2. Oligonucleotides
  3. Cationic Lipids

Cationic Lipids

The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.

Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.

Cationic Lipids (138):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112251
    D-Lin-MC3-DMA 1224606-06-7 99.70%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
    D-Lin-MC3-DMA
  • HY-138170
    ALC-0315 2036272-55-4 99.81%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
    ALC-0315
  • HY-134541
    SM-102 2089251-47-6 ≥98.0%
    SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
    SM-102
  • HY-112754A
    DOTAP chloride 132172-61-3 ≥98.0%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
    DOTAP chloride
  • HY-145405
    C12-200 1220890-25-4 ≥98.0%
    C12-200 is an ionizable cationic lipid and auxiliary lipid. C12-200 is commonly used for mRNA delivery. Administration of human erythropoietin (EPO) mRNA or factor VII siRNA increased and decreased serum factor VII levels, respectively, in LNPs mice containing C12-200.
    C12-200
  • HY-156448
    80-O14B 1624618-01-4 99.56%
    80-O14B is an cationic lipid-like compound for CRISPR/Cas9 delivery.
    80-O14B
  • HY-W590549
    Dioleyldimethylammonium chloride 7212-69-3
    Dioleyldimethylammonium chloride (DODAC) is a cationic lipid that can be used as transfection reagent.
    Dioleyldimethylammonium chloride
  • HY-139305
    CL4H6 2256087-35-9
    CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response.
    CL4H6
  • HY-112758
    DLin-KC2-DMA 1190197-97-7 ≥98.0%
    DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
    DLin-KC2-DMA
  • HY-145799
    5A2-SC8 1857341-90-2 99.19%
    5A2-SC8 is a degradable lipid-like compound (ester-based dendrimer) for small RNAs delivery.
    5A2-SC8
  • HY-139200
    DOTMA 104872-42-6 ≥98.0%
    DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo.
    DOTMA
  • HY-130751
    DODAP 127512-29-2 ≥98.0%
    DODAP is a cationic lipid. The ionizable lipid DODAP is the lipid component of liposomes (pKa = 5.59 in TNS binding tests). DODAP can be used for siRNA encapsulation and in vitro and in vivo delivery of immunostimulated chemotherapeutic active molecules.
    DODAP
  • HY-112757
    DLinDMA 871258-12-7 98.12%
    DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery.
    DLinDMA
  • HY-134781
    CKK-E12 1432494-65-9 ≥98.0%
    CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
    CKK-E12
  • HY-138171
    Lipid 5 2089251-33-0 99.28%
    Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
    Lipid 5
  • HY-46760
    CCD Lipid01 1799316-64-5 99.69%
    CCD Lipid01 is a cationic lipid useful in the delivery of biologically active agents to cells and tissues (extracted from patent WO2015095340 A1).
    CCD Lipid01
  • HY-151507
    306Oi10 2322290-93-5 ≥98.0%
    306Oi10 is a branched-chain ionizable lipidoid that can be used for constructing lipid nanoparticles (LNPs) for the delivery of messenger RNA.
    306Oi10
  • HY-46759
    Genevant CL1 1450888-71-7 ≥98.0%
    Genevant CL1 is an ionizable lipid (lipid 10, pKa=6.3), and it can be used for mRNA lipid nanoparticle (LNP) vaccine delivery[1][2].
    Genevant CL1
  • HY-112755
    DODMA 104162-47-2 ≥98.0%
    DODMA, a cationic lipid, is used for the preparation of liposomes.
    DODMA
  • HY-152229
    G0-C14 1510653-27-6 ≥98.0%
    G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for agent and vaccine delivery.
    G0-C14