4-1BB
4-1BB (TNFRSF9, CD137, ILA) is an inducible co-stimulatory receptor of the TNF receptor superfamily, expressed on activated CD4+ and CD8+ T cells, regulatory T cells, NK cells, NKT cells, dendritic cells, monocytes and neutrophils. 4-1BB is a type I transmembrane glycoprotein with four cysteine-rich extracellular domains; ligand binding (4-1BBL, TNFSF9) recruits TRAF1/2 to activate canonical NF-κB, MAPK and ERK pathways, enhancing CD8+ T-cell proliferation, survival (via BCL-xL and BFL-1), mitochondrial biogenesis and cytotoxicity, and augmenting NK-cell function and antibody-dependent cellular cytotoxicity. Unlike CD28, 4-1BB signals are dispensable for initial activation but decisive for sustaining effector responses and generating durable CD8+ T-cell memory, especially under chronic antigen and hypoxic tumor conditions. Agonistic anti-4-1BB antibodies (urelumab, utomilumab) are in clinical development for solid tumors and lymphomas, particularly in combination with CAR-T cells and immune checkpoint blockade; hepatic toxicity of strong agonism necessitates carefully engineered formats.
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4-1BB Protéines Recombinantes (27)
4-1BB/TNFRSF9 Protein, Human (HEK293, Fc-Avi)
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Cat. No.: HY-P78386
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P70681
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Human (HEK293, His)
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Cat. No.: HY-P70678
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P72884
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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CD137/4-1BB Protein, Canine (HEK293, His)
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Cat. No.: HY-P75610
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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CD137/4-1BB Protein, Rhesus Macaque (HEK293, His)
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Cat. No.: HY-P76199
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Mouse (HEK293, C-hFc)
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Cat. No.: HY-P7447A
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Mouse (HEK293, Fc, solution)
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Cat. No.: HY-P7447
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Human (CHO, Fc)
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Cat. No.: HY-P7317
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78067
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, Fc-Avi)
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Cat. No.: HY-P78068
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Human
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Cat. No.: HY-P7125
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Rabbit (HEK293, His)
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Cat. No.: HY-P78599
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Mouse (Biotinylated, isoform 2, HEK293, His-Avi)
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Cat. No.: HY-P78794
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, Fc)
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Cat. No.: HY-P74335
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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CD137/4-1BB Protein, Canine (HEK293, Fc)
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Cat. No.: HY-P75609
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)
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Cat. No.: HY-P76200
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Mouse (isoform 2, HEK293, His)
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Cat. No.: HY-P77574
Pureté: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1BB Homolog; T Cell Antigen ILA; 4-1BB Ligand Receptor; T-Cell Antigen ILA; CD137 Antigen; IMD109; TNF Receptor Superfamily Member 9; Interleukin-Activated Receptor, Homolog Of Mouse Ly63
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CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc)
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Cat. No.: HY-P7810
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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4-1BB/TNFRSF9 Protein, Rat (HEK293, His)
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Cat. No.: HY-P78614
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF9; CDw137; Prev. ILA; Tumor Necrosis Factor Receptor Superfamily, Member 9; CD137; Induced By Lymphocyte Activation (ILA); 4-1BB; Homolog Of Mouse 4-1BB; Tumor Necrosis Factor Receptor Superfamily Member 9; Receptor Protein 4-1BB; T-Cell Antigen 4-1
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
