MEK Inhibitors

MEK1

MEK2

MEK5

MEK

MAP2K4/MEK4

MAP2K7/MEK7

MEK Inhibitors, Antagonists & Activators

Product Name	MEK1	MEK2	MEK5	MEK	MAP2K4/MEK4	MAP2K7/MEK7	Purity
Trametinib	MEK1, IC₅₀: 2 nM	MEK2, IC₅₀: 2 nM					99.93%
Mirdametinib	MEK1, Ki: 1 nM	MEK2, Ki: 1 nM		MEK, IC₅₀: 0.33 nM			99.95%
U0126	MEK1, IC₅₀: 70 nM	MEK2, IC₅₀: 60 nM					98.57%
PD98059	MEK1, IC₅₀: 2-7 μM	MEK2, IC₅₀: 50 μM					99.94%
Selumetinib	MEK1, IC₅₀: 14 nM			MEK, IC₅₀: 12 nM			99.72%
Cobimetinib	MEK1, IC₅₀: 4.2 nM						99.81%
C16-PAF				MEK			99.86%
Binimetinib				MEK, IC₅₀: 12 nM			99.92%
U0126-EtOH	MEK1, IC₅₀: 70 nM	MEK2, IC₅₀: 60 nM					99.41%
Isorhamnetin	MEK1						99.94%
Lidocaine				MEK			99.96%
Avutometinib				MEK, IC₅₀: 160 nM			99.43%
trans-Zeatin				MEK			99.77%
Trametinib (DMSO solvate)	MEK1, IC₅₀: 2 nM	MEK2, IC₅₀: 2 nM					99.50%
Lidocaine hydrochloride				MEK			99.84%
CI-1040	MEK1, IC₅₀: 17 nM						99.91%
Lixisenatide	MEK1	MEK2					99.93%
TERT activator-1	MEK1	MEK2					99.50%
BIX02189			MEK5, IC₅₀: 1.5 nM				99.72%
Tunlametinib	MEK1	MEK2					99.53%
Pimasertib	MEK1	MEK2					99.60%
GDC-0623	MEK1, Ki: 0.13 nM (+ATP)						98.74%
Trametiglue	MEK1	MEK2					98.81%
Refametinib	MEK1, IC₅₀: 19 nM	MEK2, IC₅₀: 47 nM					99.82%
Lidocaine (Standard)				MEK
RGB-286638	MEK1, IC₅₀: 54 nM						99.70%
Azelnidipine	MEK1	MEK2					99.79%
AZD8330	MEK1, IC₅₀: 7 nM	MEK2, IC₅₀: 7 nM					99.06%
TAK-733				MEK, IC₅₀: 3.2 nM			99.79%
APS-2-79	MEK1						99.38%
Lidocaine hydrochloride hydrate				MEK			99.80%
SL327	MEK1, IC₅₀: 180 nM	MEK2, IC₅₀: 220 nM					99.57%
MS432	MEK1, DC₅₀: 31 nM (in HT29 cells) MEK1, DC₅₀: 31 nM (in SK-MEL-28 cells)	MEK2, DC₅₀: 17 nM (in HT29 cells) MEK2, DC₅₀: 9.3 nM (in SK-MEL-28 cells)					99.72%
PD318088	MEK1	MEK2					99.82%
Cobimetinib hemifumarate	MEK1, IC₅₀: 4.2 nM						99.68%
RO4987655	MEK1, IC₅₀: 5.2 nM	MEK2, IC₅₀: 5.2 nM					99.01%
Zapnometinib				MEK, IC₅₀: 5.7 nM			99.85%
MAP855	MEK1, IC₅₀: 3 nM						98.48%
BI-847325		MEK2, IC₅₀: 4 nM					98.15%
GW284543			MEK5				99.94%
RGB-286638 free base	MEK1, IC₅₀: 54 nM						98.09%
Lixisenatide acetate	MEK1	MEK2					99.11%
Polfurmetinib				MEK			98.21%
BIX02188			MEK5, IC₅₀: 4.3 nM				99.85%
PD 198306				MEK			99.75%
PD184161				MEK, IC₅₀: 10-100 nM			98.08%
Cucurbitacin IIa	MEK1						99.90%
Nedometinib	MEK1, IC₅₀: 135 nM						98.09%
MEK inhibitor				MEK			98.35%
Hypothemycin	MEK1, Ki: 17 nM	MEK2, Ki: 38 nM					98.0%
Balamapimod				MEK			99.47%
PD-334581	MEK1						99.72%
CHMFL-EGFR-202	MEK1, IC₅₀: 161 nM						99.75%
Refametinib (R enantiomer)				MEK, EC₅₀: 2-15 nM
SHY-867				MEK
SHY-855				MEK
PD0325901-O-C2-dioxolane	MEK1	MEK2					98.62%
APS-2-79 hydrochloride	MEK1						98.42%
MEK-IN-7	MEK1, IC₅₀: 29.62 nM
GW284543 hydrochloride			MEK5
RO5068760	MEK1, IC₅₀: 0.025 μM
MEK/RAF-IN-1	MEK1, IC₅₀: 28 nM
MS910	MEK1	MEK2
MEK/PI3K-IN-2	MEK1, IC₅₀: 352 ± 2 nM
STK899704				MEK
MEK/PI3K-IN-1	MEK1, IC₅₀: 124 ± 11 nM
MEK-IN-10	MEK1, IC₅₀: 782 nM
(E/Z)-Chk2-IN-1	MEK1
MEK4 IN-4	MEK1, IC₅₀: 15 μM				MAP2K4/MEK4, IC₅₀: 0.041 μM	MAP2K7/MEK7, IC₅₀: 12 μM
Isorhamnetin (Standard)	MEK1
MEK1-IN-1	MEK1, : 10.29 nM
GIT1-IN-1	MEK1	MEK2
MEK4 IN-3					MAP2K4/MEK4, IC₅₀: 78 nM
NEPP11	MEK1	MEK2
ST-168	MEK1, IC₅₀: 182 nM
CI-1040 hydrochloride	MEK1
Polfurmetinib hydrate				MEK
G-963	MEK1, IC₅₀: 0.012 μM
Lixisenatide (Leu-¹³C₆,¹⁵N) TFA	MEK1
MEK-IN-1				MEK

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