ADAM17/TACE
ADAM17, widely known as TACE (TNF-alpha converting enzyme), is the prototype inducible sheddase and arguably the most intensively studied family member. It releases tumor necrosis factor-alpha and its receptors, the EGFR ligands TGF-alpha, amphiregulin and HB-EGF, plus IL-6 receptor and L-selectin. Germline loss in mice phenocopies EGFR deficiency, confirming ADAM17 as the main source of EGFR ligands during development. Its trafficking and activation are controlled by the regulatory pseudoproteases iRhom1 and iRhom2, and potent selective inhibitors continue to be pursued for inflammatory and autoimmune indications. Its rapid mobilization after inflammatory stimuli makes ADAM17 the major source of circulating TNF-alpha in acute responses, complementing its constitutive developmental functions.
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ADAM17/TACE Recombinant Proteins (3)
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Inhibitors & Agonists (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
