1. Recombinant Proteins
  2. Enzymes & Regulators
  3. ADAMs/ADAMTSs

ADAM (A Disintegrin and Metallo-proteinases) and ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs), which together are known as adamalysins, are the matrix zinc-dependent metalloproteinases. ADAM metalloproteinases are transmembrane and secreted proteins while ADAMTS are secretion forms. Adamalysins are mainly localized in the extracellular matrix (ECM), with which they can be linked by spacer domain (SD) or thrombospondin motif (TS). All adamalysins are initially synthesized as precursors, and most of them can be activated by furin. They play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The ADAMs belongs to the metzincin superfamily. ADAMs consists of a prodomain, a metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. ADAMs have essential functions in cell-cell interactions (such as adhesion and fusion), in signaling, and in proteolysis (also termed ectodomain shedding) of important cytokines, cytokine receptors, and other targets. Thus, ADAMs are fundamental to many control processes in development and homeostasis, and they are also linked to pathological states when their functions are dysregulated, including cancer, cardiovascular disease, asthma, Alzheimer’s disease. ADAMTSs (TS=thrombospondin motifs) is a related family of ADAMs that also belong to the metzincin protease superfamily. ADAMTS have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72814
    ADAM12 Protein, Human (HEK293, His)

    Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha; ADAM12; MLTN

    Human HEK293
    ADAM12 Protein significantly contributes to skeletal muscle regeneration, particularly in initiating cell fusion. Its multifaceted involvement extends to forming macrophage-derived giant cells (MGC) and differentiating osteoclasts from mononuclear precursors, showcasing a broader role beyond muscle regeneration. ADAM12 Protein, Human (HEK293, His) is the recombinant human-derived ADAM12 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM12 Protein, Human (HEK293, His) is 485 a.a., with molecular weight of 27 & 55 & 72 kDa, respectively.
  • HY-P72815
    ADAM17/TACE Protein, Rat (HEK293, His)

    Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; CD156b; Tace

    Rat HEK293
    ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ADAM17/TACE Protein, Rat (HEK293, His) is 546 a.a., with molecular weight of 57 & 20 kDa, respectively.
  • HY-P7460
    ADAMDEC1 Protein, Human (HEK293, His)

    rHuADAM-like protein decysin-1, His; ADAMDEC-1; ADAM-like protein decysin-1

    Human HEK293
    ADAMDEC1 Protein, Human (HEK293, His) is human recombinant ADAM-like protein decysin-1 (ADAMDEC1) with a 6His tag at the C-terminus. ADAMDEC1 Protein, Human (HEK293, His) is produced by mammalian expression system in human cells and the target gene encoding Ile31-Glu470 is expressed.
  • HY-P75532
    ADAM8 Protein, Human (HEK293, His)

    ADAM 8; ADAM metallopeptidase domain 8; CD156a; MS2

    Human HEK293
    ADAM8 protein is suggested to be involved in leukocyte extravasation, indicating its potential role in facilitating the migration of white blood cells from blood vessels into surrounding tissues. This implies ADAM8's contribution to immune responses by regulating leukocyte movement across the endothelial barrier, a crucial step in inflammatory and immune surveillance processes. ADAM8 Protein, Human (HEK293, His) is the recombinant human-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Human (HEK293, His) is 639 a.a., with molecular weight of ~71 kDa.
  • HY-P75564
    ADAM15 Protein, Mouse (HEK293, His)

    Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; MDC-15; Metargidin

    Mouse HEK293
    ADAM15 is an active metalloprotease that plays a crucial role in physiological processes and has gelatin-solubilizing and collagen-solubilizing activities. Notably, it affects wound healing, mediates intraepithelial cell/T cell interactions, and inhibits β-1 integrin-mediated cell adhesion and migration in airway smooth muscle cells. ADAM15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM15 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM15 Protein, Mouse (HEK293, His) is 680 a.a., with molecular weight of 75-110 kDa.
  • HY-P76135
    ADAMTSL1/Punctin Protein, Human (sf9, His)

    ADAMTS-like protein 1; ADAMTSL-1; Punctin-1; ADAMTSR1; C9orf94

    Human Sf9 insect cells
    ADAMTSL1/Punctin Protein, a member of the ADAMTS family, encodes a unique secreted protein lacking metalloproteinase and disintegrin-like domains but retaining other ADAMTS domains, including the thrombospondin type 1 motif. Likely involved in crucial extracellular matrix functions, alternative splicing generates multiple transcript variants, each encoding distinct proteins. ADAMTSL1/Punctin Protein, Human (sf9, His) is the recombinant human-derived ADAMTSL1/Punctin protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of ADAMTSL1/Punctin Protein, Human (sf9, His) is 439 a.a., with molecular weight of ~48 KDa.
  • HY-P77293
    ADAM8 Protein, Rhesus Macaque (HEK293, His)

