Androgen Receptor
The androgen receptor (AR) (NR3C4, nuclear receptor subfamily 3, group C, gene 4), a ligand-dependent nuclear transcription factor, belongs to the steroid hormone group of nuclear receptors with the estrogen receptor (ER), glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR). Like other members of the nuclear receptor family, the AR comprises three main functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD) and the ligand binding domain. The AR is cytoplasmic, associated with heat-shock and other chaperone proteins in the absence of ligand. The interaction of androgens and AR results in a conformational change, dissociation of chaperone proteins and exposure of the NLS (NLS). The androgen/AR complex translocates to the nucleus where it dimerises and binds to AREs within classical target genes to modulate gene transcription. The transcriptional regulatory effects of the AR include pathways involved in cell growth and proliferation, cell cycle progression, protein synthesis, and cell death.
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Androgen Receptor Recombinant Proteins (1)
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Inhibitors & Agonists (470)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
