic Reader Domain	Infection Inflammation/Immunology
BRD4-IN-3 (compound 141) is a potent BRD4 inhibitor with an IC₅₀ of <0.5 µM. BRD4-IN-3 shows cytoxicity for MYC-Raji with an IC₅₀ value of >1 µM.

HY-147651

β-catenin-IN-4	β-catenin	Cancer
β-catenin-IN-4 (Compound 39) is a β-catenin inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc.

HY-112316

BAY1238097	Epigenetic Reader Domain	Cancer
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC₅₀ <100 nM).

HY-139361

Sulfopin PIN1-3	Others	Cancer
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent K_i of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors.

HY-123954

Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A51 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities.

HY-112799

DK419	Wnt β-catenin	Cancer
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

HY-124447

BTYNB	c-Myc	Cancer
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA (IC₅₀=5 μM). BTYNB exhibits selectivity and effectiveness against IMP1-postive cancer cell lines. BTYNB can be used for cancer research.

HY-109050

Alobresib GS-5829	Epigenetic Reader Domain	Cancer
Alobresib (GS-5829) is a BET bromodomain inhibitor, which represents a highly effective therapeutics agent against recurrent/chemotherapy resistant uterine serous carcinoma (USC) overexpressing c-Myc. Alobresib can be used in the metastatic castration-resistant prostate cancer (mCRPC) research.

HY-133131

PROTAC BRD4 Degrader-1	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress *c-Myc* expression.

HY-134333

ICCB280	Apoptosis	Cancer
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc).

HY-19759

SRT 2183	Sirtuin Apoptosis	Cancer
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

HY-17381A

Idarubicin 4-Demethoxydaunorubicin	Topoisomerase Bacterial Fungal Autophagy c-Myc DNA/RNA Synthesis Antibiotic	Cancer Infection
Idarubicin is an orally active and potent anthracycline antileukemic agent. Idarubicin inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin shows induction of DNA damage. Idarubicin inhibits DNA synthesis and of *c-myc* expression. Idarubicin inhibits the growth of bacteria and yeasts.

HY-129937A

GNE-987	PROTACs Epigenetic Reader Domain	Cancer
GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC₅₀=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC₅₀=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC).

HY-129937

(S)-GNE-987	PROTACs Epigenetic Reader Domain	Cancer
(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC₅₀=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

HY-128761

CBP/p300-IN-2	Epigenetic Reader Domain	Cancer
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 with IC₅₀ values of 1.07 nM and 5.96 nM for CBP/HTRF and Myc, respectively. CBP/EP300-IN-2, example 25, is extracted from patent WO2017205538A1.

HY-152471

Eleven-Nineteen-Leukemia Protein IN-3	Epigenetic Reader Domain	Cancer
Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC₅₀ value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro.

HY-120028

GNE-207	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC₅₀ of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC₅₀ of 18 nM for MYC expression in MV-4-11 cells.

HY-112316A

(R)-BAY1238097	Epigenetic Reader Domain	Cancer
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome.

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities.

HY-117203A

CDK12-IN-E9	CDK	Cancer
CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and a non-covalent CDK9 inhibitor, while avoiding ABC transporter-mediated efflux. CDK12-IN-E9 has weak binding ability to CDK7/CyclinH complex with an IC₅₀> 1 μM.

HY-146445

P300 bromodomain-IN-1	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC₅₀ of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells.

HY-N11576

Secalonic acid D	Apoptosis GSK-3 c-Myc β-catenin	Cancer
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates *c-Myc* expression, arrests cell cycle at G1 phase, induces cell apoptosis.

HY-13241

Ralimetinib dimesylate LY2228820 dimesylate	p38 MAPK Autophagy Apoptosis	Cancer Inflammation/Immunology
Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

HY-13241A

Ralimetinib LY2228820	p38 MAPK Autophagy	Cancer Inflammation/Immunology
Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

HY-126477

NNK	Endogenous Metabolite	Cancer
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser⁷⁰ and *c-Myc* at Thr⁵⁸ and Ser⁶² through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure.

HY-16291

APTO-253 LOR-253; LT-253	c-Myc KLF Apoptosis	Cancer Inflammation/Immunology
APTO-253 (LOR-253) is a small molecule that inhibits *c-Myc* expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor. APTO-253 has antiarthritic activity.

HY-148444

eIF4A3-IN-10	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-10 (compound 58) is a silvestrol (HY-13251) analogue. eIF4A3-IN-10 interferes the assembling of eIF4F translation complex with EC₅₀s of 35 and 100 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-10 can be used for the research of human cancer pathogenesis.

HY-112929B

(1S,2S,3R)-DT-061	Phosphatase	Cancer
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis.

HY-148448

eIF4A3-IN-14	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-14 (compound 51) is a silvestrol (HY-13251) analogue. eIF4A3-IN-14 interferes the assembling of eIF4F translation complex with EC₅₀s of 40 and 50 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-14 can be used for the research of human cancer pathogenesis.

HY-111784

Inobrodib CCS1477	Epigenetic Reader Domain	Cancer
Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with K_d values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a K_d of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression.

HY-148449

eIF4A3-IN-15	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-15 (compound 52) is a silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC₅₀s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis.

HY-148443

eIF4A3-IN-9	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-9 (compound 57) is a silvestrol (HY-13251) analogue. eIF4A3-IN-9 interferes the assembling of eIF4F translation complex with EC₅₀s of 29, 450 and 80 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-9 can be used for the research of human cancer pathogenesis.

HY-148451

eIF4A3-IN-17	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-17 (compound 61) is a silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC₅₀s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis.

HY-148450

eIF4A3-IN-16	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-16 (compound 60) is a silvestrol (HY-13251) analogue. eIF4A3-IN-16 interferes the assembling of eIF4F translation complex with EC₅₀s of 1, 30 and 1 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-16 can be used for the research of human cancer pathogenesis.

HY-148447

eIF4A3-IN-13	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-13 (compound 75) is a silvestrol (HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translation complex with EC₅₀s of 0.6, 15 and 0.4 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-13 can be used for the research of human cancer pathogenesis.

