1. Oligonucleotides
  2. Cationic Lipids

Cationic Lipids

The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.

Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.

Cationic Lipids (23):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112251
    D-Lin-MC3-DMA 1224606-06-7 ≥98.0%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
    D-Lin-MC3-DMA
  • HY-138170
    ALC-0315 2036272-55-4 ≥98.0%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
    ALC-0315
  • HY-112754A
    DOTAP chloride 132172-61-3 ≥98.0%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
    DOTAP chloride
  • HY-112758
    DLin-KC2-DMA 1190197-97-7 ≥98.0%
    DLin-KC2-DMA is a cationic/ionizable lipid for siRNA delivery.
    DLin-KC2-DMA
  • HY-134541
    SM-102 2089251-47-6 ≥98.0%
    SM-102 is an ionizable amino lipid that can be used for the formation of lipid nanoparticles (LNPs). SM-102 has the potential for development of lipid nanoparticles for delivery of mRNA-based vaccines.
    SM-102
  • HY-145405
    C12-200 1220890-25-4 ≥98.0%
    C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids. C12-200 is commonly used for mRNA delivery.
    C12-200
  • HY-145795
    OF-02 1883431-67-1
    OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.
    OF-02
  • HY-134781
    CKK-E12 1432494-65-9
    CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 was highly selective toward liver parenchymal cell in vivo,
    CKK-E12
  • HY-112757
    DLinDMA 871258-12-7 98.12%
    DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
    DLinDMA
  • HY-139200
    DOTMA 104872-42-6 ≥98.0%
    DOTMA, as a tetra-methylated DOTA analogue, is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.
    DOTMA
  • HY-130751
    DODAP 127512-29-2 ≥98.0%
    DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on.
    DODAP
  • HY-139298
    L319 1351586-50-9 ≥98.0%
    L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1.
    L319
  • HY-143702
    Fluorescent DOTAP 1010076-97-7
    Fluorescent DOTAP, a cationic lipid, can be used for the research of nucleic acid and protein delivery.
    Fluorescent DOTAP
  • HY-W440684
    C13-113-tetra-tail 1381861-97-7
    C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
    C13-113-tetra-tail
  • HY-145797
    L343 1443520-22-6
    L343 is an ionizable cationic lipidoid and can be used to synthetic liposomes for systemic delivery of RNAi therapeutics.
    L343
  • HY-W440683
    C13-112-tetra-tail 1381861-92-2
    C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).
    C13-112-tetra-tail
  • HY-144014
    MVL5 464926-03-2
    MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA.
    MVL5
  • HY-145794
    ZA3-Ep10 2090299-48-0
    ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery and non-viral CRISPR/Cas gene editing.
    ZA3-Ep10
  • HY-143210
    Transfectam 124050-77-7
    Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells.
    Transfectam
  • HY-133952
    7-Oxotridecanedioic acid 101171-43-1
    7-Oxotridecanedioic acid is a biodegradable cationic lipid intermediate compound for lipid nanoparticles formation. 7-Oxotridecanedioic acid can be incorporated into a lipid particle for delivering active agents.
    7-Oxotridecanedioic acid