1. Signaling Pathways
  2. MAPK/ERK Pathway
  3. MEK
  4. MEK2 Inhibitors

MEK2 Inhibitors

MEK1

MEK2

MEK5

MEK

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Sorry. There is currently no product that acts on isoform MEK2 together.

Please try each isoform separately.

MEK2 Specific Inhibitors
Product Name MEK2 MEK1 MEK MEK2 Selectivity Purity
Trametinib
MEK2, IC50: 2 nM
MEK1, IC50: 2 nM
  Pan Inhibitor 99.44%
U0126-EtOH
MEK2, IC50: 60 nM
MEK1, IC50: 70 nM
  Pan Inhibitor 98.70%
PD98059
MEK2, IC50: 50 μM
MEK1, IC50: 2-7 μM
  Pan Inhibitor 99.94%
PD0325901
MEK2, Ki: 1 nM
MEK1, Ki: 1 nM
MEK, IC50: 0.33 nM
Pan Inhibitor 99.95%
PD0325901-O-C2-dioxolane
MEK2
MEK1
  Pan Inhibitor
Trametinib (DMSO solvate)
MEK2, IC50: 2 nM
MEK1, IC50: 2 nM
  Pan Inhibitor 99.77%
Refametinib
MEK2, IC50: 47 nM
MEK1, IC50: 19 nM
  Pan Inhibitor 99.82%
Pimasertib
MEK2
MEK1
  Pan Inhibitor 99.70%
SL327
MEK2, IC50: 220 nM
MEK1, IC50: 180 nM
  Pan Inhibitor >98.0%
RO4987655
MEK2, IC50: 5.2 nM
MEK1, IC50: 5.2 nM
  Pan Inhibitor 99.17%
AZD8330
MEK2, IC50: 7 nM
MEK1, IC50: 7 nM
  Pan Inhibitor 99.14%
BI-847325
MEK2, IC50: 4 nM
    Pan Inhibitor 99.14%
U0126
MEK2, IC50: 60 nM
MEK1, IC50: 70 nM
  Pan Inhibitor
Hypothemycin
MEK2, Ki: 38 nM
MEK1, Ki: 17 nM
  Pan Inhibitor