HY-145669

DIF-3	CDK GSK-3	Cancer
DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression.

HY-119271

CMLD010509 SDS-1-021	c-Myc Apoptosis	Cancer
CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC₅₀ below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism.

HY-148445

eIF4A3-IN-11	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-11 (compound 56) is a silvestrol (HY-13251) analogue. eIF4A3-IN-11 interferes the assembling of eIF4F translation complex with EC₅₀s of 0.2, 4 and 0.3 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-11 can be used for the research of human cancer pathogenesis.

HY-148446

eIF4A3-IN-12	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-12 (compound 62) is a silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC₅₀s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis.

HY-131203

PROTAC BRD4 Degrader-6	Epigenetic Reader Domain Apoptosis c-Myc Caspase	Cancer
PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 degrader with IC₅₀ value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research.

HY-151884

FUBP1-IN-2	c-Myc	Cancer
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both *c-Myc* mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines.

HY-N8146

Bruceantinol	STAT	Cancer Infection
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc.

HY-149209

LL-K8-22	CDK STAT Early 2 Factor (E2F)	Cancer
LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC₅₀ values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research.

HY-150684

GXH-II-052	Epigenetic Reader Domain	Cancer
GXH-II-052 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. GXH-II-052 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with K_d values of 28, 9.1, 4.8, 0.6, 8.4, 2.6 nM, respectively. GXH-II-052 shows antiproliferative activity. GXH-II-052 decreases the expression of c-Myc.

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Cancer Infection Metabolic Disease
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on *c-MYC, SKP2* and p27.

HY-150683

NC-III-49-1	Epigenetic Reader Domain	Cancer
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with K_d values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc.

HY-148452

eIF4A3-IN-18	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC₅₀ values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC₅₀ of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis.

HY-107738

Guggulsterone Z/E-Guggulsterone	Apoptosis JNK Akt Caspase FXR Autophagy	Cancer
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC₅₀s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

HY-112296

T025	CDK Apoptosis DYRK	Cancer
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with K_d values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC₅₀ values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research.

HY-136794

SB-284851-BT	p38 MAPK Epigenetic Reader Domain	Cancer Inflammation/Immunology
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC₅₀=1.7 µM), p38α (K_d=0.47 nM), BRDT (1) (IC₅₀=18 µM) and BRD4 (1)(IC₅₀=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates *c-Myc* and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET).

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library

776 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 776 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

HY-L039

Reprogramming Compound Library

1736 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 1736 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

HY-L109

Protein-protein Interaction Inhibitor Library

509 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.

However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 509 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P0312

*c-Myc* Peptide TFA**	Peptides	Cancer
c-Myc Peptide (TFA) is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein, and participates in regulation of growth-related gene transcription.

HY-P3720

YEQLRNSRA	Peptides	Cancer
YEQLRNSRA is a MycC Peptide. MycC Peptide is encoded by c-myc proto-oncogene, the c-myc oncogene has been implicated in malignant progression in a variety of human tumors. MycC Peptide regulates fundamental cellular processes like growth control, metabolism, proliferation, differentiation, and apoptosis.

Cat. No.	Product Name

HY-K0206

*Anti-c-Myc* Magnetic Beads**
MCE Anti-c-Myc Magnetic Beads are used for immunoprecipitation (IP) of specific c-Myc-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

HY-K0206A

*Anti-c-Myc* Magnetic Beads (1 μm)**
MCE Anti-c-Myc Magnetic Beads (1 μm) are used for immunoprecipitation (IP) of specific c-Myc-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems.

Cat. No.	Product Name	Target	Category

HY-N10790

RA-V	Wnt c-Myc Notch	Structural Classification Cyclopeptides Rubia cordifolia L. Rubiaceae Plants Source classification
RA-V is a cyclic hexapeptide. RA-V has activity against *Wnt, Myc* and Notch with IC₅₀** values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.

HY-N2068

Didymin	Apoptosis	Monophenols Phenols Flavonones Flavonoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Rutaceae Citrus
Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma.

HY-121418

Lusianthridin	c-Myc	Phenols Polyphenols Natural Products Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

HY-N11576

Secalonic acid D	Apoptosis GSK-3 c-Myc β-catenin	Structural Classification Natural Products Microorganisms Source classification
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates *c-Myc* expression, arrests cell cycle at G1 phase, induces cell apoptosis.

HY-N8146

Bruceantinol	STAT	Triterpenes Terpenoids Simaroubaceae Brucea antidysenterica J.F.Mill. Brucea javanica (L.) Merr. Plants Source classification Infection Disease Research Fields Cancer Classification of Application Fields
Bruceantinol, a quassinoid isolated from Brucea javanica, inhibits pepper mottle virus in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀=2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc.

HY-N0704

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Structural Classification Phenols Polyphenols Rosaceae Plants Agrimonia pilosa Ledeb. Metabolic Disease Disease Research Fields Classification of Application Fields
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on *c-MYC, SKP2* and p27.

HY-107738

Guggulsterone Z/E-Guggulsterone	Apoptosis JNK Akt Caspase FXR Autophagy	Triterpenes Structural Classification Terpenoids Burseraceae Plants Commiphora wightii Disease Research Fields Cancer Classification of Application Fields
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC₅₀s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Species:	Human (68) Virus (7) Rat (5) Mouse (30) Bovine (3) E.coli (12) Cynomolgus (1) Rabbit (2) Staphylococcus aureus (3) Pig (4)
Tag:	His (138) SUMO (17) Myc (137) GST (3) Fc (8) B2M (1) Flag (1)
Source:	HEK293 (34) Sf9 insect cells (21) P. pastoris (12) E. coli (78)

Cat. No.	Product Name	Species	Source

HY-P73832

MAX Protein, Human (sf9, His-GST)
Protein Max; MAX; BHLHD4; Myc-associated factor X
Human Sf9 insect cells
HY-P74380

BIN1 Protein, Human (His)
Myc box-dependent-interacting protein 1; BIN1; AMPHL; Amphiphysin II
Human E. coli
HY-P76542

