1. Metabolic Enzyme/Protease
  2. 5 alpha Reductase
  3. 12-O-Methylcarnosic acid

12-O-Methylcarnosic acid (Synonyms: 12-Methoxycarnosic acid)

Cat. No.: HY-N7510
Handling Instructions

12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity.

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12-O-Methylcarnosic acid Chemical Structure

12-O-Methylcarnosic acid Chemical Structure

CAS No. : 62201-71-2

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Description

12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2].

In Vitro

12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1].
12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL[2].

Molecular Weight

346.46

Formula

C₂₁H₃₀O₄

CAS No.

62201-71-2

SMILES

O=C([[email protected]]12CCCC(C)(C)[[email protected]]1([H])CCC3=C2C(O)=C(OC)C(C(C)C)=C3)O

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Keywords:

12-O-Methylcarnosic acid12-Methoxycarnosic acid5 alpha Reductase5α-reductaseInhibitorinhibitorinhibit

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