Signaling Pathway

5 alpha Reductase

5 alpha Reductase

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5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer. There are three isoenzymes of 5-alpha reductase, which vary in different tissues with age. 5α-reductases catalyze the following chemical reaction: a 3-oxo-5α-steroid + acceptor a 3-oxo-Δ4-steroid + reduced acceptor. The two substrates of 5α-reductases are a 3-oxo-5α-steroid and acceptor, whereas its two products are 3-oxo-Δ4-steroid and a reduced acceptor. The mechanism of 5α reductase inhibition is complex, but involves the binding of NADPH to the enzyme followed by the substrate. 5α-reductase inhibitor drugs are used in benign prostatic hyperplasia, prostate cancer, male pattern baldness, and hormone replacement therapy (male to female) for transgendered women.

5 alpha Reductase Inhibitors & Modulators (3)

Product Name Catalog No. Brief Description
Dutasteride

HY-13613

Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes.

Finasteride

HY-13635

Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM).

Finasteride acetate

HY-13635A

Finasteride (acetate) is an orally active testosterone 5-alpha-reductase inhibitor.