PFDN5 Protein, Human (His)
Prefoldin subunit 5; Myc modulator 1; PFDN5; MM1; PFD5
Human E. coli
HY-P70388

MAX Protein, Human (His)
rHuMAX, His; Protein Max; Class D Basic Helix-Loop-Helix Protein 4; bHLHd4; ; Myc-Associated Factor X; MAX; BHLHD4
Human E. coli

HY-P71437

ZBTB17 Protein, Human (His) Zinc Finger and BTB Domain-Containing Protein 17; Myc-Interacting Zinc Finger Protein 1; Miz-1; Zinc Finger Protein 151; Zinc Finger Protein 60; ZBTB17; MIZ1; ZNF151; ZNF60	Human	E. coli

HY-P71623

SOST Protein, Rat (Myc, His)
Sost; Sclerostin
Rat E. coli
HY-P72281

Cathepsin W/CTSW, Mouse (His, myc)
CtswCathepsin W; Lymphopain
Mouse E. coli
HY-P72266

Frataxin/FXN Protein, Human (His, myc)
CyaY; FRDA; X25
Human E. coli

HY-P700253

*DHH Protein, Human (His-GST, Myc)* rHuDHH; DHH; HHG-3;	Human	E. coli
DHH Protein, Human (His-GST, Myc) is a single non-glycosylated polypeptide chain. Desert hedgehog protein (DHH) is a member of the Hedgehog family which encodes signaling molecules that play an important role in regulating morphogenesis.

HY-P72426

*BMP-15 Protein, Human (His, Myc)* Growth/differentiation factor 9B	Human	E. coli
Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth differentiation factor 9B (GDF9B), is a polymorphic ligand protein of the TGFβ family and is only expressed in follicular cells. BMP15 is closely related to GDF9 and synergistically regulates the genetic development of follicles. BMP15 is involved in p38 MAPK and HIF-1α/SCF signaling pathway, respectively, and can up-regulate the expression of anti-Mullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) related stem cell factor (SCF) in granulosa cells. The total length of human BMP-15 protein is 392 amino acids (M1-R392), with 4 glycosylation domains. BMP-15 Protein, Human (His, Myc) has a total length of 125 amino acids (Q268-R392), is expressed in E. coli cells with a N-terminal His-tag, a C-terminal Myc-tag, respectively.

HY-P72026

Transthyretin/TTR Protein, Human (HEK293, Fc-Myc)
ATTR Prealbumin; TBPA; PALB
Human HEK293
HY-P72268

Nucleoprotein/NP Protein, HCoV-NL63 (Sf9, His, myc)
Protein N
Virus Sf9 insect cells

HY-P72426A

*BMP-15 Protein, Human (His, Myc, soluition)* Growth/differentiation factor 9B	Human	E. coli
Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth differentiation factor 9B (GDF9B), is a polymorphic ligand protein of the TGFβ family and is only expressed in follicular cells. BMP15 is closely related to GDF9 and synergistically regulates the genetic development of follicles. BMP15 is involved in p38 MAPK and HIF-1α/SCF signaling pathway, respectively, and can up-regulate the expression of anti-Mullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) related stem cell factor (SCF) in granulosa cells. The total length of human BMP-15 protein is 392 amino acids (M1-R392), with 4 glycosylation domains. BMP-15 Protein, Human (His, Myc, soluition) is the protein in solution form, expressed in E. coli cells with a N-terminal His-tag and a C-terminal Myc-tag, respectively.

HY-P700258

Histone-lysine N-methyltransferase SMYD3(SMYD3) Protein, Human (His-Myc)
Human E. coli
HY-P71453

YebF Protein, E.coli (Myc, His)
yebF; b1847; JW1836; Protein YebF
E.coli E. coli
HY-P72059

Enterotoxin type A Protein, S. aureus (Baculovirus, His-Myc)
entAEnterotoxin type A; SEA
Staphylococcus aureus Sf9 insect cells
HY-P700002

Tenascin/Tnc protein, Mouse (His-Myc)
Tenascin; TN; Hexabrachion; Tenascin-C (TN-C)
Mouse HEK293
HY-P72084

Apolipoprotein E/APOE Protein, Rabbit (His-B2M, Myc)
APOEApolipoprotein E; Apo-E
Rabbit E. coli
HY-P72162

CYGB Protein, Rat (His-Myc)
Cygb; StapCytoglobin; Histoglobin; HGb; Stellate cell activation-associated protein
Rat E. coli
HY-P700002A

Tenascin/Tnc protein, Mouse (His-Myc, Solution)
Tenascin; TN; Hexabrachion; Tenascin-C (TN-C)
Mouse HEK293
HY-P71594

SRPX2 Protein, Mouse (Myc, His-SUMO)
Srpx2; Sushi repeat-containing protein SRPX2
Mouse E. coli
HY-P71656

Wnt8b Protein, Mouse (Myc, His-SUMO)
Wnt8b; Protein Wnt-8b
Mouse E. coli
HY-P72039

SARS-CoV-2 S glycoprotein (HEK293, His-Myc)
S glycoprotein; E2; Peplomer protein
Virus HEK293
HY-P700312

T4 gp32 Protein, T4 phage (His, Myc)
gp32, Helix-destabilizing protein
Others E. coli
HY-P71805

Insulin-1/Ins1 Protein, Mouse (P.pastoris, Myc, His)
Ins1; Ins-1; Insulin-1
Mouse P. pastoris
HY-P72167

DBI Protein, Mouse (His-Myc)
DbiAcyl-CoA-binding protein; ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP
Mouse E. coli
HY-P72300

Protein L1/VACWR088, Vaccinia virus (Sf9, His, myc)
Virion membrane protein M25
Virus Sf9 insect cells
HY-P71555

CDTB Protein, E.coli (Myc, His-SUMO)
cdtB; Cytolethal distending toxin subunit B; CDT B; Deoxyribonuclease CdtB
E.coli E. coli
HY-P71629

