CAMKK
CaMKK1 (alpha) and CaMKK2 (beta) are the calcium/calmodulin-dependent kinase kinases positioned above the AMPK/CaMKI branch. On binding calcium-loaded calmodulin they phosphorylate a single threonine in the activation loops of AMPK, CaMKI and CaMKIV, coupling cytosolic calcium transients to energy sensing, transcription and metabolism. CaMKK2 is nuclear-enriched and prominent in brain, hematopoietic cells and prostate tissue, where it has been proposed to support androgen-independent growth; CaMKK1 is more broadly distributed and contributes to AMPK activation in lymphocytes. The pan-inhibitor STO-609 remains the standard tool compound, and selective CaMKK2 inhibitors are being developed for metabolic disease and oncology.
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CAMKK Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
