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D-Lin-MC3-DMA 

Cat. No.: HY-112251 Purity: >99.0%
Handling Instructions

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

For research use only. We do not sell to patients.

D-Lin-MC3-DMA Chemical Structure

D-Lin-MC3-DMA Chemical Structure

CAS No. : 1224606-06-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 254 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
25 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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  • References

Description

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

In Vivo

Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1].

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 43.33 mg/mL (67.48 mM)

Ethanol : 16.67 mg/mL (25.96 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5574 mL 7.7871 mL 15.5741 mL
5 mM 0.3115 mL 1.5574 mL 3.1148 mL
10 mM 0.1557 mL 0.7787 mL 1.5574 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

642.09

Formula

C₄₃H₇₉NO₂

CAS No.

1224606-06-7

SMILES

O=C(OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
D-Lin-MC3-DMA
Cat. No.:
HY-112251
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D-Lin-MC3-DMA

Cat. No.: HY-112251