Collectrin Protein, Mouse (Myc, His-SUMO)
Cltrn; Nx17; Tmem27Collectrin; Transmembrane protein 27
Mouse E. coli
HY-P71800

PhoP Protein, E.coli (P.pastoris, Myc, His)
phoP; b1130; JW1116; Transcriptional regulatory protein PhoP
E.coli P. pastoris
HY-P72030

BTLA/CD272 Protein, Human (HEK293, hFc-Myc)
B- and T-lymphocyte-associated protein; CD272;
Human HEK293
HY-P72302

Intermediate capsid protein VP6, Rotavirus A (sf9, His, myc )
Intermediate capsid protein VP6
Virus Sf9 insect cells
HY-P72301

Protein L1/L1R, Vaccinia virus (Sf9, His, myc)
Virion membrane protein M25
Virus Sf9 insect cells
HY-P72265

Neurofilament light polypeptide/NEFL, Human (His-SUMO, myc)
CMT1F; CMT2E; NEFL; NF68
Human E. coli
HY-P75216

FABP4 Protein, Mouse (HEK293, His-MYC)
Adipocyte-type fatty acid-binding protein; Fabp4; AFABP
Mouse HEK293
HY-P71805Y

Insulin-1/Ins1 Protein, Mouse (P.pastoris, Myc, His, solution)
Ins1; Ins-1; Insulin-1
Mouse P. pastoris
HY-P71475

Propionate kinase/TdcD Protein, E.coli (Myc, His)
tdcD; c3873; Propionate kinase; EC 2.7.2.15
E.coli E. coli
HY-P71747

IRF3 Protein, Mouse (P.pastoris, Myc, His)
Irf3; Interferon regulatory factor 3; IRF-3
Mouse P. pastoris
HY-P71818

MAdCAM1 Protein, Human (P.pastoris, His-Myc)
Addressin mucosal; hMAdCAM 1 ; hMAdCAM-1; MACAM1
Human P. pastoris
HY-P72105

BLM Protein, Mouse (His-Myc)
BlmBloom syndrome protein homolog; mBLM; EC 3.6.4.12; RecQ helicase homolog
Mouse E. coli
HY-P72279

Outer membrane protein F/OmpF Protein, E.coli (His, myc)
Outer membrane protein B; Outer membrane protein IA
E.coli E. coli
HY-P700411

GCGR Protein, Human (HEK293, N-His, C-Myc)
glucagon receptor; GGR; GL-R; FLJ97182; MGC138246
Human HEK293
HY-P71492

TalB Protein, E.coli (Myc, His)
talB; yaaK; b0008; JW0007; Transaldolase B; EC 2.2.1.2
E.coli E. coli
HY-P71494

Outer membrane protein X/OmpX Protein, E.coli (Myc, His)
ompX; Z1036; ECs0892; Outer membrane protein X
E.coli E. coli
HY-P72057

PLY Protein, Streptococcus pneumoniae serotype 4 (Baculovirus, His-Myc)
ply; SP_1923; Pneumolysin; Ply; Thiol-activated cytolysin
Others Sf9 insect cells
HY-P71633

Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO)
Jag1; Protein jagged-1; Jagged1; CD antigen CD339
Mouse E. coli
HY-P71678

FAM167A Protein, Human (HEK293, Myc, His)
FAM167A; C8orf13Protein FAM167A
Human HEK293
HY-P72079

Annexin A4/ANXA4 Protein, Mouse (His-Myc)
Anxa4; Anx4Annexin A4; Annexin IV; Annexin-4
Mouse E. coli
HY-P72289

Leukocyte elastase inhibitor/SERPINB1 Protein, Pig (His, myc)
SERPINB1; ELANH2Leukocyte elastase inhibitor; LNPI; Serpin B1
Pig E. coli
HY-P72269

HCoV-OC43 Spike/S Protein (Sf9, His, myc)
E2; Peplomer protein ; Human coronavirus OC43 Spike glycoprotein
Virus Sf9 insect cells
HY-P700601

TSLP Protein, Human (HEK293, His-Myc)
Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; Tslp; TSLP protein; TSLP_HUMAN
Human HEK293
HY-P71454

Leukocidin-F subunit/LukF Protein, S. aureus (Myc, His-SUMO)
lukF; Leukocidin-F subunit; Gamma-hemolysin; H-gamma-I subunit
Staphylococcus aureus E. coli
HY-P71787

SPRR2B Protein, Human (P.pastoris, Myc, His)
SPRR2B; Small proline-rich protein 2B; SPR-2B
Human P. pastoris
HY-P72214

GSTP1 Protein, Cricetulus longicaudatus (His-Myc)
GSTP1Glutathione S-transferase P; EC 2.5.1.18; GST class-pi
Others E. coli
HY-P71505

HLA-DRB1 Protein, Human (Myc, His-SUMO)
HLA class II histocompatibility antigen, DRB1 beta chain; Human leukocyte antigen DRB1
Human E. coli
HY-P71515

BamA Protein, E.coli (Myc, His)
bamA; yaeT; yzzN; yzzY; b0177; JW0172Outer membrane protein assembly factor BamA; Omp85
E.coli E. coli
HY-P72045

SARS-CoV S Protein (HEK293, His-Myc)
S glycoprotein; E2; Peplomer protein; Spike protein S1; Spike protein S2;
Virus HEK293
HY-P72050

GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc)
GSTP1Glutathione S-transferase P; EC 2.5.1.18; GST class-pi
Others Sf9 insect cells
HY-P73882

IL-35 Protein, Human (HEK293, His-hFc-Myc)
CLMF; IL-12A; IL-35; Interleukin-35; NFSK; NKSF1; P35
Human HEK293
HY-P76058

Serglycin/SRGN Protein, Human (HEK293, His-Myc)
Hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; SRGN; PRG; PRG1
Human HEK293
HY-P700409

EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc)
Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1
Human HEK293
HY-P72286

Outer membrane protein C/OmpC Protein, Klebsiella pneumoniae (His, myc)
Outer membrane porin C; Outer membrane protein C; Porin OmpC; Porin ompk36
Others E. coli
HY-P700308

Stratifin Protein, Human (N-His, C-Myc)
14-3-3 Protein Sigma; Epithelial Cell Marker Protein 1; Stratifin; SFN; HME1
Human E. coli
HY-P72053

PKM2 Protein, Mouse (Baculovirus, His-Myc)
Pkm; Pk3; Pkm2; PykmPyruvate kinase PKM; EC 2.7.1.40; Pyruvate kinase muscle isozyme
Mouse Sf9 insect cells

HY-P72074

*AICDA Protein, Mouse (His-Myc)* Aicda; Aid; Single-stranded DNA cytosine deaminase; EC 3.5.4.38; Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase	Mouse	E. coli
AICDA Protein, Mouse (His-Myc) is an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells. AICDA Protein overexpression causes more aggressive disease in BCL2-driven murine lymphomas.

