CAMKK1 Protein, Human (Sf9, His)

The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (Sf9, His) is the recombinant human-derived CAMKK1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of CAMKK1 Protein, Human (Sf9, His) is 505 a.a., .

CAMKK1, a calcium/calmodulin-dependent protein kinase, plays a pivotal role in a proposed calcium-triggered signaling cascade that impacts various cellular processes. This kinase exhibits the ability to phosphorylate CAMK1, CAMK1D, CAMK1G, and CAMK4, suggesting its involvement in regulating multiple downstream effectors. CAMKK1 is particularly implicated in the modulation of cell apoptosis, where it promotes cell survival by phosphorylating AKT1/PKB. This phosphorylation event, in turn, inhibits the pro-apoptotic protein BAD (Bcl2-antagonist of cell death), highlighting the intricate regulatory role of CAMKK1 in cellular survival pathways.

Human

Sf9 insect cells

N-6*His

Q8N5S9 (M1-S505)

84254

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.