2. Oligonucleotides
  3. Cationic Lipids

Cationic Lipids

The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.

Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.

Cationic Lipids (96):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112251
    D-Lin-MC3-DMA 1224606-06-7 99.66%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
    D-Lin-MC3-DMA
  • HY-138170
    ALC-0315 2036272-55-4 99.81%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
    ALC-0315
  • HY-134541
    SM-102 2089251-47-6 ≥98.0%
    SM-102 is an ionizable amino lipid that can be used for the formation of lipid nanoparticles (LNPs). SM-102 has the potential for development of lipid nanoparticles for delivery of mRNA-based vaccines.
    SM-102
  • HY-112754A
    DOTAP chloride 132172-61-3 ≥98.0%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
    DOTAP chloride
  • HY-112758
    DLin-KC2-DMA 1190197-97-7 ≥98.0%
    DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
    DLin-KC2-DMA
  • HY-W590532
    306-O12B 2566523-06-4 ≥98.0%
    306-O12B is an ionizable cationic lipid used for the generation of lipid nanoparticles (LNPs).
    306-O12B
  • HY-150115
    Lipid 10 2430034-02-7 ≥98.0%
    Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
    Lipid 10
  • HY-148488
    A18-Iso5-2DC18 2412492-09-0
    A18-Iso5-2DC18 (compound A18) is a lipidoid that can facilitate mRNA protein expression and induce a strong immune response mediated.
    A18-Iso5-2DC18
  • HY-145405
    C12-200 1220890-25-4 ≥98.0%
    C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids. C12-200 is commonly used for mRNA delivery.
    C12-200
  • HY-112757
    DLinDMA 871258-12-7 98.12%
    DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
    DLinDMA
  • HY-130751
    DODAP 127512-29-2 ≥98.0%
    DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on.
    DODAP
  • HY-139200
    DOTMA 104872-42-6 ≥98.0%
    DOTMA, as a tetra-methylated DOTA analogue, is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.
    DOTMA
  • HY-145799
    5A2-SC8 1857341-90-2 ≥98.0%
    5A2-SC8 is a degradable lipid-like compound (ester-based dendrimer) for small RNAs delivery.
    5A2-SC8
  • HY-138171
    Lipid 5 2089251-33-0 98.08%
    Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
    Lipid 5
  • HY-134781
    CKK-E12 1432494-65-9 ≥98.0%
    CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. cKK-E12 was highly selective toward liver parenchymal cell in vivo,
    CKK-E12
  • HY-112755
    DODMA 104162-47-2 ≥98.0%
    DODMA, a cationic lipid, is used for the preparation of liposomes.
    DODMA
  • HY-46759
    Genevant CL1 1450888-71-7 ≥98.0%
    Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery[1][2].
    Genevant CL1
  • HY-145793
    FTT5 2328129-27-5 ≥98.0%
    FTT5 is a lipid-like compound for efficient delivery of long mRNAs in vivo.
    FTT5
  • HY-151507
    306Oi10 2322290-93-5 ≥98.0%
    306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA.
    306Oi10
  • HY-148855
    OF-C4-Deg-Lin 2383003-60-7
    OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.
    OF-C4-Deg-Lin