CAMKK1 Protein, Human (Inactive, sf9, His)
The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (sf9, His) is the recombinant human-derived CAMKK1 protein, expressed by sf9 insect cells , with N-6*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (sf9, His) is the recombinant human-derived CAMKK1 protein, expressed by sf9 insect cells , with N-6*His labeled tag.
Background
CAMKK1, a calcium/calmodulin-dependent protein kinase, plays a pivotal role in a proposed calcium-triggered signaling cascade that impacts various cellular processes. This kinase exhibits the ability to phosphorylate CAMK1, CAMK1D, CAMK1G, and CAMK4, suggesting its involvement in regulating multiple downstream effectors. CAMKK1 is particularly implicated in the modulation of cell apoptosis, where it promotes cell survival by phosphorylating AKT1/PKB. This phosphorylation event, in turn, inhibits the pro-apoptotic protein BAD (Bcl2-antagonist of cell death), highlighting the intricate regulatory role of CAMKK1 in cellular survival pathways.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-6*His
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Accession
Q8N5S9 (M1-S505)
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Gene ID84254
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Molecular Construction
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N-term
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6*His
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CAMKK1 (M1-S505)
Accession # Q8N5S9 -
C-term
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Protein Length
Full Length
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Synonyms
CAMKK1; DKFZp761M0423; Calcium/Calmodulin Dependent Protein Kinase Kinase 1; CaM-KK Alpha; CAMKKA; MGC34095; Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha; CaM-KK 1; Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha; CaMKK 1; Calcium/
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AA Sequence
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLVKEGFGEGGKSPELPGVQEDEAAS
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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