1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MEK
  4. MEK1 Inhibitors

MEK1 Inhibitors

MEK1

MEK2

MEK5

MEK

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Sorry. There is currently no product that acts on isoform MEK1 together.

Please try each isoform separately.

MEK1 Specific Inhibitors & Antagonists
Product Name MEK1 MEK2 MEK MEK1 Selectivity Purity
Cobimetinib
MEK1, IC50: 4.2 nM
    Selective Inhibitor 99.70%
CI-1040
MEK1, IC50: 17 nM
    Selective Inhibitor 99.79%
Isorhamnetin
MEK1
    Selective Inhibitor 99.95%
GDC-0623
MEK1, Ki: 0.13 nM (+ATP)
    Selective Inhibitor 99.15%
Cobimetinib hemifumarate
MEK1, IC50: 4.2 nM
    Selective Inhibitor >99.0%
APS-2-79
MEK1
    Selective Antagonist 99.31%
U0126-EtOH
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
  Pan Inhibitor 98.70%
Trametinib
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
  Pan Inhibitor 99.44%
PD98059
MEK1, IC50: 2-7 μM
MEK2, IC50: 50 μM
  Pan Inhibitor 99.84%
PD0325901
MEK1, Ki: 1 nM
MEK2, Ki: 1 nM
MEK, IC50: 0.33 nM
Pan Inhibitor 99.95%
Selumetinib
MEK1, IC50: 14 nM
 
MEK, IC50: 12 nM
Pan Inhibitor 99.87%
U0126
MEK1, IC50: 70 nM
MEK2, IC50: 60 nM
  Pan Inhibitor
Trametinib (DMSO solvate)
MEK1, IC50: 2 nM
MEK2, IC50: 2 nM
  Pan Inhibitor 99.77%
Pimasertib
MEK1
MEK2
  Pan Inhibitor 99.70%
Refametinib
MEK1, IC50: 19 nM
MEK2, IC50: 47 nM
  Pan Inhibitor 99.82%
Theaflavin 3,3'-digallate
MEK1
MEK2
  Pan Inhibitor 99.73%
SL327
MEK1, IC50: 180 nM
MEK2, IC50: 220 nM
  Pan Inhibitor >98.0%
RO4987655
MEK1, IC50: 5.2 nM
MEK2, IC50: 5.2 nM
  Pan Inhibitor 99.17%
AZD8330
MEK1, IC50: 7 nM
MEK2, IC50: 7 nM
  Pan Inhibitor 99.14%
Hypothemycin
MEK1, Ki: 17 nM
MEK2, Ki: 38 nM
  Pan Inhibitor
PD0325901-O-C2-dioxolane
MEK1
MEK2
  default Inhibitor