HY-P71499

MBP/MalE Protein, E.coli (Myc, His)
malE; b4034; JW3994; Maltose/maltodextrin-binding periplasmic protein; MMBP; Maltodextrin-binding protein; Maltose-binding protein; MBP
E.coli E. coli
HY-P71550

ATP5MG Protein, Bovine (Myc, His)
ATP5MG; ATP5LATP synthase subunit g; mitochondrial; ATPase subunit g; ATP synthase membrane subunit g
Bovine E. coli
HY-P71631

PITHD1 Protein, Human (Myc, His)
PITHD1; C1orf128; AD039; HT014; PP603; PITH domain-containing protein 1
Human E. coli
HY-P71739

EGLP/GPX5 Protein, Pig (P.pastoris, Myc, His)
GPX5; Epididymal secretory glutathione peroxidase; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5
Pig P. pastoris
HY-P72047

APT Protein, Streptococcus pyogenes serotype M1 (Baculovirus, His-Myc)
apt; SPy_0927; M5005_Spy0728Adenine phosphoribosyltransferase; APRT; EC 2.4.2.7
Others Sf9 insect cells
HY-P700414

Glypican-3/GPC3 Protein, Human (HEK293, His-Myc)
Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5
Human HEK293
HY-P700529

AIF1 Protein, Bovine (N-His, C-Myc)
allograft inflammatory factor 1; IBA1; IRT1; AIF-1; IRT-1; protein G1
Bovine E. coli

HY-P7405

*SIRP alpha/CD172a Protein, Human (HEK293, His-Myc)* rHuSignal regulatory protein α, His; CD172a; SHPS-1; BIT; MYD1	Human	HEK293
SIRP alpha/CD172a Protein, Human (P78324, HEK293, His) is a polypeptide chain amino acids with the C-termimal His tag. Signal regulatory protein alpha (SIRPα, designated CD172a) is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily.

HY-P71485

Gamma-hemolysin component A Protein, S. aureus (Myc, His)
hlgA; hlg2; MW2342; Gamma-hemolysin component A; H-gamma-2; H-gamma-II
Staphylococcus aureus E. coli
HY-P71669

PAEP Protein, Human (HEK293, Myc, His)
Alpha uterine protein; gD; GdA; GdF; GdS; Glycodelin A; Glycodelin; Glycodelin F; Glycodelin S; MGC138509; MGC142288; PAEG
Human HEK293
HY-P72235

HPSE Protein, Rat (His-Myc)
Hpse; HepHeparanase; EC 3.2.1.166; Endo-glucoronidase; Heparanase 8 kDa subunit; Heparanase 50 kDa subunit
Rat E. coli
HY-P72021

Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc)
Sialic acid-binding Ig-like lectin 3 Siglec-3; gp67; CD33; SIGLEC3
Human HEK293
HY-P72293

Group XV phospholipase A2/Pla2g15, Mouse (His, myc)
Group XV phospholipase A2; 1-O-acylceramide synthase; ACS; LLPL; Lysosomal phospholipase A2
Mouse E. coli
HY-P700435

4-1BBL/TNFSF9 Protein, Human (HEK293, hFc-Myc)
Tumor necrosis factor ligand superfamily member 9; CD137L; 4-1BB Ligand
Human HEK293
HY-P71451

TPP2 Protein, Human (Myc, His)
TPP2; Tripeptidyl-peptidase 2; TPP-2; EC 3.4.14.10; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II; TPP-II
Human E. coli

HY-P72033

*LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc)* Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD258; HVEML; LIGHT; UNQ391; PRO726;	Human	HEK293
LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type . LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNγ, triggering tumor apoptosis signal . LIGHT/TNFSF14 is also involved in the dominant LTβR-NIK-p52 NF-κB pathway promoting the expression of inflammatory gene. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal hFc- and Myc-tag.

HY-P72061

*ADAM12 Protein, Mouse (Baculovirus, His-Myc)* Adam12; MltnaDisintegrin and metalloproteinase domain-containing protein 12; ADAM 12; EC 3.4.24.-; Meltrin-alpha	Mouse	Sf9 insect cells
ADAM12 Protein, Mouse (Baculovirus, His-Myc) is a disintegrin and a metalloprotease. ADAM12 is upregulated in epithelial cancers and contributes to increased tumor proliferation, metastasis, and endocrine resistance.

HY-P72089

ARF1 Protein, Human (His-GST, Myc)
ADP Ribosylation Factor 1; ADP-ribosylation factor 1; ARF 1; ARF1; ARF1_HUMAN
Human E. coli

HY-P72244

*IFN-alpha 6/IFNA6 Protein, Human (His-Myc)* IFNA6Interferon alpha-6; IFN-alpha-6; Interferon alpha-54; Interferon alpha-K; LeIF K	Human	E. coli
IFN-alpha 6 (IFNA6), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 6/IFNA6 Protein, Human (His-Myc) contains 169 a.a. (S21-E189), produced in E. coli cells with a N-terminal His-tag and a C-terminal Myc-tag.

