1. Recombinant Proteins
  2. Receptor Proteins
  3. Nuclear Receptor Superfamily
  4. Androgen Receptor

The androgen receptor (AR) (NR3C4, nuclear receptor subfamily 3, group C, gene 4), a ligand-dependent nuclear transcription factor, belongs to the steroid hormone group of nuclear receptors with the estrogen receptor (ER), glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR). Like other members of the nuclear receptor family, the AR comprises three main functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD) and the ligand binding domain. The AR is cytoplasmic, associated with heat-shock and other chaperone proteins in the absence of ligand. The interaction of androgens and AR results in a conformational change, dissociation of chaperone proteins and exposure of the NLS (NLS). The androgen/AR complex translocates to the nucleus where it dimerises and binds to AREs within classical target genes to modulate gene transcription. The transcriptional regulatory effects of the AR include pathways involved in cell growth and proliferation, cell cycle progression, protein synthesis, and cell death.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72088
    Androgen receptor Protein, Human (His-SUMO)

    AIS; ANDR_HUMAN; Androgen nuclear receptor variant 2; Androgen receptor dihydrotestosterone receptor; testicular feminization; SBMA; SMAX1; Testicular Feminization TFM; TFM

    Human E. coli
    The androgen receptor protein is a steroid hormone receptor that acts as a ligand-activated transcription factor that regulates gene expression and affects cell proliferation and differentiation. Coactivators and corepressors such as ZBTB7A negatively regulate androgen receptor signaling by recruiting NCOR1 and NCOR2 to androgen response elements on target genes. Androgen receptor Protein, Human (His-SUMO) is the recombinant human-derived Androgen receptor protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag. The total length of Androgen receptor Protein, Human (His-SUMO) is 369 a.a., with molecular weight of ~62.4 kDa.
Cat. No. Product Name Effect Purity