1. Protein Tyrosine Kinase/RTK
  2. Discoidin Domain Receptor
  3. WRG-28

WRG-28 

Cat. No.: HY-114169
Handling Instructions

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2.

For research use only. We do not sell to patients.

WRG-28 Chemical Structure

WRG-28 Chemical Structure

CAS No. : 1913291-02-7

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Description

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

IC50 & Target

DDR2

230 nM (IC50)

Molecular Weight

410.44

Formula

C₂₁H₁₈N₂O₅S

CAS No.

1913291-02-7

SMILES

O=S(C1=CC=C(COC2=CC(OC3=CC(C=CC3=N4)=O)=C4C=C2)C=C1)(NCC)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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WRG-28
Cat. No.:
HY-114169
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