HY-P71591

cGB-PDE Protein, Mouse (Myc, His)
Pde5a; Pde5; cGMP-specific 3',5'-cyclic phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE
Mouse E. coli

HY-P71838

*BPHL Protein, Human (P.pastoris, His-Myc)* Biphenyl hydrolase like; Biphenyl hydrolase related; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Bphl; Bphrp; VACVase; Valacyclovir hydrolase; Valacyclovirase	Human	P. pastoris

HY-P71839

HSD17B13 Protein, Human (P.pastoris, His-Myc)
HSD17B13; SCDR9; SDR16C3; HMFN0376; 17-beta-hydroxysteroid dehydrogenase 13
Human P. pastoris
HY-P72062

NEU2 Protein, Cricetulus griseus (Baculovirus, His-Myc)
NEU2; Sialidase-2; EC 3.2.1.18; Cytosolic sialidase; N-acetyl-alpha-neuraminidase 2
Others Sf9 insect cells
HY-P71579

TFIIF-associating CTD phosphatase Protein, Mouse (Myc, His)
Ctdp1; Fcp1; RNA polymerase II subunit A C-terminal domain phosphatase; EC 3.1.3.16; TFIIF-associating CTD phosphatase
Mouse E. coli

HY-P700513

*MIF Protein, Human (N-His, C-Myc)* MIF; macrophage migration inhibitory factor; GIF; GLIF; MMIF; phenylpyruvate tautomerase; glycosylation-inhibiting factor; EC 5.3.2.1; Glycosylation-inhibiting factor; Phenylpyruvate tautomerase	Human	E. coli

HY-P71448

*ITGBL1 Protein, Human (Myc, His)* ITGBL1; OSCP; TIED; Integrin beta-like protein 1; Osteoblast-specific cysteine-rich protein; Ten integrin EGF-like repeat domain-containing protein	Human	E. coli

HY-P71568

*MUSK Protein, Mouse (Myc, His-SUMO)* Musk; Nsk2; Muscle; skeletal receptor tyrosine-protein kinase; EC 2.7.10.1; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor	Mouse	E. coli

HY-P71610

Outer membrane porin C/OmpC Protein, E.coli (Myc, His-SUMO)
ompC; Z3473; ECs3104; Outer membrane porin C; Outer membrane protein 1B; Outer membrane protein C; Porin OmpC
E.coli E. coli

HY-P700564

*Galanin Protein, Human (N-His, C-Myc)* GAL; galanin prepropeptide; galanin , GALN; galanin peptides; galanin message associated peptide; GLNN; GMAP; galanin-related peptide; galanin-message-associated peptide; GALN; MGC40167	Human	E. coli

HY-P71479

*AlkB Protein, E.coli (Myc, His-SUMO)* alkB; aidD; b2212; JW2200Alpha-ketoglutarate-dependent dioxygenase AlkB; EC 1.14.11.33; Alkylated DNA repair protein AlkB; DNA oxidative demethylase AlkB	E.coli	E. coli
AlkB Protein, E.coli (Myc, His-SUMO) is a protein found in E. coli, plays a major role in oxidative dealkylation processes.

HY-P72060

*ACPS Protein, Streptococcus pyogenes serotype M28 (Baculovirus, His-Myc)* acpS; M28_Spy1523Holo-[acyl-carrier-protein] synthase; Holo-ACP synthase; EC 2.7.8.7; 4'-phosphopantetheinyl transferase AcpS	Others	Sf9 insect cells
ACPS Protein, Streptococcus pyogenes serotype M28 (Baculovirus, His-Myc), a 4-phosphopantetheinyl transferase, activates two distinct acyl carrier proteins (ACPs) that are present in fatty acid synthase (FAS) systems FAS-I and FAS-II, the ACP-I domain and the mycobacterial ACP-II protein (ACPM), respectively.

HY-P71576

ATG14 Protein, Human (Myc, His)
4832427M01; ATG14; Atg14L; Autophagy-related protein 14-like protein; Barkor; Beclin 1-associated autophagy-related key regulator; D14Ertd114e
Human E. coli
HY-P72023

ULBP1/RAET1I Protein, Human (HEK293, Fc-Myc)
ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; Retinoic acid early transcript 1I
Human HEK293
HY-P700645

SIRP beta 1 Protein, Human (HEK293, His-Myc)
Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b; SIRPB1
Human HEK293

HY-P72063

*NRROS Protein, Human (Baculovirus, His-Myc)* NRROS; LRRC33; UNQ3030/PRO9833Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species	Human	Sf9 insect cells

HY-P72211

*EGLP/GPX5 Protein, Pig (His-Myc)* GPX5Epididymal secretory glutathione peroxidase; EC 1.11.1.9; Epididymis-specific glutathione peroxidase-like protein; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5	Pig	E. coli

HY-P700412

GH1/Somatotropin Protein, Human (HEK293, N-His, C-Myc)
GH; GH-N; GHN; hGH-N; Growth hormone; Pituitary growth hormone; growth hormone 1; GH1; IGHD1B; Somatotropin; hGH
Human HEK293
HY-P700487

FGF2 Protein, Chicken (N-His, C-Myc)
Fibroblast Growth Factor 2; FGF-2; Basic Fibroblast Growth Factor; bFGF; Heparin-Binding Growth Factor 2; HBGF-2; Fgf2; Fgf-2
Others E. coli
HY-P700632

IL-17A Protein, Pig (N-His, C-Myc)
Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
Pig E. coli

HY-P72054

*RCVRN Protein, Human (Baculovirus, His-Myc)* 23 kDa photoreceptor cell-specific protein; Cancer associated retinopathy protein; Cancer-associated retinopathy protein; CAR; CAR protein; p26; Protein CAR; RCV1; RCVRN; RECO_HUMAN; Recoverin; S-modulin	Human	Sf9 insect cells

HY-P700468

GLP1R Protein, Human (HEK293, N-His, C-Myc)
rHuGlucagon-like peptide 1 receptor/GLP1R, Fc; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R
Human HEK293
HY-P71638

Elastase IIIB/CELA3B Protein, Mouse (Myc, His)
Cela3b; Ela3; Ela3b; Chymotrypsin-like elastase family member 3B; EC 3.4.21.70; Elastase IIIB; Elastase-3B; Protease E
Mouse E. coli

