1. MAPK/ERK Pathway
  2. MEK
  3. PD318088

PD318088 

Cat. No.: HY-12062 Purity: 99.88%
Handling Instructions

PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088can be used for cancer research.

For research use only. We do not sell to patients.

PD318088 Chemical Structure

PD318088 Chemical Structure

CAS No. : 391210-00-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 201 In-stock
Estimated Time of Arrival: December 31
5 mg USD 163 In-stock
Estimated Time of Arrival: December 31
10 mg USD 307 In-stock
Estimated Time of Arrival: December 31
50 mg USD 931 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1260 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088can be used for cancer research[1].

IC50 & Target[1][2]

MEK

 

Molecular Weight

561.09

Formula

C₁₆H₁₃BrF₃IN₂O₄

CAS No.

391210-00-7

SMILES

BrC1=CC(C(NOCC(CO)O)=O)=C(C(F)=C1F)NC2=CC=C(C=C2F)I

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (178.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7822 mL 8.9112 mL 17.8225 mL
5 mM 0.3564 mL 1.7822 mL 3.5645 mL
10 mM 0.1782 mL 0.8911 mL 1.7822 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (4.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (4.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (4.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PD318088PD 318088PD-318088MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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PD318088
Cat. No.:
HY-12062
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