1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor

Discoidin Domain Receptor

Discoidin domain receptors (DDRs) are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen. Several signaling molecules have been implicated in DDR signaling, including Shp-2, Src, and MAPK pathways. DDRs have been reported to induce the expression of various genes including matrix metalloproteinases and bone morphogenetic proteins, but the regulatory mechanisms underlying DDR-induced gene expression remain to be determined. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets.

Discoidin Domain Receptor Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-100388A
    SHP099 hydrochloride Inhibitor
    SHP099 (hydrochloride) is a selective and orally bioavailable small-molecule SHP2 inhibitor with IC50 of 0.071 (mu)M.
  • HY-100388
    SHP099 Inhibitor
    SHP099 is a selective and orally bioavailable small-molecule SHP2 inhibitor with IC50 of 0.071 (mu)M.
  • HY-13979
    DDR1-IN-1 Inhibitor
    DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).