HY-P71666

*GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His)* Gucy2c; Guc2c; Heat-stable enterotoxin receptor; STA receptor; EC 4.6.1.2; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase	Rat	HEK293

HY-P700512

*GM-CSF Protein, Bovine (P. pastoris, His-Myc)* colony stimulating factor 2 (granulocyte-macrophage); GMCSF; MGC131935; MGC138897; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; colony-stimulating factor; granulocyte-macrophage colony stimulating factor	Bovine	P. pastoris

HY-P71457

*Dxr/DXP reductoisomerase Protein, E.coli (Myc, His)* dxr; ispC; yaeM; b0173; JW01681-deoxy-D-xylulose 5-phosphate reductoisomerase; DXP reductoisomerase; EC 1.1.1.267; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase	E.coli	E. coli

HY-P71561

CMRF35-like molecule 1 Protein, Rat (Myc, His-SUMO)
Cd300lf; Clm1CMRF35-like molecule 1; CLM-1; CD300 antigen-like family member F; CD antigen CD300f
Rat E. coli

HY-P71677

*FAM20C Protein, Human (HEK293, Myc, His)* C76981; Dentin matrix protein 4; Family with sequence similarity 20 member C; GEF CK; Golgi enriched fraction casein kinase; Protein FAM20C; RNS	Human	HEK293

HY-P71639

*CORS26 Protein, Mouse (Myc, His)* C1qtnf3; Cors26; Ctrp3; Complement C1q tumor necrosis factor-related protein 3; Collagenous repeat-containing sequence 26kDa protein; CORS26; Secretory protein CORS26	Mouse	E. coli

HY-P700488

*HDGF Protein, Mouse (P. pastoris, N-His, C-Myc)* rHuHepatoma-derived growth factor/HDGF, His; Hepatoma-Derived Growth Factor; HDGF; High Mobility Group Protein 1-Kike 2; HMG-1L2; HDGF; HMG1L2	Mouse	P. pastoris

HY-P700467

*TPBG/5T4 Protein, Cynomolgus (HEK293, N-His, C-Myc)* rCynTrophoblast glycoprotein/5T4, His; TPBG; 5T4 Protein, Human; 5T4AG Protein, Human; M6P1 Protein, Human; WAIF1 Protein, Human	Cynomolgus	HEK293

HY-P70260

Enolase 1/ENO1 Protein, Human (His) rHuAlpha-enolase, His; Alpha-enolase; 2-phospho-D-glycerate hydro-lyase; C-Myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli
Alpha-enolase/Enolase 1 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Alpha-enolase, a multifunctional protein, is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells.

HY-P71658

OARD1 Protein, Human (Myc, His)
C6orf130; CF130_HUMAN; Chromosome 6 open reading frame 130; dJ34B21.3; O acetyl ADP ribose deacetylase C6orf130; Uncharacterized protein C6orf130
Human E. coli

HY-P72049

*CYP51 Protein, Mycobacterium tuberculosis (Baculovirus, His-Myc)* cyp51; MT0788Lanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	Sf9 insect cells

HY-P700010

*Flap endonuclease 1/FEN-1 Protein, Human (His, Myc)* rHuFlap endonuclease 1/FEN-1; Flap Endonuclease 1; FEN-1; DNase IV; Flap Structure-Specific Endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli

HY-P700501

*OX40 Ligand/TNFSF4 Protein, Rabbit (P. pastoris, His-Myc)* Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1	Rabbit	P. pastoris

HY-P700532

*IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc)* CXCL10; SCYB10C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10	Human	HEK293

HY-P700602

*PADI2 Protein, Human (HEK293, N-His, C-Myc)* PADI2; PAD2; PDI2; PAD-H19; protein-arginine deiminase type-2; protein-arginine deiminase type II; NP_031391.2; EC 3.5.3.15; peptidyl arginine deiminase, type II	Human	HEK293

HY-P700603

GUCY2C/Guanylyl cyclase C Protein, Mouse (HEK293, N-His, C-Myc)
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL
Mouse HEK293

HY-P71636

*CD367/CLEC4A Protein, Mouse (Myc, His-SUMO)* Clec4a; Clec4a2; Clecsf6; DcirC-type lectin domain family 4 member A; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; CD antigen CD367	Mouse	E. coli

HY-P71645

*AK3 Protein, Human (Myc, His)* Adenylate kinase 3 alpha-like 1; Adenylate kinase 3; Adenylate kinase 3, formerly; adenylate kinase 6, adenylate kinase 3 like 1; AK 3; mitochondrial	Human	E. coli
AK3 Protein, Human (Myc, His) is a mitochondrial protein and is localized in the mitochondrial matrix.

HY-P70260A

Enolase 1/ENO1 Protein, Human (C-His) rHuAlpha-enolase, His; Alpha-enolase; 2-phospho-D-glycerate hydro-lyase; C-Myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein; ENO1	Human	E. coli

HY-P700433

*CD30/TNFRSF8 Protein, Human (HEK293, N-His, C-Myc)* rHuTumor necrosis factor receptor superfamily member 8/CD30, His; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8	Human	HEK293

HY-P70886

NDRG1 Protein, Human (His) Protein NDRG1; Differentiation-Related Gene 1 Protein; DRG-1; N-Myc Downstream-Regulated Gene 1 Protein; Nickel-Specific Induction Protein Cap43; Reducing Agents and TunicaMycin-Responsive Protein; RTP; Rit42; NDRG1; CAP43; DRG1; RTP	Human	E. coli

HY-P71635

SNTG1 Protein, Human (Myc, His)
G1SYN; Gamma 1 syntrophin; SNTG 1; Sntg1; SNTG1_HUMAN; SYN 4; SYN4; Synotrophin gamma 1; Syntrophin 4; Syntrophin gamma 1; Syntrophin-4
Human E. coli

HY-P71548

*JMJD1C Protein, Human (His-SUMO-Myc)* Jmjd1c; Jumonji domain containing 1C ; Jumonji domain-containing protein 1C; Probable JmjC domain-containing histone demethylation protein 2C; Thryoid receptor interacting protein; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8; TRIP8	Human	E. coli