    ADAM 8; ADAM metallopeptidase domain 8; CD156a; MS2

    Rhesus Macaque HEK293
    ADAM8 is a transmembrane glycoprotein containing metalloproteinase and disintegrin domains, belonging to the ADAMs family. It has proteolytic, cell adhesion, cell fusion, and cell signaling properties. It is involved in ectodomain shedding of membrane proteins and is associated with inflammation and neurodegeneration. ADAM8 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Rhesus Macaque (HEK293, His) is 477 a.a., with molecular weight of ~53.4 KDa.
  • HY-P77558
    ADAM8 Protein, Mouse (HEK293, His)

    ADAM 8; Ms2; Adam8; CD156a; MGC134985

    Mouse HEK293
    ADAM8 protein potentially participates in leukocyte extravasation. ADAM8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Mouse (HEK293, His) is 642 a.a., with molecular weight (glycosylation form) of 60-72 & 35-45 kDa (Tris-Bis PAGE), respectively.
  • HY-P72061
    ADAM12 Protein, Mouse (Baculovirus, His-Myc)

    Adam12; MltnaDisintegrin and metalloproteinase domain-containing protein 12; ADAM 12; EC 3.4.24.-; Meltrin-alpha

    Mouse Sf9 insect cells
    ADAM12 Protein, Mouse (Baculovirus, His-Myc) is a disintegrin and a metalloprotease. ADAM12 is upregulated in epithelial cancers and contributes to increased tumor proliferation, metastasis, and endocrine resistance.
  • HY-P75533
    ADAM15 Protein, Human (HEK293, His)

    Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; MDC-15; Metargidin

    Human HEK293
    ADAM15 protein is an active metalloproteinase involved in wound healing, cell interactions, and T-cell aggregation. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. It suppresses cell motility towards fibronectin and cleaves E-cadherin. ADAM15 plays a role in glomerular cell migration, neovascularization, and cartilage remodeling. During sperm maturation, it may undergo proteolytic processing and potentially be involved in sperm-egg binding. ADAM15 Protein, Human (HEK293, His) is the recombinant human-derived ADAM15 protein, expressed by HEK293, with C-His labeled tag. The total length of ADAM15 Protein, Human (HEK293, His) is 490 a.a., with molecular weight of 65-70 kDa.
  • HY-P75534
    ADAM15 Protein, Human (CHO, His)

    Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; MDC-15; Metargidin

    Human CHO
    ADAM15 protein is an active metalloproteinase involved in wound healing, cell interactions, and T-cell aggregation. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. It suppresses cell motility towards fibronectin and cleaves E-cadherin. ADAM15 plays a role in glomerular cell migration, neovascularization, and cartilage remodeling. During sperm maturation, it may undergo proteolytic processing and potentially be involved in sperm-egg binding. ADAM15 Protein, Human (CHO, His) is the recombinant human-derived ADAM15 protein, expressed by CHO, with C-His labeled tag. The total length of ADAM15 Protein, Human (CHO, His) is 490 a.a., with molecular weight of 65-70 kDa.
  • HY-P77867
    ADAM9 Protein, Human (HEK293, His)

    ADAM 9; Meltrin-gamma; Mdc9; Mltng; Adam9; Kiaa0021; AU020942; MDC9; mKIAA0021; CORD9; MCMP; MLTNG

    Human HEK293
    ADAM9, a metalloprotease, cleaves and releases TEK, VEGFR2/KDR/Flk-1, EPHB4, CD40, VCAM1, and CDH5, playing a pivotal role in tumorigenesis and angiogenesis. It regulates cell motility through integrin interactions, mediates cell-cell and cell-matrix interactions, and may act as an alpha-secretase for APP, suggesting involvement in neurobiology and neurodegenerative disorders. ADAM9 Protein, Human (HEK293, His) is the recombinant human-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM9 Protein, Human (HEK293, His) is 669 a.a., with molecular weight of 40-45 kDa.
  • HY-P75531
    ADAM9 Protein, Mouse (HEK293, His)

    Disintegrin and metalloproteinase domain-containing protein 9; Meltrin-gamma; ADAM 9

    Mouse HEK293
    ADAM9 protein is a metalloprotease that plays an important role in tumorigenesis and angiogenesis. It cleaves TEK, VEGFR2/KDR/Flk-1, EPHB4, CD40, VCAM1 and CDH5, regulating cancer-related signaling pathways and blood vessel formation. ADAM9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag.
Cat. No. Product Name Effect Purity