1. MAPK/ERK Pathway
  2. MEK
  3. GW284543

GW284543 (Synonyms: UNC10225170)

Cat. No.: HY-114189 Purity: 99.86%
Handling Instructions

GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 (UNC10225170) reduces pERK5, and decreases endogenous MYC protein.

For research use only. We do not sell to patients.

GW284543 Chemical Structure

GW284543 Chemical Structure

CAS No. : 790186-68-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 (UNC10225170) reduces pERK5, and decreases endogenous MYC protein[1].

IC50 & Target[1]

MEK5

 

Molecular Weight

372.42

Formula

C₂₃H₂₀N₂O₃

CAS No.

790186-68-4

SMILES

COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (335.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6851 mL 13.4257 mL 26.8514 mL
5 mM 0.5370 mL 2.6851 mL 5.3703 mL
10 mM 0.2685 mL 1.3426 mL 2.6851 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.86%

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Product Name:
GW284543
Cat. No.:
HY-114189
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