HY-P700541

CCR2 Protein, Mouse (N-His, C-Myc)
CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2
Mouse E. coli

HY-P71572

*SH3PXD2A Protein, Human (Myc, His)* Adapter protein TKS5; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains protein 1; Sh3md1; Sh3pxd2a; SPD2A_HUMAN; TKs5; Tyrosine kinase substrate with five SH3 domains	Human	E. coli

HY-P700441

*DNAM-1 Protein, Human (HEK293, hFc, Myc)* CD226; CD226 molecule; CD226 antigen; DNAM 1; DNAM1; PTA1; TLiSA1; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen; DNAM-1	Human	HEK293

HY-P700449

*GFRA1/GDNFR-alpha-1 Protein, Mouse (HEK293, N-His, C-Myc)* rHuGDNF family receptor alpha-1/GFRA1, His; GFRα1; GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1	Mouse	HEK293

HY-P72134

*CEBP delta/CEBPD Protein, Human (His-Myc)* C/EBP delta; C/EBP related protein 3; CCAAT/enhancer binding protein C/EBP; delta; CCAAT/enhancer binding protein delta; CCAAT/enhancer-binding protein delta; CEBP D; CEBPD; CEBPD_HUMAN; CELF; Crp 3; Crp3; NF IL6 beta; NF-IL6-beta; Nuclear factor NF IL6 beta; Nuclear factor NF-IL6-beta	Human	E. coli

HY-P700417

*L1CAM Protein, Human (HEK293, N-His, C-Myc)* L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1	Human	HEK293

HY-P700616

*ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc)* anoctamin 1, calcium activated chloride channel; oral cancer overexpressed 2, ORAOV2, TMEM16A, transmembrane protein 16A; anoctamin-1; DOG1; FLJ10261; TAOS2; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); ORAOV2; TMEM16A	Human	E. coli

HY-P71585

*KDM3B Protein, Human (Myc, His-SUMO)* 5qNCA; C5orf7; JHDM2B; JmjC domain containing histone demethylation protein 2B; JmjC domain-containing histone demethylation protein 2B; jmjd1b; Jumonji domain containing 1B; Jumonji domain containing protein 1B; Jumonji domain-containing protein 1B; KDM3B; KDM3B_HUMAN; KIAA1082; Lysine (K) specific demethylase 3B ; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA	Human	E. coli

HY-P72056

*TRA2B Protein, Human (Baculovirus, His-Myc)* arginine/serine-rich 10; Arginine/serine-rich splicing factor 10; hTRA2-beta; SFRS10; Splicing factor; Splicing factor arginine/serine rich 10; SRFS10; TRA-2 beta; TRA2-beta; Tra2b; TRA2B_HUMAN; TRAN2B; Transformer 2 beta homolog; Transformer-2 protein homolog B; Transformer-2 protein homolog beta; Transformer-2-beta	Human	Sf9 insect cells

HY-P700567

*PLA2G7 Protein, Mouse (Baculovirus, N-His, C-Myc)* PLA2G7; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); platelet-activating factor acetylhydrolase; LDL PLA2; PAFAH; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; PAFAD; LP-PLA2; LDL-PLA2	Mouse	Sf9 insect cells

HY-P700568

*PLA2G7 Protein, Mouse (HEK293, N-His, C-Myc)* PLA2G7; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); platelet-activating factor acetylhydrolase; LDL PLA2; PAFAH; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; PAFAD; LP-PLA2; LDL-PLA2	Mouse	HEK293

HY-P72052

*KRT8 Protein, Human (Baculovirus, His-Myc)* CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8 ; Keratin; type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8	Human	Sf9 insect cells

HY-P72197

*FOXM1 Protein, Human (His, SUMO-Myc)* FKHL16; Forkhead box M1; Forkhead box protein M1; forkhead like 16; Forkhead-related protein FKHL16; FOX M1; Foxm1; FOXM1_HUMAN; FOXM1B; HFH-11; HFH11; HNF-3/fork-head homolog 11; HNF3; INS1; M phase phosphoprotein 2; M-phase phosphoprotein 2; MPHOSPH2; MPP2; PIG29; TGT3; Transcription factor Trident; Trident; WIN; Winged-helix factor from INS1 cells	Human	E. coli

HY-P72066

*ISCU Protein, Human (Baculovirus, His-Myc)* 2310020H20Rik; HML; hnifU; Iron sulfur cluster assembly enzyme ISCU mitochondrial; Iron sulfur cluster scaffold homolog E. coli; ; Iron sulfur cluster scaffold homolog; Iron-sulfur cluster assembly enzyme ISCU; Iscu; IscU iron sulfur cluster scaffold homolog; ISCU_HUMAN; ISU2; MGC74517; mitochondrial; NIFU; NifU like N terminal domain containing; NifU like N terminal domain containing protein; NifU like protein; NifU-like N-terminal domain-containing protein; NifU-like protein; NIFUN; Nitrogen fixation cluster like; OTTHUMP00000238760; OTTHUMP00000238761; OTTHUMP00000238762; OTTHUMP00000238764; OTTHUMP00000238765	Human	Sf9 insect cells

HY-P72159

*CXCR4 Protein, Human (N-His-SUMO, C-Myc)* C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; SDF 1 receptor; SDF-1 receptor; WHIM; WHIMS	Human	E. coli

Cat. No.	Product Name	Application	Reactivity

HY-P80804

*Phospho-c-Myc* (Ser62) Rabbit mAb** Myc; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64		Mouse, Rat
Rabbit Monoclonal Antibody to c-Myc (phospho S62)

HY-P80626

*c-Myc* Rabbit mAb** Myc; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64		Human, Mouse, Rat
Rabbit Monoclonal Antibody to c-Myc

HY-P80232

Myc-tag Mouse mAb

Mouse Monoclonal Antibody to Myc tag
HY-P80511

Phospho-c-Myc(S62) Rabbit mAb
Human

Rabbit Monoclonal Antibody to c-Myc(Phospho S62)